JPS5576899A - 24,24-difluoro-25-hydroxycholestene derivative or its hydroxy-protected derivative and its preparation - Google Patents

24,24-difluoro-25-hydroxycholestene derivative or its hydroxy-protected derivative and its preparation

Info

Publication number
JPS5576899A
JPS5576899A JP14902878A JP14902878A JPS5576899A JP S5576899 A JPS5576899 A JP S5576899A JP 14902878 A JP14902878 A JP 14902878A JP 14902878 A JP14902878 A JP 14902878A JP S5576899 A JPS5576899 A JP S5576899A
Authority
JP
Japan
Prior art keywords
difluoro
derivative
hydroxy
preparation
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14902878A
Other languages
Japanese (ja)
Other versions
JPS6244558B2 (en
Inventor
Yoshiro Kobayashi
Takeo Taguchi
Nobuo Ikegawa
Toru Takeshita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP14902878A priority Critical patent/JPS5576899A/en
Publication of JPS5576899A publication Critical patent/JPS5576899A/en
Publication of JPS6244558B2 publication Critical patent/JPS6244558B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

NEW MATERIAL:24,24-Difluoro-25-hydroxycholestenes of formula I (R1, R2 are H or hydroxyl-protecting groups; the dotted line represents single or double bond) or their hydroxyl-protected derivatives.
EXAMPLE: 3β-Acetoxy-24,24-difluorocholest-5-ene-25-ol.
USE: Synthetic intermediates of 24,24-difluoro-25-hydroxy vitamin D3 that is expected to show the same pharmaceutical activity as that of compounds of vitamin D3 series.
PREPARATION: 3β-Hydroxy-24,24-difluoro-27-norcholestene-25-on of formula II or its hydroxyl-protected derivative is made to react with methylmagnesium halide in an aprotonic inert solvent by a conventional method to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP14902878A 1978-12-04 1978-12-04 24,24-difluoro-25-hydroxycholestene derivative or its hydroxy-protected derivative and its preparation Granted JPS5576899A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14902878A JPS5576899A (en) 1978-12-04 1978-12-04 24,24-difluoro-25-hydroxycholestene derivative or its hydroxy-protected derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14902878A JPS5576899A (en) 1978-12-04 1978-12-04 24,24-difluoro-25-hydroxycholestene derivative or its hydroxy-protected derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5576899A true JPS5576899A (en) 1980-06-10
JPS6244558B2 JPS6244558B2 (en) 1987-09-21

Family

ID=15466084

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14902878A Granted JPS5576899A (en) 1978-12-04 1978-12-04 24,24-difluoro-25-hydroxycholestene derivative or its hydroxy-protected derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5576899A (en)

Also Published As

Publication number Publication date
JPS6244558B2 (en) 1987-09-21

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