JPS5731648A - Pentapeptide derivative - Google Patents

Pentapeptide derivative

Info

Publication number
JPS5731648A
JPS5731648A JP10527180A JP10527180A JPS5731648A JP S5731648 A JPS5731648 A JP S5731648A JP 10527180 A JP10527180 A JP 10527180A JP 10527180 A JP10527180 A JP 10527180A JP S5731648 A JPS5731648 A JP S5731648A
Authority
JP
Japan
Prior art keywords
methylphenylalanyl
leucinol
tyrosyl
arginyl
glycine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10527180A
Other languages
Japanese (ja)
Other versions
JPS6334880B2 (en
Inventor
Hiroshi Takagi
Haruaki Yajima
Osamu Nagase
Minoru Kubota
Hiroshi Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP10527180A priority Critical patent/JPS5731648A/en
Publication of JPS5731648A publication Critical patent/JPS5731648A/en
Publication of JPS6334880B2 publication Critical patent/JPS6334880B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:The compound of formula [R1 and R2 are H or methyl; R3 is -CH2CH(CH3)2, -CH2CH2SCH3, etc.; X is L(D)-arginine; Tyr is tyrosine; Gly is glycine].
EXAMPLE: Tyrosyl-D-arginyl-glycyl-N-methylphenylalanyl-leucinol.
USE: Long-acting analgesic.
PROCESS: For example, benzyloxycarbonyl-tyrosyl-D-arginyl-mesitylene-2-sulfonyl- hydrazide, etc. are dissolved in DMF, etc., and added with hydrochloric acid, isoamyl nitrite, etc. under cooling. The mixture is made to react with glycine, etc. in the presence of an alkali, mixed with DMF solution of N-methylphenylalanyl- leucinol, etc., cooled, and made to react with triethylamine, 1-hydroxybenzotriazole, and dicyclohexylcarbodiimide by adding the compound in the order.
COPYRIGHT: (C)1982,JPO&Japio
JP10527180A 1980-07-31 1980-07-31 Pentapeptide derivative Granted JPS5731648A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10527180A JPS5731648A (en) 1980-07-31 1980-07-31 Pentapeptide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10527180A JPS5731648A (en) 1980-07-31 1980-07-31 Pentapeptide derivative

Publications (2)

Publication Number Publication Date
JPS5731648A true JPS5731648A (en) 1982-02-20
JPS6334880B2 JPS6334880B2 (en) 1988-07-12

Family

ID=14402994

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10527180A Granted JPS5731648A (en) 1980-07-31 1980-07-31 Pentapeptide derivative

Country Status (1)

Country Link
JP (1) JPS5731648A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60240111A (en) * 1984-05-07 1985-11-29 ウエスチングハウス　エレクトリック　コ−ポレ−ション Transformer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60240111A (en) * 1984-05-07 1985-11-29 ウエスチングハウス　エレクトリック　コ−ポレ−ション Transformer

Also Published As

Publication number Publication date
JPS6334880B2 (en) 1988-07-12

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