JPS55149257A - Novel preparation of isoindoline derivative - Google Patents

Novel preparation of isoindoline derivative

Info

Publication number
JPS55149257A
JPS55149257A JP4922379A JP4922379A JPS55149257A JP S55149257 A JPS55149257 A JP S55149257A JP 4922379 A JP4922379 A JP 4922379A JP 4922379 A JP4922379 A JP 4922379A JP S55149257 A JPS55149257 A JP S55149257A
Authority
JP
Japan
Prior art keywords
formula
derivative
isoindoline
methanol
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4922379A
Other languages
Japanese (ja)
Other versions
JPS603381B2 (en
Inventor
Kanji Noda
Akira Nakagawa
Toshiharu Motomura
Hiroyuki Ide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP4922379A priority Critical patent/JPS603381B2/en
Publication of JPS55149257A publication Critical patent/JPS55149257A/en
Publication of JPS603381B2 publication Critical patent/JPS603381B2/en
Expired legal-status Critical Current

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Abstract

PURPOSE: To obtain the titled compound useful as anti-inflammatory drugs, analgesics, etc. economically in high yields, by reacting an o-phthalaldehydic acid with an aniline derivative in a solvent, e.g., methanol, followed by only subjecting the resulted benzylidene derivative to ring formation in the presence of a reducing agent.
CONSTITUTION: o-Phthalaldehydic acid shown by the formula I is reacted with an aniline derivative shown by the formula II (R is H or 1W2C alkyl; X is carboxy, carboalkoxy, amido, or cyano) in a solvent, e.g., low priced methanol, to give a benzylidene derivative shown by the formula III, which is not isolated and subjected to ring formation in the presence of a reducing agent to prepare an isoindoline derivative shown by the formula IV, e.g., 1-oxo-2-[p-[(α-methyl)carboxymethyl] phnyl]-isoindoline, etc.
EFFECT: Since the reactions is carried out in one bath, the installation and operation for the reaction are simple.
COPYRIGHT: (C)1980,JPO&Japio
JP4922379A 1979-04-20 1979-04-20 Novel production method for isoindoline derivatives Expired JPS603381B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4922379A JPS603381B2 (en) 1979-04-20 1979-04-20 Novel production method for isoindoline derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4922379A JPS603381B2 (en) 1979-04-20 1979-04-20 Novel production method for isoindoline derivatives

Publications (2)

Publication Number Publication Date
JPS55149257A true JPS55149257A (en) 1980-11-20
JPS603381B2 JPS603381B2 (en) 1985-01-28

Family

ID=12824927

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4922379A Expired JPS603381B2 (en) 1979-04-20 1979-04-20 Novel production method for isoindoline derivatives

Country Status (1)

Country Link
JP (1) JPS603381B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750961A (en) * 1980-09-10 1982-03-25 Hisamitsu Pharmaceut Co Inc Novel preparation of isoindoline derivative
CN106397298A (en) * 2016-08-11 2017-02-15 杭州中美华东制药有限公司 A pharmaceutical composition containing indobufen and uses thereof
CN115850154A (en) * 2022-12-29 2023-03-28 山东京卫制药有限公司 Preparation method of indobufen

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62176579U (en) * 1986-04-30 1987-11-10

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750961A (en) * 1980-09-10 1982-03-25 Hisamitsu Pharmaceut Co Inc Novel preparation of isoindoline derivative
CN106397298A (en) * 2016-08-11 2017-02-15 杭州中美华东制药有限公司 A pharmaceutical composition containing indobufen and uses thereof
CN115850154A (en) * 2022-12-29 2023-03-28 山东京卫制药有限公司 Preparation method of indobufen

Also Published As

Publication number Publication date
JPS603381B2 (en) 1985-01-28

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