JPS5795980A - 7-hydroxy pgi2 and its preparation - Google Patents

7-hydroxy pgi2 and its preparation

Info

Publication number
JPS5795980A
JPS5795980A JP55172543A JP17254380A JPS5795980A JP S5795980 A JPS5795980 A JP S5795980A JP 55172543 A JP55172543 A JP 55172543A JP 17254380 A JP17254380 A JP 17254380A JP S5795980 A JPS5795980 A JP S5795980A
Authority
JP
Japan
Prior art keywords
configuration
compound
pgi
hydroxy
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55172543A
Other languages
Japanese (ja)
Other versions
JPH026755B2 (en
Inventor
Kiyoshi Sakauchi
Takeshi Yu
Takeo Oba
Toshio Tanaka
Noriaki Okamura
Kenzo Watanabe
Seiji Kurozumi
Akira Otsu
Tatsuyuki Naritomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP55172543A priority Critical patent/JPS5795980A/en
Priority to DE8181110156T priority patent/DE3176313D1/en
Priority to EP81110156A priority patent/EP0054795B1/en
Priority to US06/327,741 priority patent/US4472428A/en
Publication of JPS5795980A publication Critical patent/JPS5795980A/en
Publication of JPH026755B2 publication Critical patent/JPH026755B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 7-hydroxy PGI2 shown by the formula I(R1 is H, or 1W10C alkyl; K2 and R3 are H or OH-protecting group) or its acid addition salt where R1 is H.
EXAMPLE: 7-Hydroxyl-PGI2 methyl ester 11, 15-bis t-butyldimethyl-silyl ether.
USE: A hypotensor and an inhibitor for blood platelet aggregation, having improved stability and action selectivity as a drug of PGI2.
PROCESS: A compound shown by the formula II(R" is 1W10C alkyl) wherein preferably a steric configuration of 5-position is (R)-configuration, Δ6-double bond is (Z)-configuration, and a steric configuration of 7-position is (S) configuration is treated with a sulfurphilic compound, preferably an amine or a phosphorous type compound, and, if necessary, the resulting compound is subjected to a protective group removing reaction, a salt-forming reaction and/or a protecting reaction, to give a compound shown by the formulaIor a pharmaceutically acceptable salt of its acid.
COPYRIGHT: (C)1982,JPO&Japio
JP55172543A 1980-12-09 1980-12-09 7-hydroxy pgi2 and its preparation Granted JPS5795980A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP55172543A JPS5795980A (en) 1980-12-09 1980-12-09 7-hydroxy pgi2 and its preparation
DE8181110156T DE3176313D1 (en) 1980-12-09 1981-12-04 Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof
EP81110156A EP0054795B1 (en) 1980-12-09 1981-12-04 Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof
US06/327,741 US4472428A (en) 1980-12-09 1981-12-04 Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55172543A JPS5795980A (en) 1980-12-09 1980-12-09 7-hydroxy pgi2 and its preparation

Publications (2)

Publication Number Publication Date
JPS5795980A true JPS5795980A (en) 1982-06-15
JPH026755B2 JPH026755B2 (en) 1990-02-13

Family

ID=15943829

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55172543A Granted JPS5795980A (en) 1980-12-09 1980-12-09 7-hydroxy pgi2 and its preparation

Country Status (1)

Country Link
JP (1) JPS5795980A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112979600A (en) * 2021-03-01 2021-06-18 厦门大学 Split-ring acyl phloroglucinol compounds and application thereof in preparation of anti-cancer drugs

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55121210A (en) * 1979-03-13 1980-09-18 Matsushita Electric Ind Co Ltd Nonncombustible inorganic coating material for electronic part
JPS5799580A (en) * 1980-10-27 1982-06-21 Chinoin Gyogyszer Es Vegyeszet 7-substituted pgi2 derivative and manufacture

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55121210A (en) * 1979-03-13 1980-09-18 Matsushita Electric Ind Co Ltd Nonncombustible inorganic coating material for electronic part
JPS5799580A (en) * 1980-10-27 1982-06-21 Chinoin Gyogyszer Es Vegyeszet 7-substituted pgi2 derivative and manufacture

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112979600A (en) * 2021-03-01 2021-06-18 厦门大学 Split-ring acyl phloroglucinol compounds and application thereof in preparation of anti-cancer drugs

Also Published As

Publication number Publication date
JPH026755B2 (en) 1990-02-13

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