JPS55167268A - Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester - Google Patents
Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl esterInfo
- Publication number
- JPS55167268A JPS55167268A JP7608279A JP7608279A JPS55167268A JP S55167268 A JPS55167268 A JP S55167268A JP 7608279 A JP7608279 A JP 7608279A JP 7608279 A JP7608279 A JP 7608279A JP S55167268 A JPS55167268 A JP S55167268A
- Authority
- JP
- Japan
- Prior art keywords
- aspartyl
- lower alkyl
- alkyl ester
- crystal
- phenylalanine lower
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To purify the titled compound useful as a low-caloric sweetening agent, by bringing a purified crystal of an α-L-aspartyl-L-phenylalanine lower alkyl ester into contact with a specific aqueous medium.
CONSTITUTION: A crystal of an α-L-aspartyl-L-phenylalanine lower alkyl ester (α-APE) containing at least 3-benzyl-6-carboxymethyl-2,5-diketopiperazine (DKP) as an impurity is brought into contact with an aqueous medium, e.g. water or its mixture with an organic solvent homogeneously miscible with water, of pH 4.5W8 for a time enough to elute the substantial part of DKP in the crystal, e.g. 20min or longer, and purified. In case the medium has no buffering ability, the pH may be readjusted by adding a basic substance, e.g. NaOH, thereto. The amount of the medium is 5W40 times that of α-APE.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7608279A JPS55167268A (en) | 1979-06-16 | 1979-06-16 | Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7608279A JPS55167268A (en) | 1979-06-16 | 1979-06-16 | Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55167268A true JPS55167268A (en) | 1980-12-26 |
JPS6112919B2 JPS6112919B2 (en) | 1986-04-10 |
Family
ID=13594894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7608279A Granted JPS55167268A (en) | 1979-06-16 | 1979-06-16 | Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55167268A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4900863A (en) * | 1986-10-20 | 1990-02-13 | Hoechst Aktiengesellschaft | Process for the purification of N-acylaspartame |
US5041607A (en) * | 1982-04-12 | 1991-08-20 | Ajinomoto Co., Inc. | Process for crystallizing L-alpha-aspartyl-L-phenyl-alanine methyl |
WO1992000953A1 (en) * | 1988-02-12 | 1992-01-23 | The Nutrasweet Company | A one-pot process for the preparation of alpha-l-aspartyl-l-phenylalanine methyl ester hydrochloride |
-
1979
- 1979-06-16 JP JP7608279A patent/JPS55167268A/en active Granted
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5041607A (en) * | 1982-04-12 | 1991-08-20 | Ajinomoto Co., Inc. | Process for crystallizing L-alpha-aspartyl-L-phenyl-alanine methyl |
US5097060A (en) * | 1982-04-12 | 1992-03-17 | Ajinomoto Company Incorporated | Process for crystallizing l-alpha-aspartyl-l-phenyl-alanine methyl ester |
US5621137A (en) * | 1982-04-12 | 1997-04-15 | Ajinomoto Co., Inc. | Method of dissolving crystals of L-α-aspartyl-L-phenylalanine methyl ester |
US5744632A (en) * | 1982-04-12 | 1998-04-28 | Ajinomoto Company Incorporated | Process for crystallizing L-α-aspartyl-L-phenylalanine methyl ester |
US4900863A (en) * | 1986-10-20 | 1990-02-13 | Hoechst Aktiengesellschaft | Process for the purification of N-acylaspartame |
WO1992000953A1 (en) * | 1988-02-12 | 1992-01-23 | The Nutrasweet Company | A one-pot process for the preparation of alpha-l-aspartyl-l-phenylalanine methyl ester hydrochloride |
Also Published As
Publication number | Publication date |
---|---|
JPS6112919B2 (en) | 1986-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR830007671A (en) | Process for the preparation of crystalline 1,1-dioxophenicilanoyloxymethyl 6- (D-α-amino-α-phenylacetamido) phenylanate tosylate hydrate | |
JPS55167268A (en) | Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester | |
JPS55136257A (en) | Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester | |
JPS5646850A (en) | Method for reductive elimination of protecting group | |
JPS5334716A (en) | Preparation of amide amine amphoteric surface active agent | |
JPS5699498A (en) | Rreparation of alpha-glycosyl steviol glycoside | |
JPS5245585A (en) | Method of stabilizing properties of crystal in flue gas desulfurizatio n process | |
JPS5323916A (en) | Preparation of thioglycosides | |
JPS5231021A (en) | Process for purification of crude n-omega-long-chain acyl basic amino acid or its metal salt | |
JPS53113080A (en) | Purification of urokinase | |
JPS5212984A (en) | Purification of urokinase | |
JPS5251305A (en) | Proces for purification of isoprene | |
JPS5382718A (en) | Purification of decance-1,10-dicarboxylic acid or its ester | |
JPS57140785A (en) | Benzothiazine derivative, its preparation, and pharmaceutical composition containing the same | |
JPS5430200A (en) | Purification of stevioside | |
JPS5382717A (en) | Purification of sebacic acid or its ester | |
JPS52130988A (en) | Preparation of l-sulfur-containing amino acids | |
JPS57192348A (en) | Decaprenyl-substituted amino acid derivative | |
CA2310761A1 (en) | Sweetener compositions containing aspartame and aspartame derivative | |
JPS5318521A (en) | Preparation of 3,5-dichloronitrogenzene | |
JPS5687579A (en) | Novel eliminating agent and its preparation | |
JPS5671080A (en) | Novel mandelic tetrazol-5-ylthiol ester and its preparation | |
JPS52102298A (en) | Recovery and purification of 3#,5#-cyclic adenilic acid | |
JPS5758694A (en) | Monobenzylphosphorylalanylproline and hypotensive comprising it | |
JPS56164197A (en) | Novel aminoglycoside |