JPS55108857A - Preparation of 5-fluorouracil derivative - Google Patents
Preparation of 5-fluorouracil derivativeInfo
- Publication number
- JPS55108857A JPS55108857A JP1500979A JP1500979A JPS55108857A JP S55108857 A JPS55108857 A JP S55108857A JP 1500979 A JP1500979 A JP 1500979A JP 1500979 A JP1500979 A JP 1500979A JP S55108857 A JPS55108857 A JP S55108857A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouracil
- derivative
- fluorouracil derivative
- toluyl
- acyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title compound useful as an antitumor agent in high yield industrially advantageously, by reacting 5-fluorouracil with an aromatic acid halide in the presence of an excess organic base under specific temperature conditions through simple procedures.
CONSTITUTION: 5-Fluorouracil (F) is reacted with an aromatic acid halide, e.g. o-toluyl or benzoyl chloride, in the presence of an organic base in excess, preferably in a molar amount of twice that of F at 50°C or below, preferably room temperature or below, to give a 5-fluorouracil derivative, e.g. o-toluyl-5-fluorouracil, of the formula (R1 is acyl; R2 is H or acyl). Pyridine and triethylamine may be used as the base for preparing a 3-substituted 5-fluorouracil derivative and a 1,3-disubstituted-5-fluorouracil derivative, respectively.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1500979A JPS55108857A (en) | 1979-02-14 | 1979-02-14 | Preparation of 5-fluorouracil derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1500979A JPS55108857A (en) | 1979-02-14 | 1979-02-14 | Preparation of 5-fluorouracil derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55108857A true JPS55108857A (en) | 1980-08-21 |
Family
ID=11876876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1500979A Pending JPS55108857A (en) | 1979-02-14 | 1979-02-14 | Preparation of 5-fluorouracil derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55108857A (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5128637A (en) * | 1974-09-04 | 1976-03-11 | Tokyo Electric Power Co | Denryokukeito no hogohoshiki |
JPS5291880A (en) * | 1976-01-29 | 1977-08-02 | Mitsui Toatsu Chem Inc | 3-acyl-5-fluorouracil |
-
1979
- 1979-02-14 JP JP1500979A patent/JPS55108857A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5128637A (en) * | 1974-09-04 | 1976-03-11 | Tokyo Electric Power Co | Denryokukeito no hogohoshiki |
JPS5291880A (en) * | 1976-01-29 | 1977-08-02 | Mitsui Toatsu Chem Inc | 3-acyl-5-fluorouracil |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS55108857A (en) | Preparation of 5-fluorouracil derivative | |
JPS55164682A (en) | 1-alkyl-2-oxo-2h-1,8-naphthyridine derivative and its preparation | |
JPS51113882A (en) | Method for preparing 1-(alpha -alkoxyalkyl)-uracil derivatives | |
JPS5629526A (en) | Preparation of acylcyanide | |
JPS5673074A (en) | Preparation of imidazole | |
JPS5649398A (en) | Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine | |
JPS5520727A (en) | Preparation of 2-anilinophenyl acetate | |
JPS5740497A (en) | Preparation of 5-halogeno-2'-deoxyuridine | |
JPS5690064A (en) | Improved preparation of imidazole derivative | |
JPS5711975A (en) | Aminophenyltetrazole derivative and salt thereof | |
JPS5714598A (en) | 5-substituted-1-beta-d-arabinofuranosyluracil derivative and its preparation | |
JPS5651478A (en) | 3-carbamoyl-pyrazolo 1,5-a pyridine and its preparation | |
JPS5564575A (en) | Preparation of 3-acyl-5-fluorouracil | |
JPS5479286A (en) | Preparation of 5-fluoro-orotic acid | |
JPS54151971A (en) | Preparation of imidazole derivative | |
JPS54144320A (en) | Preparation of ureidomethylene malonic ester | |
JPS5695162A (en) | Novel synthesis of pantethine | |
JPS55118487A (en) | Novel preparation of xanthine derivative | |
JPS55108868A (en) | Dibenzoxepin derivative | |
JPS5589284A (en) | Preparation of xanthine derivative | |
JPS57171983A (en) | Aminophenyltetrazole derivative and salt thereof | |
JPS54106498A (en) | Carbostyril derivative | |
JPS5731685A (en) | Preparation of 2',3',5'-triacetoxy-5-fluorouridine | |
JPS5726675A (en) | Novel guanidinothiazole derivative and its preparation | |
JPS5673086A (en) | Preparation of cephalosporin compound |