JPS57109794A - Preparation of cephalosporin analog - Google Patents

Preparation of cephalosporin analog

Info

Publication number
JPS57109794A
JPS57109794A JP18410480A JP18410480A JPS57109794A JP S57109794 A JPS57109794 A JP S57109794A JP 18410480 A JP18410480 A JP 18410480A JP 18410480 A JP18410480 A JP 18410480A JP S57109794 A JPS57109794 A JP S57109794A
Authority
JP
Japan
Prior art keywords
compound
formula
organic solvent
novel
cephalosporin analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18410480A
Other languages
Japanese (ja)
Inventor
Tadashi Hirata
Kenichi Mochida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP18410480A priority Critical patent/JPS57109794A/en
Publication of JPS57109794A publication Critical patent/JPS57109794A/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a synthetic intermediate for an antimicrobial agent from an inexpensive raw material easily in short steps, by reacting a novel azabicyclo compound with a metallic halogen compound in an organic solvent.
CONSTITUTION: A compound of formula III (X is phthalimide or azide; R is alkyl or aralkyl) is reduced in an organic solvent to give a novel compound of formula Ia, and if necessary the resultant compound of formula Ia is reacted with an active derivative of an organic sulfonic acid to afford a novel compound of formula Ib (Y' is alkylsulfonyl or arylsulfonyl). The resultant compound is then reacted with a metallic halogen compound in an organic solvent to afford a cephalosporin analog of formula II. The cephalosporin analog of formula II is useful as a synthetic intermediate for a carbacephalosporin derivative which is an antimicrobial agent.
COPYRIGHT: (C)1982,JPO&Japio
JP18410480A 1980-12-26 1980-12-26 Preparation of cephalosporin analog Pending JPS57109794A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18410480A JPS57109794A (en) 1980-12-26 1980-12-26 Preparation of cephalosporin analog

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18410480A JPS57109794A (en) 1980-12-26 1980-12-26 Preparation of cephalosporin analog

Publications (1)

Publication Number Publication Date
JPS57109794A true JPS57109794A (en) 1982-07-08

Family

ID=16147456

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18410480A Pending JPS57109794A (en) 1980-12-26 1980-12-26 Preparation of cephalosporin analog

Country Status (1)

Country Link
JP (1) JPS57109794A (en)

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