JPS5630956A - Gamma-l-glutamyl-p-aminoanilide derivative or its salt and determination of gamma-glutamyl transferase using the same - Google Patents

Gamma-l-glutamyl-p-aminoanilide derivative or its salt and determination of gamma-glutamyl transferase using the same

Info

Publication number
JPS5630956A
JPS5630956A JP10737679A JP10737679A JPS5630956A JP S5630956 A JPS5630956 A JP S5630956A JP 10737679 A JP10737679 A JP 10737679A JP 10737679 A JP10737679 A JP 10737679A JP S5630956 A JPS5630956 A JP S5630956A
Authority
JP
Japan
Prior art keywords
glutamyl
gamma
salt
derivative
determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10737679A
Other languages
Japanese (ja)
Other versions
JPS631939B2 (en
Inventor
Yoshinobu Miyashita
Kenji Iwata
Hitoshi Uemori
Hisahiko Shimada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Wako Pure Chemical Corp
Original Assignee
Wako Pure Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wako Pure Chemical Industries Ltd filed Critical Wako Pure Chemical Industries Ltd
Priority to JP10737679A priority Critical patent/JPS5630956A/en
Publication of JPS5630956A publication Critical patent/JPS5630956A/en
Publication of JPS631939B2 publication Critical patent/JPS631939B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:The titled compound of formula I (A is lower alkylene; R is lower alkyl) or its salt.
EXAMPLE: γ-L-glutamyl-p-(N-ethyl-N-hydroxyethylamino)anilide.
USE: Useful as a substrate for determination of γ-GTP, an important enzyme for examination of the liver function. Highly reactive to γ-GTP, highly soluble and able to be determined by light having long wavelength.
PROCESS: N-protected-γ-L-glutamic acid anhydride (e.g. N-phthalyl-γ-L-glutamic acid anhydride) and a derivative of p-phenylenediamine of formula II are made to react in a solvent (e.g. chloroform, dichloroethane, etc.) at 20W100°C to give a derivative of N-protected-γ-L-glutamyl-p-aminoanilide. The protecting group of the product is then removed to afford a compound of formula I or its salt.
COPYRIGHT: (C)1981,JPO&Japio
JP10737679A 1979-08-23 1979-08-23 Gamma-l-glutamyl-p-aminoanilide derivative or its salt and determination of gamma-glutamyl transferase using the same Granted JPS5630956A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10737679A JPS5630956A (en) 1979-08-23 1979-08-23 Gamma-l-glutamyl-p-aminoanilide derivative or its salt and determination of gamma-glutamyl transferase using the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10737679A JPS5630956A (en) 1979-08-23 1979-08-23 Gamma-l-glutamyl-p-aminoanilide derivative or its salt and determination of gamma-glutamyl transferase using the same

Publications (2)

Publication Number Publication Date
JPS5630956A true JPS5630956A (en) 1981-03-28
JPS631939B2 JPS631939B2 (en) 1988-01-14

Family

ID=14457529

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10737679A Granted JPS5630956A (en) 1979-08-23 1979-08-23 Gamma-l-glutamyl-p-aminoanilide derivative or its salt and determination of gamma-glutamyl transferase using the same

Country Status (1)

Country Link
JP (1) JPS5630956A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01129768U (en) * 1988-02-26 1989-09-04
WO1991012232A1 (en) * 1990-02-06 1991-08-22 Australian Commercial Research & Development Limited Compounds and methods for the treatment and diagnosis of cancer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01129768U (en) * 1988-02-26 1989-09-04
WO1991012232A1 (en) * 1990-02-06 1991-08-22 Australian Commercial Research & Development Limited Compounds and methods for the treatment and diagnosis of cancer

Also Published As

Publication number Publication date
JPS631939B2 (en) 1988-01-14

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