JPS57126477A - Preparation of nicotinic acid derivative - Google Patents

Preparation of nicotinic acid derivative

Info

Publication number
JPS57126477A
JPS57126477A JP1119481A JP1119481A JPS57126477A JP S57126477 A JPS57126477 A JP S57126477A JP 1119481 A JP1119481 A JP 1119481A JP 1119481 A JP1119481 A JP 1119481A JP S57126477 A JPS57126477 A JP S57126477A
Authority
JP
Japan
Prior art keywords
preparation
pyrrone
anilinomethylene
dihydro
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1119481A
Other languages
Japanese (ja)
Other versions
JPS6261031B2 (en
Inventor
Akira Kawamoto
Masahiro Yasaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kawaken Fine Chemicals Co Ltd
Original Assignee
Kawaken Fine Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kawaken Fine Chemicals Co Ltd filed Critical Kawaken Fine Chemicals Co Ltd
Priority to JP1119481A priority Critical patent/JPS57126477A/en
Publication of JPS57126477A publication Critical patent/JPS57126477A/en
Publication of JPS6261031B2 publication Critical patent/JPS6261031B2/ja
Granted legal-status Critical Current

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  • Pyridine Compounds (AREA)

Abstract

PURPOSE: To obtain 4-hydroxy-6-methylnicotinic acid useful as an intermediate for drugs industrially advantageously, by reacting 3-anilinomethylene-6-methyl-4- oxo-3,4-dihydro-2-pyrrone with ammonia.
CONSTITUTION: 1mol Compound shown by the formulaI(R1 is aryl; R2 is H, 1W3C alkyl, cycloalkyl), e.g., 3-anilinomethylene-6-methyl-4-oxo-3,4-dihydro-2- pyrrone is reacted with 2W4mol ammonia in a solvent such as methoxyethanol in a sealed tube or in an autoclave at 80W120°C, to give a compound shown by the formula II useful as an intermediate for drugs such as a cephalosporin derivative, etc. from industrially easily obtainable raw materials by one step without using expensive raw materials such as N,N-dimethylformamide methylacetal, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP1119481A 1981-01-27 1981-01-27 Preparation of nicotinic acid derivative Granted JPS57126477A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1119481A JPS57126477A (en) 1981-01-27 1981-01-27 Preparation of nicotinic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1119481A JPS57126477A (en) 1981-01-27 1981-01-27 Preparation of nicotinic acid derivative

Publications (2)

Publication Number Publication Date
JPS57126477A true JPS57126477A (en) 1982-08-06
JPS6261031B2 JPS6261031B2 (en) 1987-12-18

Family

ID=11771239

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1119481A Granted JPS57126477A (en) 1981-01-27 1981-01-27 Preparation of nicotinic acid derivative

Country Status (1)

Country Link
JP (1) JPS57126477A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59161359A (en) * 1983-03-07 1984-09-12 Tokuyama Soda Co Ltd Preparation of 3-hydroxypyridone compound

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59161359A (en) * 1983-03-07 1984-09-12 Tokuyama Soda Co Ltd Preparation of 3-hydroxypyridone compound
JPH0414106B2 (en) * 1983-03-07 1992-03-11 Tokuyama Soda Kk

Also Published As

Publication number Publication date
JPS6261031B2 (en) 1987-12-18

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