JPS5782352A - Glutamine derivative - Google Patents

Glutamine derivative

Info

Publication number
JPS5782352A
JPS5782352A JP55159319A JP15931980A JPS5782352A JP S5782352 A JPS5782352 A JP S5782352A JP 55159319 A JP55159319 A JP 55159319A JP 15931980 A JP15931980 A JP 15931980A JP S5782352 A JPS5782352 A JP S5782352A
Authority
JP
Japan
Prior art keywords
formula
glutamine
lower alkyl
amino
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55159319A
Other languages
Japanese (ja)
Other versions
JPS6027660B2 (en
Inventor
Hiroaki Munakata
Makio Kobayashi
Kazuo Azuma
Shigeru Sato
Makoto Tsurufuji
Shingo Matsumura
Hiroshi Enomoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Nippon Shinyaku Co Ltd
Original Assignee
Mitsubishi Kasei Corp
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp, Nippon Shinyaku Co Ltd filed Critical Mitsubishi Kasei Corp
Priority to JP55159319A priority Critical patent/JPS6027660B2/en
Priority to DE8181109431T priority patent/DE3164463D1/en
Priority to AT81109431T priority patent/ATE8131T1/en
Priority to EP81109431A priority patent/EP0052296B1/en
Priority to US06/319,992 priority patent/US4439448A/en
Priority to DK500081A priority patent/DK159149C/en
Priority to CA000389865A priority patent/CA1190240A/en
Priority to KR1019810004352A priority patent/KR860001887B1/en
Publication of JPS5782352A publication Critical patent/JPS5782352A/en
Publication of JPS6027660B2 publication Critical patent/JPS6027660B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A glutamine derivative shown by the formula I[X is an alkylene shown by the formula II (n is 1W4) or vinylene; Z is H or lower alkyl] and its nontoxic salt.
EXAMPLE: N-(4-Ethoxycarbonylmethylphenyl)-L-glutamine.
USE: An immune regulating agent useful for remedying and preventing various kinds of disease caused by an immune reaction. Useful as a remedy for autoimmune diseases, e.g., rheumatoid arthritis, etc., and bacterium infectious diseases. Having low toxicity.
PROCESS: Glutamic acid anhydride with its amino group protected is reacted with an aniline derivative shown by the formula III (Y is lower alkyl) in the presence of an activator, and the amino-protecting group is removed from the reaction product, to give a compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP55159319A 1980-11-12 1980-11-12 glutamine derivative Expired JPS6027660B2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP55159319A JPS6027660B2 (en) 1980-11-12 1980-11-12 glutamine derivative
DE8181109431T DE3164463D1 (en) 1980-11-12 1981-10-30 Glutamine derivatives usable for curing immune diseases, methods for their preparation and compositions comprising said derivatives
AT81109431T ATE8131T1 (en) 1980-11-12 1981-10-30 GLUTAMINE DERIVATIVES APPLICABLE AS IMMUNE DISEASE CURE, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS INCLUDING THE ABOVE-MENTIONED DERIVATIVES.
EP81109431A EP0052296B1 (en) 1980-11-12 1981-10-30 Glutamine derivatives usable for curing immune diseases, methods for their preparation and compositions comprising said derivatives
US06/319,992 US4439448A (en) 1980-11-12 1981-11-10 Glutamine derivatives
DK500081A DK159149C (en) 1980-11-12 1981-11-11 ANALOGY PROCEDURE FOR THE PREPARATION OF GLUTAMINE DERIVATIVES.
CA000389865A CA1190240A (en) 1980-11-12 1981-11-12 Glutamine derivatives
KR1019810004352A KR860001887B1 (en) 1980-11-12 1981-11-12 A process for preparing glutamine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55159319A JPS6027660B2 (en) 1980-11-12 1980-11-12 glutamine derivative

Publications (2)

Publication Number Publication Date
JPS5782352A true JPS5782352A (en) 1982-05-22
JPS6027660B2 JPS6027660B2 (en) 1985-06-29

Family

ID=15691191

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55159319A Expired JPS6027660B2 (en) 1980-11-12 1980-11-12 glutamine derivative

Country Status (1)

Country Link
JP (1) JPS6027660B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016523818A (en) * 2013-04-18 2016-08-12 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Methods and pharmaceutical compositions (CTPS1 inhibitors such as norleucine) for inhibiting T cell proliferation in a subject in need thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016523818A (en) * 2013-04-18 2016-08-12 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Methods and pharmaceutical compositions (CTPS1 inhibitors such as norleucine) for inhibiting T cell proliferation in a subject in need thereof

Also Published As

Publication number Publication date
JPS6027660B2 (en) 1985-06-29

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