JPS6445392A - Production of estradiol derivative - Google Patents

Production of estradiol derivative

Info

Publication number
JPS6445392A
JPS6445392A JP62202762A JP20276287A JPS6445392A JP S6445392 A JPS6445392 A JP S6445392A JP 62202762 A JP62202762 A JP 62202762A JP 20276287 A JP20276287 A JP 20276287A JP S6445392 A JPS6445392 A JP S6445392A
Authority
JP
Japan
Prior art keywords
estradiol
hydroxy
expressed
derivative
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62202762A
Other languages
Japanese (ja)
Inventor
Shigeo Fujii
Hidemi Suzuki
Kazuo Sato
Keizaburo Miki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tonen General Sekiyu KK
Original Assignee
Toa Nenryo Kogyyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toa Nenryo Kogyyo KK filed Critical Toa Nenryo Kogyyo KK
Priority to JP62202762A priority Critical patent/JPS6445392A/en
Publication of JPS6445392A publication Critical patent/JPS6445392A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Steroid Compounds (AREA)

Abstract

PURPOSE:To obtain the titled compound useful as a contraceptive agent in high yield, by reacting a hydroxy-estradiol derivative with a benzoic acid derivative in the presence of a triarylphosphine. CONSTITUTION:A 6-hydroxy-17beta-estradiol derivative (e.g. 6-hydroxy-estradiol THP in which the 3,17-positions are protected with tetrahydropyranyl groups) expressed by formula I (R<1> is protecting group) is reacted with a benzoic acid derivative expressed by formula II (X Is OH or halogen; R<2> is lower acyl; n is >=1) in the presence of a triarylphosphine (e.g. triphenylphosphine) to afford the aimed compound expressed by formula III (R<1> is H or OH-protecting group).
JP62202762A 1987-08-13 1987-08-13 Production of estradiol derivative Pending JPS6445392A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62202762A JPS6445392A (en) 1987-08-13 1987-08-13 Production of estradiol derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62202762A JPS6445392A (en) 1987-08-13 1987-08-13 Production of estradiol derivative

Publications (1)

Publication Number Publication Date
JPS6445392A true JPS6445392A (en) 1989-02-17

Family

ID=16462747

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62202762A Pending JPS6445392A (en) 1987-08-13 1987-08-13 Production of estradiol derivative

Country Status (1)

Country Link
JP (1) JPS6445392A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0573977A2 (en) * 1992-06-11 1993-12-15 Kureha Chemical Industry Co., Ltd. Novel estradiol derivative-chlorambucil conjugate, process for preparing the same, and pharmaceutical composition
KR100368103B1 (en) * 1998-05-28 2004-05-20 주식회사 태평양 Estrogen derivatives and their salts, and compositions having an ability for accelerating growth of hair containing the same

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0573977A2 (en) * 1992-06-11 1993-12-15 Kureha Chemical Industry Co., Ltd. Novel estradiol derivative-chlorambucil conjugate, process for preparing the same, and pharmaceutical composition
EP0573977A3 (en) * 1992-06-11 1996-01-31 Kureha Chemical Ind Co Ltd Novel estradiol derivative-chlorambucil conjugate, process for preparing the same, and pharmaceutical composition
KR100368103B1 (en) * 1998-05-28 2004-05-20 주식회사 태평양 Estrogen derivatives and their salts, and compositions having an ability for accelerating growth of hair containing the same

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