JPS55167268A - Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester - Google Patents

Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester

Info

Publication number
JPS55167268A
JPS55167268A JP7608279A JP7608279A JPS55167268A JP S55167268 A JPS55167268 A JP S55167268A JP 7608279 A JP7608279 A JP 7608279A JP 7608279 A JP7608279 A JP 7608279A JP S55167268 A JPS55167268 A JP S55167268A
Authority
JP
Japan
Prior art keywords
aspartyl
lower alkyl
alkyl ester
crystal
phenylalanine lower
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7608279A
Other languages
Japanese (ja)
Other versions
JPS6112919B2 (en
Inventor
Kiyotaka Koyama
Mikio Ito
Masaji Kubo
Yuji Nonaka
Masao Nakamura
Masayoshi Naruse
Tetsuo Yamatani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Sagami Chemical Research Institute
Tosoh Corp
Original Assignee
Ajinomoto Co Inc
Sagami Chemical Research Institute
Toyo Soda Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc, Sagami Chemical Research Institute, Toyo Soda Manufacturing Co Ltd filed Critical Ajinomoto Co Inc
Priority to JP7608279A priority Critical patent/JPS55167268A/en
Publication of JPS55167268A publication Critical patent/JPS55167268A/en
Publication of JPS6112919B2 publication Critical patent/JPS6112919B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To purify the titled compound useful as a low-caloric sweetening agent, by bringing a purified crystal of an α-L-aspartyl-L-phenylalanine lower alkyl ester into contact with a specific aqueous medium.
CONSTITUTION: A crystal of an α-L-aspartyl-L-phenylalanine lower alkyl ester (α-APE) containing at least 3-benzyl-6-carboxymethyl-2,5-diketopiperazine (DKP) as an impurity is brought into contact with an aqueous medium, e.g. water or its mixture with an organic solvent homogeneously miscible with water, of pH 4.5W8 for a time enough to elute the substantial part of DKP in the crystal, e.g. 20min or longer, and purified. In case the medium has no buffering ability, the pH may be readjusted by adding a basic substance, e.g. NaOH, thereto. The amount of the medium is 5W40 times that of α-APE.
COPYRIGHT: (C)1980,JPO&Japio
JP7608279A 1979-06-16 1979-06-16 Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester Granted JPS55167268A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7608279A JPS55167268A (en) 1979-06-16 1979-06-16 Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7608279A JPS55167268A (en) 1979-06-16 1979-06-16 Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester

Publications (2)

Publication Number Publication Date
JPS55167268A true JPS55167268A (en) 1980-12-26
JPS6112919B2 JPS6112919B2 (en) 1986-04-10

Family

ID=13594894

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7608279A Granted JPS55167268A (en) 1979-06-16 1979-06-16 Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester

Country Status (1)

Country Link
JP (1) JPS55167268A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900863A (en) * 1986-10-20 1990-02-13 Hoechst Aktiengesellschaft Process for the purification of N-acylaspartame
US5041607A (en) * 1982-04-12 1991-08-20 Ajinomoto Co., Inc. Process for crystallizing L-alpha-aspartyl-L-phenyl-alanine methyl
WO1992000953A1 (en) * 1988-02-12 1992-01-23 The Nutrasweet Company A one-pot process for the preparation of alpha-l-aspartyl-l-phenylalanine methyl ester hydrochloride

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041607A (en) * 1982-04-12 1991-08-20 Ajinomoto Co., Inc. Process for crystallizing L-alpha-aspartyl-L-phenyl-alanine methyl
US5097060A (en) * 1982-04-12 1992-03-17 Ajinomoto Company Incorporated Process for crystallizing l-alpha-aspartyl-l-phenyl-alanine methyl ester
US5621137A (en) * 1982-04-12 1997-04-15 Ajinomoto Co., Inc. Method of dissolving crystals of L-α-aspartyl-L-phenylalanine methyl ester
US5744632A (en) * 1982-04-12 1998-04-28 Ajinomoto Company Incorporated Process for crystallizing L-α-aspartyl-L-phenylalanine methyl ester
US4900863A (en) * 1986-10-20 1990-02-13 Hoechst Aktiengesellschaft Process for the purification of N-acylaspartame
WO1992000953A1 (en) * 1988-02-12 1992-01-23 The Nutrasweet Company A one-pot process for the preparation of alpha-l-aspartyl-l-phenylalanine methyl ester hydrochloride

Also Published As

Publication number Publication date
JPS6112919B2 (en) 1986-04-10

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