JPS56131554A - Novel d-glutamic acid derivative, its preparation, and immunizing agent containing said derivative as effective component - Google Patents

Novel d-glutamic acid derivative, its preparation, and immunizing agent containing said derivative as effective component

Info

Publication number
JPS56131554A
JPS56131554A JP3261080A JP3261080A JPS56131554A JP S56131554 A JPS56131554 A JP S56131554A JP 3261080 A JP3261080 A JP 3261080A JP 3261080 A JP3261080 A JP 3261080A JP S56131554 A JPS56131554 A JP S56131554A
Authority
JP
Japan
Prior art keywords
glutamic acid
formula
derivative
acid derivative
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3261080A
Other languages
Japanese (ja)
Other versions
JPS6338985B2 (en
Inventor
Katsuyuki Zama
Muneharu Suzuki
Yukio Inoue
Takaharu Sekine
Katsuo Momoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Kaken Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd, Kaken Chemical Co Ltd filed Critical Kaken Pharmaceutical Co Ltd
Priority to JP3261080A priority Critical patent/JPS56131554A/en
Publication of JPS56131554A publication Critical patent/JPS56131554A/en
Publication of JPS6338985B2 publication Critical patent/JPS6338985B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A D-glutamic acid derivative of formula I [one or R1 and R2 is OH and the other is group of formula II (R3 is H or alkyl; R4 is alkyl, cycloaklyl, aryl or aralkyl, or R3 and R4 together form alkylene group)].
EXAMPLE: D-glutamic acid α-isopropylamide.
USE: Useful for remedy and prevention of various diseases caused by immunological reactions. It has low toxicity. The compound can be used as an immunosuppressive agent to the rejection symptoms in the transplantation of organs such as the kidney, skin, etc., and autoimmune diseases such as diseases of thyroid gland, chronic arthrorheumatism, gastric diseases, etc., and as an immunopromoting agent to tumor, etc.
PROCESS: A D-glutamic acid derivative wherein the amino group and one of the carboxyl groups are protected is made to react with an amine of formula III in the presence of a condensing agent, and the protecting groups are eliminated from the reaction product to afford the objective compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP3261080A 1980-03-17 1980-03-17 Novel d-glutamic acid derivative, its preparation, and immunizing agent containing said derivative as effective component Granted JPS56131554A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3261080A JPS56131554A (en) 1980-03-17 1980-03-17 Novel d-glutamic acid derivative, its preparation, and immunizing agent containing said derivative as effective component

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3261080A JPS56131554A (en) 1980-03-17 1980-03-17 Novel d-glutamic acid derivative, its preparation, and immunizing agent containing said derivative as effective component

Publications (2)

Publication Number Publication Date
JPS56131554A true JPS56131554A (en) 1981-10-15
JPS6338985B2 JPS6338985B2 (en) 1988-08-03

Family

ID=12363617

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3261080A Granted JPS56131554A (en) 1980-03-17 1980-03-17 Novel d-glutamic acid derivative, its preparation, and immunizing agent containing said derivative as effective component

Country Status (1)

Country Link
JP (1) JPS56131554A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292722A (en) * 1992-11-06 1994-03-08 Brigham And Women's Hospital Intravenous solution that diminishes body protein loss
WO1994020454A1 (en) * 1993-03-10 1994-09-15 Rotta Research Laboratorium S.P.A. New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning
US5397803A (en) * 1985-09-12 1995-03-14 Brigham And Women's Hospital Use of glutamine to reduce rate of pathogenic microorganism infection
US5607975A (en) * 1985-09-12 1997-03-04 Brigham And Women's Hospital Method of treating catabolic, gut-associated pathological processes and impaired host defenses
US5763485A (en) * 1985-09-12 1998-06-09 Brigham And Women's Hospital Method of treating catabolic, gut-associated pathological processes and impaired host defenses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANGEWANDTE CHEMIE=1976 *
CHEMICAL AND PHARMACEUTICAL BULLETIN=1971 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5397803A (en) * 1985-09-12 1995-03-14 Brigham And Women's Hospital Use of glutamine to reduce rate of pathogenic microorganism infection
US5607975A (en) * 1985-09-12 1997-03-04 Brigham And Women's Hospital Method of treating catabolic, gut-associated pathological processes and impaired host defenses
US5684045A (en) * 1985-09-12 1997-11-04 Brigham And Women's Hospital Method of treating pancreatic atrophy
US5763485A (en) * 1985-09-12 1998-06-09 Brigham And Women's Hospital Method of treating catabolic, gut-associated pathological processes and impaired host defenses
US5292722A (en) * 1992-11-06 1994-03-08 Brigham And Women's Hospital Intravenous solution that diminishes body protein loss
WO1994020454A1 (en) * 1993-03-10 1994-09-15 Rotta Research Laboratorium S.P.A. New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning
AU685438B2 (en) * 1993-03-10 1998-01-22 Rottapharm S.P.A. New derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning

Also Published As

Publication number Publication date
JPS6338985B2 (en) 1988-08-03

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