JPS55124760A - Preparation of 1,4-dihydropyridine derivative or its salt - Google Patents

Preparation of 1,4-dihydropyridine derivative or its salt

Info

Publication number
JPS55124760A
JPS55124760A JP3152179A JP3152179A JPS55124760A JP S55124760 A JPS55124760 A JP S55124760A JP 3152179 A JP3152179 A JP 3152179A JP 3152179 A JP3152179 A JP 3152179A JP S55124760 A JPS55124760 A JP S55124760A
Authority
JP
Japan
Prior art keywords
ammonium
formula
aldehyde
carbonate
compound shown
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3152179A
Other languages
Japanese (ja)
Other versions
JPS5730104B2 (en
Inventor
Kouji Inouchi
Toshio Uno
Goro Tsukamoto
Isamu Uchiumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP3152179A priority Critical patent/JPS55124760A/en
Publication of JPS55124760A publication Critical patent/JPS55124760A/en
Publication of JPS5730104B2 publication Critical patent/JPS5730104B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PURPOSE: To obtain the title compound in high purity and in stably high yields useful as vasodilators and hypotensors by reacting a β-ketocarboxylate with a aldehyde, ammonium hydrogen carbonate or ammonium cabonate.
CONSTITUTION: A compound shown by the formula I (R1 is lower alkyl; R2 is lower alkoxy, or lower alkyl) is reacted with an aldehyde shown by the formula II (R3 is phenyl, pyridyl, etc.) and ammonium hydrogen carbonate or ammonium carbonate (the former is better in respect to the purity of the desired compound) to give the desired compound shown by the formula III. A 1W4C alcohol, tetrahydrofuran, a mixed solvent of water with the solvents may be preferably cited as the reaction solvent. The molar ratios of ammonium (hydrogen) carbonate and the compound shown by the formula I to aldehyde is 1.0W3.0 and 2.0W4.0 respectively. The reaction temperature is 40W90°C.
COPYRIGHT: (C)1980,JPO&Japio
JP3152179A 1979-03-16 1979-03-16 Preparation of 1,4-dihydropyridine derivative or its salt Granted JPS55124760A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3152179A JPS55124760A (en) 1979-03-16 1979-03-16 Preparation of 1,4-dihydropyridine derivative or its salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3152179A JPS55124760A (en) 1979-03-16 1979-03-16 Preparation of 1,4-dihydropyridine derivative or its salt

Publications (2)

Publication Number Publication Date
JPS55124760A true JPS55124760A (en) 1980-09-26
JPS5730104B2 JPS5730104B2 (en) 1982-06-26

Family

ID=12333488

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3152179A Granted JPS55124760A (en) 1979-03-16 1979-03-16 Preparation of 1,4-dihydropyridine derivative or its salt

Country Status (1)

Country Link
JP (1) JPS55124760A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT380876B (en) * 1981-08-19 1986-07-25 Lek Tovarna Farmacevtskih METHOD FOR PRODUCING 4- (2'-NITROPHENYL) 2,6-DIMETHYL-3,5-DIMETHOXYCARBONYL-1,4-DIHYDROPYRIDINE
CN102382040A (en) * 2010-09-02 2012-03-21 常州市第四制药厂有限公司 Preparation of nifedipine and impurity separation method and application thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1177629B (en) * 1983-03-30 1987-08-26 Estee Lauder Inc AIR HERMETIC CONTAINER

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1173862A (en) * 1967-03-20 1969-12-10 Bayer Ag 4-Aryl-1,4-Dihydropyridine Derivatives and their production

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1173862A (en) * 1967-03-20 1969-12-10 Bayer Ag 4-Aryl-1,4-Dihydropyridine Derivatives and their production

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT380876B (en) * 1981-08-19 1986-07-25 Lek Tovarna Farmacevtskih METHOD FOR PRODUCING 4- (2'-NITROPHENYL) 2,6-DIMETHYL-3,5-DIMETHOXYCARBONYL-1,4-DIHYDROPYRIDINE
CN102382040A (en) * 2010-09-02 2012-03-21 常州市第四制药厂有限公司 Preparation of nifedipine and impurity separation method and application thereof

Also Published As

Publication number Publication date
JPS5730104B2 (en) 1982-06-26

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