JPS5646873A - 2-guanidinothiazole derivative and its preparation - Google Patents

2-guanidinothiazole derivative and its preparation

Info

Publication number
JPS5646873A
JPS5646873A JP12351279A JP12351279A JPS5646873A JP S5646873 A JPS5646873 A JP S5646873A JP 12351279 A JP12351279 A JP 12351279A JP 12351279 A JP12351279 A JP 12351279A JP S5646873 A JPS5646873 A JP S5646873A
Authority
JP
Japan
Prior art keywords
formula
compound
preparation
salt
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12351279A
Other languages
Japanese (ja)
Other versions
JPS638943B2 (en
Inventor
Hidenori Iwamoto
Yasufumi Hirata
Isao Yanagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP12351279A priority Critical patent/JPS5646873A/en
Publication of JPS5646873A publication Critical patent/JPS5646873A/en
Publication of JPS638943B2 publication Critical patent/JPS638943B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 2-guanidinothiazole derivative of formula I (R is H or lower alkyl; m and n are 1W3) or its salt.
EXAMPLE: 3-(2-Guanidinothiazol-4-ylmethylthio)propionitrile.
USE: A synthetic intermediate of a compound having histamine H2 receptor antagonistic activity.
PROCESS: The compound of formula I can be prepared by reacting a compound of formula II (R' is lower alkyl) or its salt with stoichiometric or excess amount of an amine of formula R-NH2 in a solvent such as methanol, benzene, etc. at room temperature or an elevated temperature, usually under refluxing or at a higher temperature in a sealed tube.
COPYRIGHT: (C)1981,JPO&Japio
JP12351279A 1979-09-26 1979-09-26 2-guanidinothiazole derivative and its preparation Granted JPS5646873A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12351279A JPS5646873A (en) 1979-09-26 1979-09-26 2-guanidinothiazole derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12351279A JPS5646873A (en) 1979-09-26 1979-09-26 2-guanidinothiazole derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5646873A true JPS5646873A (en) 1981-04-28
JPS638943B2 JPS638943B2 (en) 1988-02-25

Family

ID=14862436

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12351279A Granted JPS5646873A (en) 1979-09-26 1979-09-26 2-guanidinothiazole derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5646873A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496564A (en) * 1981-03-09 1985-01-29 Ici Americas Inc. Amide derivatives
FR2569692A1 (en) * 1984-08-30 1986-03-07 Yamanouchi Pharma Co Ltd PROCESS FOR THE PREPARATION OF GUANIDINOTHIAZOLE DERIVATIVES

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496564A (en) * 1981-03-09 1985-01-29 Ici Americas Inc. Amide derivatives
FR2569692A1 (en) * 1984-08-30 1986-03-07 Yamanouchi Pharma Co Ltd PROCESS FOR THE PREPARATION OF GUANIDINOTHIAZOLE DERIVATIVES

Also Published As

Publication number Publication date
JPS638943B2 (en) 1988-02-25

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