JPS55124760A - Preparation of 1,4-dihydropyridine derivative or its salt - Google Patents
Preparation of 1,4-dihydropyridine derivative or its saltInfo
- Publication number
- JPS55124760A JPS55124760A JP3152179A JP3152179A JPS55124760A JP S55124760 A JPS55124760 A JP S55124760A JP 3152179 A JP3152179 A JP 3152179A JP 3152179 A JP3152179 A JP 3152179A JP S55124760 A JPS55124760 A JP S55124760A
- Authority
- JP
- Japan
- Prior art keywords
- ammonium
- formula
- aldehyde
- carbonate
- compound shown
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PURPOSE: To obtain the title compound in high purity and in stably high yields useful as vasodilators and hypotensors by reacting a β-ketocarboxylate with a aldehyde, ammonium hydrogen carbonate or ammonium cabonate.
CONSTITUTION: A compound shown by the formula I (R1 is lower alkyl; R2 is lower alkoxy, or lower alkyl) is reacted with an aldehyde shown by the formula II (R3 is phenyl, pyridyl, etc.) and ammonium hydrogen carbonate or ammonium carbonate (the former is better in respect to the purity of the desired compound) to give the desired compound shown by the formula III. A 1W4C alcohol, tetrahydrofuran, a mixed solvent of water with the solvents may be preferably cited as the reaction solvent. The molar ratios of ammonium (hydrogen) carbonate and the compound shown by the formula I to aldehyde is 1.0W3.0 and 2.0W4.0 respectively. The reaction temperature is 40W90°C.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3152179A JPS55124760A (en) | 1979-03-16 | 1979-03-16 | Preparation of 1,4-dihydropyridine derivative or its salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3152179A JPS55124760A (en) | 1979-03-16 | 1979-03-16 | Preparation of 1,4-dihydropyridine derivative or its salt |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55124760A true JPS55124760A (en) | 1980-09-26 |
JPS5730104B2 JPS5730104B2 (en) | 1982-06-26 |
Family
ID=12333488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3152179A Granted JPS55124760A (en) | 1979-03-16 | 1979-03-16 | Preparation of 1,4-dihydropyridine derivative or its salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55124760A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT380876B (en) * | 1981-08-19 | 1986-07-25 | Lek Tovarna Farmacevtskih | METHOD FOR PRODUCING 4- (2'-NITROPHENYL) 2,6-DIMETHYL-3,5-DIMETHOXYCARBONYL-1,4-DIHYDROPYRIDINE |
CN102382040A (en) * | 2010-09-02 | 2012-03-21 | 常州市第四制药厂有限公司 | Preparation of nifedipine and impurity separation method and application thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1177629B (en) * | 1983-03-30 | 1987-08-26 | Estee Lauder Inc | AIR HERMETIC CONTAINER |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1173862A (en) * | 1967-03-20 | 1969-12-10 | Bayer Ag | 4-Aryl-1,4-Dihydropyridine Derivatives and their production |
-
1979
- 1979-03-16 JP JP3152179A patent/JPS55124760A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1173862A (en) * | 1967-03-20 | 1969-12-10 | Bayer Ag | 4-Aryl-1,4-Dihydropyridine Derivatives and their production |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT380876B (en) * | 1981-08-19 | 1986-07-25 | Lek Tovarna Farmacevtskih | METHOD FOR PRODUCING 4- (2'-NITROPHENYL) 2,6-DIMETHYL-3,5-DIMETHOXYCARBONYL-1,4-DIHYDROPYRIDINE |
CN102382040A (en) * | 2010-09-02 | 2012-03-21 | 常州市第四制药厂有限公司 | Preparation of nifedipine and impurity separation method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS5730104B2 (en) | 1982-06-26 |
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