JPS5731685A - Preparation of 2',3',5'-triacetoxy-5-fluorouridine - Google Patents
Preparation of 2',3',5'-triacetoxy-5-fluorouridineInfo
- Publication number
- JPS5731685A JPS5731685A JP10545780A JP10545780A JPS5731685A JP S5731685 A JPS5731685 A JP S5731685A JP 10545780 A JP10545780 A JP 10545780A JP 10545780 A JP10545780 A JP 10545780A JP S5731685 A JPS5731685 A JP S5731685A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouridine
- triacetoxy
- expressed
- formula
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the titled compound which is a carcinostatic agent in high yield in one stage by reacting the 5,6-dihydro derivative of a 5-fluorouridiane with acetic anhydride.
CONSTITUTION: One mole 5,6-dihydro derivative of a 5-fluorouridine expressed by formula I (R is hydrogen, acyl, alkyl, halogenated acyl or halogenated alkyl) is reacted 3 moles or more acetic anhydride, if necessary in the presence of an acid acceptor, e.g. a trialkylamine or pyridine, at 120°C or below to give 2',3',5'-triacetoxy- 5-fluorouridine expressed by formula II.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10545780A JPS5731685A (en) | 1980-07-30 | 1980-07-30 | Preparation of 2',3',5'-triacetoxy-5-fluorouridine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10545780A JPS5731685A (en) | 1980-07-30 | 1980-07-30 | Preparation of 2',3',5'-triacetoxy-5-fluorouridine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5731685A true JPS5731685A (en) | 1982-02-20 |
Family
ID=14408107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10545780A Pending JPS5731685A (en) | 1980-07-30 | 1980-07-30 | Preparation of 2',3',5'-triacetoxy-5-fluorouridine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5731685A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2630447A1 (en) * | 1988-04-21 | 1989-10-27 | Central Glass Co Ltd | PROCESS FOR PREPARING DIACYCLE DERIVATIVES OF 2 (PRIME) -DESOXY-5-FLUOROURIDINE VIA A NEW INTERMEDIATE COMPOUND |
-
1980
- 1980-07-30 JP JP10545780A patent/JPS5731685A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2630447A1 (en) * | 1988-04-21 | 1989-10-27 | Central Glass Co Ltd | PROCESS FOR PREPARING DIACYCLE DERIVATIVES OF 2 (PRIME) -DESOXY-5-FLUOROURIDINE VIA A NEW INTERMEDIATE COMPOUND |
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