JPS5690050A - Novel threo-3-amino-2-hydroxybutanoylaminoacetic acid - Google Patents

Novel threo-3-amino-2-hydroxybutanoylaminoacetic acid

Info

Publication number
JPS5690050A
JPS5690050A JP14948579A JP14948579A JPS5690050A JP S5690050 A JPS5690050 A JP S5690050A JP 14948579 A JP14948579 A JP 14948579A JP 14948579 A JP14948579 A JP 14948579A JP S5690050 A JPS5690050 A JP S5690050A
Authority
JP
Japan
Prior art keywords
formula
compound
amino
group
hydroxybutanoylaminoacetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14948579A
Other languages
Japanese (ja)
Other versions
JPS6223743B2 (en
Inventor
Hamao Umezawa
Takaaki Aoyanagi
Tadashi Shirai
Rinzo Nishizawa
Masao Suzuki
Tetsuyuki Saino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP14948579A priority Critical patent/JPS5690050A/en
Publication of JPS5690050A publication Critical patent/JPS5690050A/en
Publication of JPS6223743B2 publication Critical patent/JPS6223743B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The titled compound of formula I [R1 is naphthyl or group of formula II (R6 and R7 are H, F, OH, lower alkoxyl, etc.; when one of R6 and R7 is H or OH, the other is group other than H); R4 is 3W4C alkyl or 3-guanidinopropyl].
EXAMPLE: (2S,3R)-3-Amino-2-hydroxy-4-(4'-methoxyphenyl)butanoyl-(S)-leucine.
USE: A medicine capable of inhibiting aminopeptidase B in the same manner as Bestatin [chemical name: (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-S- leucine] having an immunological enhancing action and a cancer inhibitory effect.
PROCESS: The reaction product between a compound of formula III (R2 is protected amino group) and a compound of formula IV (R3 is H or ester residue) is reduced by the catalytic reduction, and the resultant product is condensed with a compound of formula V. The protecting group is then removed to afford the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP14948579A 1979-11-20 1979-11-20 Novel threo-3-amino-2-hydroxybutanoylaminoacetic acid Granted JPS5690050A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14948579A JPS5690050A (en) 1979-11-20 1979-11-20 Novel threo-3-amino-2-hydroxybutanoylaminoacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14948579A JPS5690050A (en) 1979-11-20 1979-11-20 Novel threo-3-amino-2-hydroxybutanoylaminoacetic acid

Publications (2)

Publication Number Publication Date
JPS5690050A true JPS5690050A (en) 1981-07-21
JPS6223743B2 JPS6223743B2 (en) 1987-05-25

Family

ID=15476176

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14948579A Granted JPS5690050A (en) 1979-11-20 1979-11-20 Novel threo-3-amino-2-hydroxybutanoylaminoacetic acid

Country Status (1)

Country Link
JP (1) JPS5690050A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007029587A1 (en) 2005-09-05 2007-03-15 Dainippon Sumitomo Pharma Co., Ltd. β SECRETASE INHIBITOR
JP2019520369A (en) * 2016-07-05 2019-07-18 ノバルティス アーゲー Novel Method for Early Sacvitril Intermediates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007029587A1 (en) 2005-09-05 2007-03-15 Dainippon Sumitomo Pharma Co., Ltd. β SECRETASE INHIBITOR
JP2019520369A (en) * 2016-07-05 2019-07-18 ノバルティス アーゲー Novel Method for Early Sacvitril Intermediates

Also Published As

Publication number Publication date
JPS6223743B2 (en) 1987-05-25

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