JPS56103197A - Novel d-glucose derivative and antitumor agent containing the same as active constitutent - Google Patents
Novel d-glucose derivative and antitumor agent containing the same as active constitutentInfo
- Publication number
- JPS56103197A JPS56103197A JP451980A JP451980A JPS56103197A JP S56103197 A JPS56103197 A JP S56103197A JP 451980 A JP451980 A JP 451980A JP 451980 A JP451980 A JP 451980A JP S56103197 A JPS56103197 A JP S56103197A
- Authority
- JP
- Japan
- Prior art keywords
- antitumor agent
- novel
- same
- agent containing
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound expressed by formula I (R is H or acetyl; R' is formula II).
EXAMPLE: 3-Deoxy-3-(3-methyl-3-nitrosoureido)-D-glucose.
USE: An antitumor agent and a remedy for leukemia.
PROCESS: 3-Deoxy-3-( 3-methyl-3-nitrosoureido )- 1,2 : 5,6 -di-0-isopropylidene-α- D-glucofuranose expressed by formula III is dissolved in trifluoroacetic acid, etc., allowed to stand at room temperature and hydrolyzed. The resultant hydrolysis product is then concentrated in vacuo to give an oily residue. The residue is dissolved in methanol and purified by the liquid chromatography with a chloroform -methanol mixture, etc. as a developing solvent to affort and aimed compound.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP451980A JPS56103197A (en) | 1980-01-21 | 1980-01-21 | Novel d-glucose derivative and antitumor agent containing the same as active constitutent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP451980A JPS56103197A (en) | 1980-01-21 | 1980-01-21 | Novel d-glucose derivative and antitumor agent containing the same as active constitutent |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56103197A true JPS56103197A (en) | 1981-08-18 |
Family
ID=11586290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP451980A Pending JPS56103197A (en) | 1980-01-21 | 1980-01-21 | Novel d-glucose derivative and antitumor agent containing the same as active constitutent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56103197A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0247428A2 (en) * | 1986-05-23 | 1987-12-02 | Bayer Ag | Carbohydrate containing dichloromethylenimino radicals, and method for their preparation |
WO2010005799A3 (en) * | 2008-07-11 | 2010-04-29 | Board Of Regents, The University Of Texas System | Novel acetates of 2-deoxy monosaccharides with anticancer activity |
US10201554B2 (en) | 2013-04-05 | 2019-02-12 | Board Of Regents, The University Of Texas System | Esters of 2-deoxy-monosacharides with anti proliferative activity |
-
1980
- 1980-01-21 JP JP451980A patent/JPS56103197A/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0247428A2 (en) * | 1986-05-23 | 1987-12-02 | Bayer Ag | Carbohydrate containing dichloromethylenimino radicals, and method for their preparation |
EP0247428A3 (en) * | 1986-05-23 | 1989-11-15 | Bayer Ag | Carbohydrate containing dichloromethylenimino radicals, and method for their preparation |
WO2010005799A3 (en) * | 2008-07-11 | 2010-04-29 | Board Of Regents, The University Of Texas System | Novel acetates of 2-deoxy monosaccharides with anticancer activity |
US8927506B2 (en) | 2008-07-11 | 2015-01-06 | Board Of Regents, The University Of Texas System | Acetates of 2-deoxy monosaccharides with anticancer activity |
US10201554B2 (en) | 2013-04-05 | 2019-02-12 | Board Of Regents, The University Of Texas System | Esters of 2-deoxy-monosacharides with anti proliferative activity |
US11026960B2 (en) | 2013-04-05 | 2021-06-08 | Board Of Regents, The University Of Texas System | Esters of 2-deoxy-monosaccharides with anti proliferative activity |
US11925654B2 (en) | 2013-04-05 | 2024-03-12 | Board Of Regents, The University Of Texas System | Esters of 2-deoxy-monosaccharides with anti proliferative activity |
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