JPS565456A - Prostacycline derivative - Google Patents

Prostacycline derivative

Info

Publication number
JPS565456A
JPS565456A JP8087079A JP8087079A JPS565456A JP S565456 A JPS565456 A JP S565456A JP 8087079 A JP8087079 A JP 8087079A JP 8087079 A JP8087079 A JP 8087079A JP S565456 A JPS565456 A JP S565456A
Authority
JP
Japan
Prior art keywords
alkyl
formula
prostacycline
compound shown
pge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8087079A
Other languages
Japanese (ja)
Other versions
JPS6340175B2 (en
Inventor
Koichi Kojima
Kiyoshi Sakai
Shinsaku Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP8087079A priority Critical patent/JPS565456A/en
Publication of JPS565456A publication Critical patent/JPS565456A/en
Publication of JPS6340175B2 publication Critical patent/JPS6340175B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A prostacycline derivative shown by the formula I (R1 is alkyl or alkenyl; R2 is alkyl or ethynyl; or both R1 and R2 are H; m is integer of 0W5; n is integer of 0W3; Y is direct bond, trans-vinylene, etc.) its salt, and its alkyl ester.
EXAMPLE: 5,8α-Methylene-10α,14-dihydroxy-14-methylnorprost-4,12(E)-dienoic acid.
USE: A blood platelet coagulation inhibitor. Having almost the same activity as that of PGE1(prostaglandine E1), but stabler than PGE1 and PGI2(prostacycline I2).
PROCESS: A compound shown by the formula II (R1' is alkyl, etc.) is oxidized with DDQ(dichlorodycianobenzoquinone), etc. to give a compound shown by the formula III. COOH or OH group of the compound is protected, if necessary. It is alkylated by a Grignard reagent, or subjected to ethynylation, and, the protecting group is removed, to give the compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP8087079A 1979-06-27 1979-06-27 Prostacycline derivative Granted JPS565456A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8087079A JPS565456A (en) 1979-06-27 1979-06-27 Prostacycline derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8087079A JPS565456A (en) 1979-06-27 1979-06-27 Prostacycline derivative

Publications (2)

Publication Number Publication Date
JPS565456A true JPS565456A (en) 1981-01-20
JPS6340175B2 JPS6340175B2 (en) 1988-08-10

Family

ID=13730370

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8087079A Granted JPS565456A (en) 1979-06-27 1979-06-27 Prostacycline derivative

Country Status (1)

Country Link
JP (1) JPS565456A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60206882A (en) * 1984-03-30 1985-10-18 Sunstar Giken Kk Epoxy resin adhesive
JPS60235877A (en) * 1984-05-08 1985-11-22 Sunstar Giken Kk Epoxy resin adhesive for automobile

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100193572B1 (en) * 1995-06-30 1999-06-15 이형도 Breathless DC Motor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60206882A (en) * 1984-03-30 1985-10-18 Sunstar Giken Kk Epoxy resin adhesive
JPS60235877A (en) * 1984-05-08 1985-11-22 Sunstar Giken Kk Epoxy resin adhesive for automobile
JPH0349692B2 (en) * 1984-05-08 1991-07-30 Sunstar Engineering Inc

Also Published As

Publication number Publication date
JPS6340175B2 (en) 1988-08-10

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