JPS56103197A - Novel d-glucose derivative and antitumor agent containing the same as active constitutent - Google Patents

Novel d-glucose derivative and antitumor agent containing the same as active constitutent

Info

Publication number
JPS56103197A
JPS56103197A JP451980A JP451980A JPS56103197A JP S56103197 A JPS56103197 A JP S56103197A JP 451980 A JP451980 A JP 451980A JP 451980 A JP451980 A JP 451980A JP S56103197 A JPS56103197 A JP S56103197A
Authority
JP
Japan
Prior art keywords
antitumor agent
novel
same
agent containing
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP451980A
Other languages
Japanese (ja)
Inventor
Masahide Yamada
Kenichi Enami
Toshio Kuroda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wakamoto Pharmaceutical Co Ltd
Original Assignee
Wakamoto Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wakamoto Pharmaceutical Co Ltd filed Critical Wakamoto Pharmaceutical Co Ltd
Priority to JP451980A priority Critical patent/JPS56103197A/en
Publication of JPS56103197A publication Critical patent/JPS56103197A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound expressed by formula I (R is H or acetyl; R' is formula II).
EXAMPLE: 3-Deoxy-3-(3-methyl-3-nitrosoureido)-D-glucose.
USE: An antitumor agent and a remedy for leukemia.
PROCESS: 3-Deoxy-3-( 3-methyl-3-nitrosoureido )- 1,2 : 5,6 -di-0-isopropylidene-α- D-glucofuranose expressed by formula III is dissolved in trifluoroacetic acid, etc., allowed to stand at room temperature and hydrolyzed. The resultant hydrolysis product is then concentrated in vacuo to give an oily residue. The residue is dissolved in methanol and purified by the liquid chromatography with a chloroform -methanol mixture, etc. as a developing solvent to affort and aimed compound.
COPYRIGHT: (C)1981,JPO&Japio
JP451980A 1980-01-21 1980-01-21 Novel d-glucose derivative and antitumor agent containing the same as active constitutent Pending JPS56103197A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP451980A JPS56103197A (en) 1980-01-21 1980-01-21 Novel d-glucose derivative and antitumor agent containing the same as active constitutent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP451980A JPS56103197A (en) 1980-01-21 1980-01-21 Novel d-glucose derivative and antitumor agent containing the same as active constitutent

Publications (1)

Publication Number Publication Date
JPS56103197A true JPS56103197A (en) 1981-08-18

Family

ID=11586290

Family Applications (1)

Application Number Title Priority Date Filing Date
JP451980A Pending JPS56103197A (en) 1980-01-21 1980-01-21 Novel d-glucose derivative and antitumor agent containing the same as active constitutent

Country Status (1)

Country Link
JP (1) JPS56103197A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247428A2 (en) * 1986-05-23 1987-12-02 Bayer Ag Carbohydrate containing dichloromethylenimino radicals, and method for their preparation
WO2010005799A3 (en) * 2008-07-11 2010-04-29 Board Of Regents, The University Of Texas System Novel acetates of 2-deoxy monosaccharides with anticancer activity
US10201554B2 (en) 2013-04-05 2019-02-12 Board Of Regents, The University Of Texas System Esters of 2-deoxy-monosacharides with anti proliferative activity

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247428A2 (en) * 1986-05-23 1987-12-02 Bayer Ag Carbohydrate containing dichloromethylenimino radicals, and method for their preparation
EP0247428A3 (en) * 1986-05-23 1989-11-15 Bayer Ag Carbohydrate containing dichloromethylenimino radicals, and method for their preparation
WO2010005799A3 (en) * 2008-07-11 2010-04-29 Board Of Regents, The University Of Texas System Novel acetates of 2-deoxy monosaccharides with anticancer activity
US8927506B2 (en) 2008-07-11 2015-01-06 Board Of Regents, The University Of Texas System Acetates of 2-deoxy monosaccharides with anticancer activity
US10201554B2 (en) 2013-04-05 2019-02-12 Board Of Regents, The University Of Texas System Esters of 2-deoxy-monosacharides with anti proliferative activity
US11026960B2 (en) 2013-04-05 2021-06-08 Board Of Regents, The University Of Texas System Esters of 2-deoxy-monosaccharides with anti proliferative activity
US11925654B2 (en) 2013-04-05 2024-03-12 Board Of Regents, The University Of Texas System Esters of 2-deoxy-monosaccharides with anti proliferative activity

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