JPS5598176A - Novel phthalide derivative - Google Patents

Novel phthalide derivative

Info

Publication number
JPS5598176A
JPS5598176A JP473679A JP473679A JPS5598176A JP S5598176 A JPS5598176 A JP S5598176A JP 473679 A JP473679 A JP 473679A JP 473679 A JP473679 A JP 473679A JP S5598176 A JPS5598176 A JP S5598176A
Authority
JP
Japan
Prior art keywords
formula
derivative
compound
diester
phthalide derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP473679A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Hiromichi Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP473679A priority Critical patent/JPS5598176A/en
Publication of JPS5598176A publication Critical patent/JPS5598176A/en
Pending legal-status Critical Current

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Abstract

NEW MATERIAL:A phthalide derivative of formula I (R1, R2, and R3 may be the same or different alkyl groups).
EXAMPLE: 6-Ethoxycarbonyl-5,7-dimethylphthalide.
USE: An intermediate for the synthesis of 2-phenyl-1-phthalazone derivatives having thromboxane biosynthesis inhibitory and antithrombotic actions.
PROCESS: A reactive derivative of the carboxylic acid compound of formula I is reduced with a boron hydride complex, preferably sodium borohydride, in the presence of a dehydrochlorinating agent, e.g. triethylamine, in a solvent, e.g. tetrahydrofuran, to give the compound of formula I. The starting compound of formula II can be obtained by partial hydrolysis of a phthalic diester derivative prepared through the Dieles-Alder reaction of an isodehydroacetate with an acetylenedicarboxylic diester.
COPYRIGHT: (C)1980,JPO&Japio
JP473679A 1979-01-22 1979-01-22 Novel phthalide derivative Pending JPS5598176A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP473679A JPS5598176A (en) 1979-01-22 1979-01-22 Novel phthalide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP473679A JPS5598176A (en) 1979-01-22 1979-01-22 Novel phthalide derivative

Publications (1)

Publication Number Publication Date
JPS5598176A true JPS5598176A (en) 1980-07-25

Family

ID=11592185

Family Applications (1)

Application Number Title Priority Date Filing Date
JP473679A Pending JPS5598176A (en) 1979-01-22 1979-01-22 Novel phthalide derivative

Country Status (1)

Country Link
JP (1) JPS5598176A (en)

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