JPS56158753A - Kyotorphin derivative - Google Patents

Kyotorphin derivative

Info

Publication number
JPS56158753A
JPS56158753A JP6160180A JP6160180A JPS56158753A JP S56158753 A JPS56158753 A JP S56158753A JP 6160180 A JP6160180 A JP 6160180A JP 6160180 A JP6160180 A JP 6160180A JP S56158753 A JPS56158753 A JP S56158753A
Authority
JP
Japan
Prior art keywords
formula
derivative
dipeptide
protecting group
kyotorphin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6160180A
Other languages
Japanese (ja)
Other versions
JPS634531B2 (en
Inventor
Yoshiaki Kiso
Shizuo Nakamura
Kazuko Ukawa
Yukimi Kitagawa
Tadashi Akita
Hideki Moritoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP6160180A priority Critical patent/JPS56158753A/en
Publication of JPS56158753A publication Critical patent/JPS56158753A/en
Publication of JPS634531B2 publication Critical patent/JPS634531B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A kyotorphin derivative of formula I (R1 is H or lower alkyl; R2 is H or nitro) and a salt thereof.
EXAMPLE: L-Tyrosyl-L-argininol.
USE: An analgesic agent having an agonistic activity in an opiate acceptor and with low toxicity.
PROCESS: A tyrosine derivative of formula II (R3 is a protecting group of the amino group) is reacted with an arginine derivative of formula III (R4 is a protecting group of the carboxyl group) by the usual peptide linkage forming method, e.g. the condensation with DCC, to give a dipeptide of formula IV, which is then reduced with sodium boron hydride to afford a dipeptide of formula V. The protecting group (R3) is then removed from the resultant dipeptide of formula V to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP6160180A 1980-05-08 1980-05-08 Kyotorphin derivative Granted JPS56158753A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6160180A JPS56158753A (en) 1980-05-08 1980-05-08 Kyotorphin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6160180A JPS56158753A (en) 1980-05-08 1980-05-08 Kyotorphin derivative

Publications (2)

Publication Number Publication Date
JPS56158753A true JPS56158753A (en) 1981-12-07
JPS634531B2 JPS634531B2 (en) 1988-01-29

Family

ID=13175841

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6160180A Granted JPS56158753A (en) 1980-05-08 1980-05-08 Kyotorphin derivative

Country Status (1)

Country Link
JP (1) JPS56158753A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60116700A (en) * 1983-11-30 1985-06-24 Dai Ichi Seiyaku Co Ltd Kyotorphin derivative
EP0192135A2 (en) * 1985-02-18 1986-08-27 BEHRINGWERKE Aktiengesellschaft Oligopeptidylargininol derivatives and their homologues, process for their preparation, their use and agents containing them

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60116700A (en) * 1983-11-30 1985-06-24 Dai Ichi Seiyaku Co Ltd Kyotorphin derivative
JPH0446278B2 (en) * 1983-11-30 1992-07-29 Daiichi Seiyaku Co
EP0192135A2 (en) * 1985-02-18 1986-08-27 BEHRINGWERKE Aktiengesellschaft Oligopeptidylargininol derivatives and their homologues, process for their preparation, their use and agents containing them

Also Published As

Publication number Publication date
JPS634531B2 (en) 1988-01-29

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