JPS5649373A - N-((4-thiazolidinyl)carbonyl)amino acid derivative - Google Patents
N-((4-thiazolidinyl)carbonyl)amino acid derivativeInfo
- Publication number
- JPS5649373A JPS5649373A JP12622279A JP12622279A JPS5649373A JP S5649373 A JPS5649373 A JP S5649373A JP 12622279 A JP12622279 A JP 12622279A JP 12622279 A JP12622279 A JP 12622279A JP S5649373 A JPS5649373 A JP S5649373A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- compound
- formula
- thiazolidinyl
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:The titled compound of formula I (R is H, lower alkyl, etc.; R1 is H, R4CO-, etc.; R2 is H, lower alkyl, etc.; R3 is H, lower alkyl, phenyl, etc.; R4 is H, lower alkyl, lower alkenyl, etc.), and its salt.
EXAMPLE: N-[[ 3-( D-3-Benzoylthio- 2-methylpropanoyl )-L-4-thiazolidinyl ]carbonnyl]-L-phenylalanine.
USE: Antihypertensive agent having angiotensin I invertase inhibiting action. The development of the activity is milder than that of YS-980, and the activity lasts long.
PROCESS: The compound of formula I is prepared by reacting a compound of formula II or its reactive derivative at the carboxylic group with a compound of formula III in a solvent such as THF, CHCl3, etc. at -50W+60°C.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12622279A JPS5649373A (en) | 1979-09-28 | 1979-09-28 | N-((4-thiazolidinyl)carbonyl)amino acid derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12622279A JPS5649373A (en) | 1979-09-28 | 1979-09-28 | N-((4-thiazolidinyl)carbonyl)amino acid derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5649373A true JPS5649373A (en) | 1981-05-02 |
Family
ID=14929762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12622279A Pending JPS5649373A (en) | 1979-09-28 | 1979-09-28 | N-((4-thiazolidinyl)carbonyl)amino acid derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5649373A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998054207A1 (en) * | 1997-05-30 | 1998-12-03 | Celltech Therapeutics Limited | Anti-inflammatory tyrosine derivatives |
| WO1999035163A1 (en) * | 1998-01-08 | 1999-07-15 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| US6410576B1 (en) | 1998-07-28 | 2002-06-25 | Santen Pharmaceutical Co., Ltd. | Thiazolidine derivatives |
| US6953798B1 (en) | 1998-11-30 | 2005-10-11 | Celltech R&D Limited | β-alanine derivates |
-
1979
- 1979-09-28 JP JP12622279A patent/JPS5649373A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998054207A1 (en) * | 1997-05-30 | 1998-12-03 | Celltech Therapeutics Limited | Anti-inflammatory tyrosine derivatives |
| WO1999035163A1 (en) * | 1998-01-08 | 1999-07-15 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| US6410576B1 (en) | 1998-07-28 | 2002-06-25 | Santen Pharmaceutical Co., Ltd. | Thiazolidine derivatives |
| US6953798B1 (en) | 1998-11-30 | 2005-10-11 | Celltech R&D Limited | β-alanine derivates |
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