JPS56128769A - Amino-5-fluorouracil derivative and its preparation - Google Patents
Amino-5-fluorouracil derivative and its preparationInfo
- Publication number
- JPS56128769A JPS56128769A JP3177680A JP3177680A JPS56128769A JP S56128769 A JPS56128769 A JP S56128769A JP 3177680 A JP3177680 A JP 3177680A JP 3177680 A JP3177680 A JP 3177680A JP S56128769 A JPS56128769 A JP S56128769A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouracil
- amino
- preparation
- arylsulfonylamino
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A amino-5-fluorouracil derivative of the formula (R1 is lower acylamino or arylsulfonylamino; R2 is H or arylsulfonylamino).
EXAMPLE: 3-Butyrylamino-5-fluorouracil.
USE: An antitumor agent.
PROCESS: 5-Fluorouracil is reacted with an aminating agent, e.g. O-mesitylenesulfonylhydroxyamine, to give a reaction product, which is then reacted with one type selected from a lower acyl halide, an aliphatic carboxylic acid anhydride and arylsulfonyl halide to afford the compound of the formula. The amination reaction is suitably carried out by using about 1W10mol aminating agent based on 1mol 5-fluorouracil.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3177680A JPS56128769A (en) | 1980-03-12 | 1980-03-12 | Amino-5-fluorouracil derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3177680A JPS56128769A (en) | 1980-03-12 | 1980-03-12 | Amino-5-fluorouracil derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56128769A true JPS56128769A (en) | 1981-10-08 |
JPS626712B2 JPS626712B2 (en) | 1987-02-13 |
Family
ID=12340447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3177680A Granted JPS56128769A (en) | 1980-03-12 | 1980-03-12 | Amino-5-fluorouracil derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56128769A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006135312A1 (en) * | 2005-06-17 | 2006-12-21 | Astrazeneca Ab | Trombin inhibiting 2,4-dioxo-3,4-dihydropyrimidine derivatives |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0266811U (en) * | 1988-11-09 | 1990-05-21 |
-
1980
- 1980-03-12 JP JP3177680A patent/JPS56128769A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006135312A1 (en) * | 2005-06-17 | 2006-12-21 | Astrazeneca Ab | Trombin inhibiting 2,4-dioxo-3,4-dihydropyrimidine derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS626712B2 (en) | 1987-02-13 |
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