JPS5646873A - 2-guanidinothiazole derivative and its preparation - Google Patents
2-guanidinothiazole derivative and its preparationInfo
- Publication number
- JPS5646873A JPS5646873A JP12351279A JP12351279A JPS5646873A JP S5646873 A JPS5646873 A JP S5646873A JP 12351279 A JP12351279 A JP 12351279A JP 12351279 A JP12351279 A JP 12351279A JP S5646873 A JPS5646873 A JP S5646873A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- preparation
- salt
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A 2-guanidinothiazole derivative of formula I (R is H or lower alkyl; m and n are 1W3) or its salt.
EXAMPLE: 3-(2-Guanidinothiazol-4-ylmethylthio)propionitrile.
USE: A synthetic intermediate of a compound having histamine H2 receptor antagonistic activity.
PROCESS: The compound of formula I can be prepared by reacting a compound of formula II (R' is lower alkyl) or its salt with stoichiometric or excess amount of an amine of formula R-NH2 in a solvent such as methanol, benzene, etc. at room temperature or an elevated temperature, usually under refluxing or at a higher temperature in a sealed tube.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12351279A JPS5646873A (en) | 1979-09-26 | 1979-09-26 | 2-guanidinothiazole derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12351279A JPS5646873A (en) | 1979-09-26 | 1979-09-26 | 2-guanidinothiazole derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5646873A true JPS5646873A (en) | 1981-04-28 |
JPS638943B2 JPS638943B2 (en) | 1988-02-25 |
Family
ID=14862436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12351279A Granted JPS5646873A (en) | 1979-09-26 | 1979-09-26 | 2-guanidinothiazole derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5646873A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4496564A (en) * | 1981-03-09 | 1985-01-29 | Ici Americas Inc. | Amide derivatives |
FR2569692A1 (en) * | 1984-08-30 | 1986-03-07 | Yamanouchi Pharma Co Ltd | PROCESS FOR THE PREPARATION OF GUANIDINOTHIAZOLE DERIVATIVES |
-
1979
- 1979-09-26 JP JP12351279A patent/JPS5646873A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4496564A (en) * | 1981-03-09 | 1985-01-29 | Ici Americas Inc. | Amide derivatives |
FR2569692A1 (en) * | 1984-08-30 | 1986-03-07 | Yamanouchi Pharma Co Ltd | PROCESS FOR THE PREPARATION OF GUANIDINOTHIAZOLE DERIVATIVES |
Also Published As
Publication number | Publication date |
---|---|
JPS638943B2 (en) | 1988-02-25 |
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