JPS54144400A - Preparation of rifamycin derivative - Google Patents

Preparation of rifamycin derivative

Info

Publication number
JPS54144400A
JPS54144400A JP5320578A JP5320578A JPS54144400A JP S54144400 A JPS54144400 A JP S54144400A JP 5320578 A JP5320578 A JP 5320578A JP 5320578 A JP5320578 A JP 5320578A JP S54144400 A JPS54144400 A JP S54144400A
Authority
JP
Japan
Prior art keywords
rifamycin
derivative
iminomethyl
preparation
hcho
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5320578A
Other languages
Japanese (ja)
Inventor
Satoshi Ideguchi
Katsuji Yamashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Priority to JP5320578A priority Critical patent/JPS54144400A/en
Publication of JPS54144400A publication Critical patent/JPS54144400A/en
Pending legal-status Critical Current

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PURPOSE: To prepare 3-iminomethyl derivative of rifamycin SV, easily, in high yield, by the two stage reaction from rifamycin B or O via 3-iminomethyl derivative of rifamycin S.
CONSTITUTION: Rifamycin B or rifamycin O is converted to 3-iminomethyl derivative of rifamycin S of formula I (R is alkyl) by reacting with HCHO and a primary amine or with an aldiimino derivative of HCHO and a primary amine, in the presence of an oxidizing agent. The reaction product (1 mole) is further made to react with (substituted-)hydrazine (≥2 moles) to afford the objective 3-iminomethyl derivative of rifamycin SV of formula II (R' is hydrozono, substituted hydrazono).
COPYRIGHT: (C)1979,JPO&Japio
JP5320578A 1978-05-02 1978-05-02 Preparation of rifamycin derivative Pending JPS54144400A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5320578A JPS54144400A (en) 1978-05-02 1978-05-02 Preparation of rifamycin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5320578A JPS54144400A (en) 1978-05-02 1978-05-02 Preparation of rifamycin derivative

Publications (1)

Publication Number Publication Date
JPS54144400A true JPS54144400A (en) 1979-11-10

Family

ID=12936356

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5320578A Pending JPS54144400A (en) 1978-05-02 1978-05-02 Preparation of rifamycin derivative

Country Status (1)

Country Link
JP (1) JPS54144400A (en)

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