JPS5673074A - Preparation of imidazole - Google Patents
Preparation of imidazoleInfo
- Publication number
- JPS5673074A JPS5673074A JP15021379A JP15021379A JPS5673074A JP S5673074 A JPS5673074 A JP S5673074A JP 15021379 A JP15021379 A JP 15021379A JP 15021379 A JP15021379 A JP 15021379A JP S5673074 A JPS5673074 A JP S5673074A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- triarylmethanol
- imidazolyl
- phosphine
- tri
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- HWOZVQNBUIBZMZ-UHFFFAOYSA-N tri(imidazol-1-yl)phosphane Chemical compound C1=NC=CN1P(N1C=NC=C1)N1C=NC=C1 HWOZVQNBUIBZMZ-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- LZTRCELOJRDYMQ-UHFFFAOYSA-N triphenylmethanol Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(O)C1=CC=CC=C1 LZTRCELOJRDYMQ-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound, useful as an agent, and having an antifungal activity readily in high yield, by reacting a triarylmethanol as a starting material with a tri-(1-imidazolyl)phosphine.
CONSTITUTION: A triarylmethanol (except a triphenylmethanol) is reacted with a tri-(1-imidazolyl)phosphine, preferably at a molar ratio between the latter and the former of 1 or more: 3, preferably 2/3:11-2:1, in a solvent, e.g. acetonitrile or chloroform, at room temperature or under heating to give the aimed compound. A compound of formula I (A, B and D are aromatic heterocyclic group or phenyl) may be cited as the starting triarylmethanol, and a compound of formula II (R1 and R2 and R3 are H, halogen, etc.) may be cited as the tri-(1-imidazolyl)phosphine.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15021379A JPS5673074A (en) | 1979-11-19 | 1979-11-19 | Preparation of imidazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15021379A JPS5673074A (en) | 1979-11-19 | 1979-11-19 | Preparation of imidazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5673074A true JPS5673074A (en) | 1981-06-17 |
Family
ID=15491997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15021379A Pending JPS5673074A (en) | 1979-11-19 | 1979-11-19 | Preparation of imidazole |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5673074A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4735960A (en) * | 1984-06-18 | 1988-04-05 | Eli Lilly And Company | Aromatase inhibitors |
-
1979
- 1979-11-19 JP JP15021379A patent/JPS5673074A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4735960A (en) * | 1984-06-18 | 1988-04-05 | Eli Lilly And Company | Aromatase inhibitors |
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