JPS54144400A - Preparation of rifamycin derivative - Google Patents
Preparation of rifamycin derivativeInfo
- Publication number
- JPS54144400A JPS54144400A JP5320578A JP5320578A JPS54144400A JP S54144400 A JPS54144400 A JP S54144400A JP 5320578 A JP5320578 A JP 5320578A JP 5320578 A JP5320578 A JP 5320578A JP S54144400 A JPS54144400 A JP S54144400A
- Authority
- JP
- Japan
- Prior art keywords
- rifamycin
- derivative
- iminomethyl
- preparation
- hcho
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PURPOSE: To prepare 3-iminomethyl derivative of rifamycin SV, easily, in high yield, by the two stage reaction from rifamycin B or O via 3-iminomethyl derivative of rifamycin S.
CONSTITUTION: Rifamycin B or rifamycin O is converted to 3-iminomethyl derivative of rifamycin S of formula I (R is alkyl) by reacting with HCHO and a primary amine or with an aldiimino derivative of HCHO and a primary amine, in the presence of an oxidizing agent. The reaction product (1 mole) is further made to react with (substituted-)hydrazine (≥2 moles) to afford the objective 3-iminomethyl derivative of rifamycin SV of formula II (R' is hydrozono, substituted hydrazono).
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5320578A JPS54144400A (en) | 1978-05-02 | 1978-05-02 | Preparation of rifamycin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5320578A JPS54144400A (en) | 1978-05-02 | 1978-05-02 | Preparation of rifamycin derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54144400A true JPS54144400A (en) | 1979-11-10 |
Family
ID=12936356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5320578A Pending JPS54144400A (en) | 1978-05-02 | 1978-05-02 | Preparation of rifamycin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54144400A (en) |
-
1978
- 1978-05-02 JP JP5320578A patent/JPS54144400A/en active Pending
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