JPS5785349A - Tripeptide alkylamide derivative - Google Patents
Tripeptide alkylamide derivativeInfo
- Publication number
- JPS5785349A JPS5785349A JP55161127A JP16112780A JPS5785349A JP S5785349 A JPS5785349 A JP S5785349A JP 55161127 A JP55161127 A JP 55161127A JP 16112780 A JP16112780 A JP 16112780A JP S5785349 A JPS5785349 A JP S5785349A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- protecting group
- afford
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 abstract 9
- 125000006239 protecting group Chemical group 0.000 abstract 3
- -1 L-Tyrosyl-D-methionine sulfoxide-glycyl-N-ethyl-L-phenylalaninol Chemical compound 0.000 abstract 1
- 102000003840 Opioid Receptors Human genes 0.000 abstract 1
- 108090000137 Opioid Receptors Proteins 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 230000001270 agonistic effect Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003193 general anesthetic agent Substances 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
NEW MATERIAL:A compound of formula I(R1 and R2 are H or lower alkyl; R3 and R4 are H acetyl).
EXAMPLE: L-Tyrosyl-D-methionine sulfoxide-glycyl-N-ethyl-L-phenylalaninol.
USE: An analgesic and anesthetic agent, having an agonistic activity in opiate receptors, and useful as an anesthetic antagonistic and antidiarrhetic agent with low toxicity and long duration.
PROCESS: A compound of formula II (A1 is protecting group of the amino group; A2 is OH, etc.) is condensed with a compound of the formula H-D-Met-OA3 (A3 is a protecting group of the carboxyl group) by the conventional peptide bond reacting to give a compound of formula III, which is then oxidized to afford a compound of formula IV. A compound of formula V obtained in the similar way is reacted with the compound of formula IV by the azide method to give a compound, and the protecting group of the resultant compound is then removed to afford the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55161127A JPS5785349A (en) | 1980-11-14 | 1980-11-14 | Tripeptide alkylamide derivative |
| PCT/JP1981/000175 WO1982000640A1 (en) | 1980-08-18 | 1981-08-13 | Tripeptide alkylamide derivatives |
| AU74557/81A AU7455781A (en) | 1980-08-18 | 1981-08-13 | Tripeptide alkylamide derivatives |
| IT05201/81A IT1205447B (en) | 1980-08-18 | 1981-08-17 | ALCHYLAMINE TRIPEPTIDE DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55161127A JPS5785349A (en) | 1980-11-14 | 1980-11-14 | Tripeptide alkylamide derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5785349A true JPS5785349A (en) | 1982-05-28 |
Family
ID=15729109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55161127A Pending JPS5785349A (en) | 1980-08-18 | 1980-11-14 | Tripeptide alkylamide derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5785349A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5459247A (en) * | 1977-10-03 | 1979-05-12 | Lilly Co Eli | Anodyne compound |
| JPS5738756A (en) * | 1980-08-18 | 1982-03-03 | Earth Chem Corp Ltd | Tripeptide alkylamide derivative |
-
1980
- 1980-11-14 JP JP55161127A patent/JPS5785349A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5459247A (en) * | 1977-10-03 | 1979-05-12 | Lilly Co Eli | Anodyne compound |
| JPS5738756A (en) * | 1980-08-18 | 1982-03-03 | Earth Chem Corp Ltd | Tripeptide alkylamide derivative |
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