JPS56128769A - Amino-5-fluorouracil derivative and its preparation - Google Patents

Amino-5-fluorouracil derivative and its preparation

Info

Publication number
JPS56128769A
JPS56128769A JP3177680A JP3177680A JPS56128769A JP S56128769 A JPS56128769 A JP S56128769A JP 3177680 A JP3177680 A JP 3177680A JP 3177680 A JP3177680 A JP 3177680A JP S56128769 A JPS56128769 A JP S56128769A
Authority
JP
Japan
Prior art keywords
fluorouracil
amino
preparation
arylsulfonylamino
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3177680A
Other languages
Japanese (ja)
Other versions
JPS626712B2 (en
Inventor
Junichi Yamashita
Sanji Yasumoto
Sadao Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP3177680A priority Critical patent/JPS56128769A/en
Publication of JPS56128769A publication Critical patent/JPS56128769A/en
Publication of JPS626712B2 publication Critical patent/JPS626712B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A amino-5-fluorouracil derivative of the formula (R1 is lower acylamino or arylsulfonylamino; R2 is H or arylsulfonylamino).
EXAMPLE: 3-Butyrylamino-5-fluorouracil.
USE: An antitumor agent.
PROCESS: 5-Fluorouracil is reacted with an aminating agent, e.g. O-mesitylenesulfonylhydroxyamine, to give a reaction product, which is then reacted with one type selected from a lower acyl halide, an aliphatic carboxylic acid anhydride and arylsulfonyl halide to afford the compound of the formula. The amination reaction is suitably carried out by using about 1W10mol aminating agent based on 1mol 5-fluorouracil.
COPYRIGHT: (C)1981,JPO&Japio
JP3177680A 1980-03-12 1980-03-12 Amino-5-fluorouracil derivative and its preparation Granted JPS56128769A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3177680A JPS56128769A (en) 1980-03-12 1980-03-12 Amino-5-fluorouracil derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3177680A JPS56128769A (en) 1980-03-12 1980-03-12 Amino-5-fluorouracil derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS56128769A true JPS56128769A (en) 1981-10-08
JPS626712B2 JPS626712B2 (en) 1987-02-13

Family

ID=12340447

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3177680A Granted JPS56128769A (en) 1980-03-12 1980-03-12 Amino-5-fluorouracil derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS56128769A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006135312A1 (en) * 2005-06-17 2006-12-21 Astrazeneca Ab Trombin inhibiting 2,4-dioxo-3,4-dihydropyrimidine derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0266811U (en) * 1988-11-09 1990-05-21

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006135312A1 (en) * 2005-06-17 2006-12-21 Astrazeneca Ab Trombin inhibiting 2,4-dioxo-3,4-dihydropyrimidine derivatives

Also Published As

Publication number Publication date
JPS626712B2 (en) 1987-02-13

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