JPS5519228A - 6-c substituted purine nucleoside and its preparation - Google Patents
6-c substituted purine nucleoside and its preparationInfo
- Publication number
- JPS5519228A JPS5519228A JP9158178A JP9158178A JPS5519228A JP S5519228 A JPS5519228 A JP S5519228A JP 9158178 A JP9158178 A JP 9158178A JP 9158178 A JP9158178 A JP 9158178A JP S5519228 A JPS5519228 A JP S5519228A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- purine nucleoside
- substituted purine
- preparation
- antitumoregenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
NEW MATERIAL:6-C substituted purine nucleoside of formula I (R is cyano, formula II ; R1, R2 are H, nitro, cyano, alkylcarbonyl, where the case when both are hydrogens at the same time is excluded; Y, Z are H, protecting group).
EXAMPLE: 9-β-D-Ribofuranosyl-6-ethoxycarbonylmethlpurine.
USE: Drug having antitumoregenic, adenylaminase inhibiting activities and synthetic of 6-C substituted purine nucleoside as 9-β- D-ribofuranosyl-6-methylpurine that has strong antitumoregenic and adenyldeaminase inhibiting activities.
PREPARATION: The reaction between 6-methylsulfonylpurine nucleoside of formula III and a compound of formula IV (R3, R4 are H, nitro; however, the case when they are both H at the same time are excluded) in the presence of cyanide ion or a base is effected to produce the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9158178A JPS5519228A (en) | 1978-07-28 | 1978-07-28 | 6-c substituted purine nucleoside and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9158178A JPS5519228A (en) | 1978-07-28 | 1978-07-28 | 6-c substituted purine nucleoside and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5519228A true JPS5519228A (en) | 1980-02-09 |
| JPS5728718B2 JPS5728718B2 (en) | 1982-06-18 |
Family
ID=14030502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9158178A Granted JPS5519228A (en) | 1978-07-28 | 1978-07-28 | 6-c substituted purine nucleoside and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5519228A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5533434A (en) * | 1978-09-01 | 1980-03-08 | Yamasa Shoyu Co Ltd | Production of 6-dicyanomethylpurine nucleoside |
-
1978
- 1978-07-28 JP JP9158178A patent/JPS5519228A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5533434A (en) * | 1978-09-01 | 1980-03-08 | Yamasa Shoyu Co Ltd | Production of 6-dicyanomethylpurine nucleoside |
| JPS5842197B2 (en) * | 1978-09-01 | 1983-09-17 | ヤマサ醤油株式会社 | 6↓-Method for producing dicyanomethylpurine nucleoside |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5728718B2 (en) | 1982-06-18 |
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