JPS5718667A - Preparation of aporphine compound - Google Patents

Preparation of aporphine compound

Info

Publication number
JPS5718667A
JPS5718667A JP9331980A JP9331980A JPS5718667A JP S5718667 A JPS5718667 A JP S5718667A JP 9331980 A JP9331980 A JP 9331980A JP 9331980 A JP9331980 A JP 9331980A JP S5718667 A JPS5718667 A JP S5718667A
Authority
JP
Japan
Prior art keywords
solvent
oxide
isoquinoline derivative
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9331980A
Other languages
Japanese (ja)
Inventor
Tetsuji Kametani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SENDAI FUKUSOKAN KAGAKU KENKYU
SENDAI FUKUSOKAN KAGAKU KENKYUSHO
Original Assignee
SENDAI FUKUSOKAN KAGAKU KENKYU
SENDAI FUKUSOKAN KAGAKU KENKYUSHO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SENDAI FUKUSOKAN KAGAKU KENKYU, SENDAI FUKUSOKAN KAGAKU KENKYUSHO filed Critical SENDAI FUKUSOKAN KAGAKU KENKYU
Priority to JP9331980A priority Critical patent/JPS5718667A/en
Publication of JPS5718667A publication Critical patent/JPS5718667A/en
Pending legal-status Critical Current

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Abstract

PURPOSE: To obtain the titled substance useful as an analgesic, and anti-inflammatory agent, etc. in a short step in high yield, by reacting N-oxide of an isoquinoline derivative with cuprous chloride in a solvent.
CONSTITUTION: N-Oxide of an isoquinoline derivative expressed by formula I (R1 is lower alkyl; n is 2) is reacted with cuprous chloride in a molar amount of 0.1W6 times that of the N-oxide of the isoquinoline derivative in a solvent at 0W80°C for 1W78hr to give a compound expressed by formula II (R2 and R3 are H or OH). A solvent having no direct influence on the reaction is usable, and preferably a lower alkyl alcohol, more preferably methanol, is used.
COPYRIGHT: (C)1982,JPO&Japio
JP9331980A 1980-07-10 1980-07-10 Preparation of aporphine compound Pending JPS5718667A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9331980A JPS5718667A (en) 1980-07-10 1980-07-10 Preparation of aporphine compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9331980A JPS5718667A (en) 1980-07-10 1980-07-10 Preparation of aporphine compound

Publications (1)

Publication Number Publication Date
JPS5718667A true JPS5718667A (en) 1982-01-30

Family

ID=14078966

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9331980A Pending JPS5718667A (en) 1980-07-10 1980-07-10 Preparation of aporphine compound

Country Status (1)

Country Link
JP (1) JPS5718667A (en)

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