JPS579749A - Acyl derivative and its preparation - Google Patents
Acyl derivative and its preparationInfo
- Publication number
- JPS579749A JPS579749A JP8252980A JP8252980A JPS579749A JP S579749 A JPS579749 A JP S579749A JP 8252980 A JP8252980 A JP 8252980A JP 8252980 A JP8252980 A JP 8252980A JP S579749 A JPS579749 A JP S579749A
- Authority
- JP
- Japan
- Prior art keywords
- neocarzinostatin
- formula
- puleneocarzinostatin
- residue
- acyl derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002252 acyl group Chemical group 0.000 title abstract 3
- QZGIWPZCWHMVQL-UIYAJPBUSA-N neocarzinostatin chromophore Chemical group O1[C@H](C)[C@H](O)[C@H](O)[C@@H](NC)[C@H]1O[C@@H]1C/2=C/C#C[C@H]3O[C@@]3([C@@H]3OC(=O)OC3)C#CC\2=C[C@H]1OC(=O)C1=C(O)C=CC2=C(C)C=C(OC)C=C12 QZGIWPZCWHMVQL-UIYAJPBUSA-N 0.000 abstract 3
- 229950009268 zinostatin Drugs 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 101710204212 Neocarzinostatin Proteins 0.000 abstract 2
- 230000003327 cancerostatic effect Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- -1 e.g. Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
NEW MATERIAL:An acyl derivative shown by the formula I (A is neocarzinostatin residue or puleneocarzinostatin residue; R is saturated or unsaturated acyl; n is 1 or 2).
EXAMPLE: Monomyristoyl-neocarzinostatin.
USE: A carcinostatic agent or its synthetic intermediate. Neocarzinostatin is acylated, so that the toxicity is characteristically reduced without damaging its carcinostatic effects.
PROCESS: For example, a neocarzinostatin or puleneocarzinostatin shown by the formula II is reacted with a carboxylic acid shown by the formula III or its reactive derivative, to give a compound shown by the formula I. The reaction is carried out in a solvent, e.g., water, acetone, etc., and, if necessary, in the presence of a condensation agent.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8252980A JPS579749A (en) | 1980-06-18 | 1980-06-18 | Acyl derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8252980A JPS579749A (en) | 1980-06-18 | 1980-06-18 | Acyl derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS579749A true JPS579749A (en) | 1982-01-19 |
| JPS6342640B2 JPS6342640B2 (en) | 1988-08-24 |
Family
ID=13777031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8252980A Granted JPS579749A (en) | 1980-06-18 | 1980-06-18 | Acyl derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS579749A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58187411A (en) * | 1982-04-27 | 1983-11-01 | Hitachi Chem Co Ltd | Production of shock-resistant thermoplastic resin |
| JPS5951906A (en) * | 1982-09-16 | 1984-03-26 | Sumitomo Chem Co Ltd | Production of graft copolymer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5159801A (en) * | 1974-11-18 | 1976-05-25 | Koyama Yasuo |
-
1980
- 1980-06-18 JP JP8252980A patent/JPS579749A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5159801A (en) * | 1974-11-18 | 1976-05-25 | Koyama Yasuo |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58187411A (en) * | 1982-04-27 | 1983-11-01 | Hitachi Chem Co Ltd | Production of shock-resistant thermoplastic resin |
| JPS6354729B2 (en) * | 1982-04-27 | 1988-10-31 | Hitachi Chemical Co Ltd | |
| JPS5951906A (en) * | 1982-09-16 | 1984-03-26 | Sumitomo Chem Co Ltd | Production of graft copolymer |
| JPS6333764B2 (en) * | 1982-09-16 | 1988-07-06 | Sumitomo Chemical Co |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6342640B2 (en) | 1988-08-24 |
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