JPS5718667A - Preparation of aporphine compound - Google Patents
Preparation of aporphine compoundInfo
- Publication number
- JPS5718667A JPS5718667A JP9331980A JP9331980A JPS5718667A JP S5718667 A JPS5718667 A JP S5718667A JP 9331980 A JP9331980 A JP 9331980A JP 9331980 A JP9331980 A JP 9331980A JP S5718667 A JPS5718667 A JP S5718667A
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- oxide
- isoquinoline derivative
- preparation
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
PURPOSE: To obtain the titled substance useful as an analgesic, and anti-inflammatory agent, etc. in a short step in high yield, by reacting N-oxide of an isoquinoline derivative with cuprous chloride in a solvent.
CONSTITUTION: N-Oxide of an isoquinoline derivative expressed by formula I (R1 is lower alkyl; n is 2) is reacted with cuprous chloride in a molar amount of 0.1W6 times that of the N-oxide of the isoquinoline derivative in a solvent at 0W80°C for 1W78hr to give a compound expressed by formula II (R2 and R3 are H or OH). A solvent having no direct influence on the reaction is usable, and preferably a lower alkyl alcohol, more preferably methanol, is used.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9331980A JPS5718667A (en) | 1980-07-10 | 1980-07-10 | Preparation of aporphine compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9331980A JPS5718667A (en) | 1980-07-10 | 1980-07-10 | Preparation of aporphine compound |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5718667A true JPS5718667A (en) | 1982-01-30 |
Family
ID=14078966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9331980A Pending JPS5718667A (en) | 1980-07-10 | 1980-07-10 | Preparation of aporphine compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5718667A (en) |
-
1980
- 1980-07-10 JP JP9331980A patent/JPS5718667A/en active Pending
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