JPS56120680A - Prostaglandin i2 derivative - Google Patents

Prostaglandin i2 derivative

Info

Publication number
JPS56120680A
JPS56120680A JP2227280A JP2227280A JPS56120680A JP S56120680 A JPS56120680 A JP S56120680A JP 2227280 A JP2227280 A JP 2227280A JP 2227280 A JP2227280 A JP 2227280A JP S56120680 A JPS56120680 A JP S56120680A
Authority
JP
Japan
Prior art keywords
formula
prostaglandin
compound
agent
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2227280A
Other languages
Japanese (ja)
Other versions
JPH0122273B2 (en
Inventor
Kiyotaka Ono
Hiroshi Nagase
Shintaro Nishio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP2227280A priority Critical patent/JPS56120680A/en
Publication of JPS56120680A publication Critical patent/JPS56120680A/en
Publication of JPH0122273B2 publication Critical patent/JPH0122273B2/ja
Granted legal-status Critical Current

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  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A prostaglandin I2 derivative of formula I [R is group of formula II which may have a methyl group in the pyridine ring, group of formula III, formula IV, or -(CH2CH2O)2OR4; R1 is 1W3C alkylene; R3 is 1W29C alkyl; R4 is 1W12C alkyl].
EXAMPLE: Prostaglandin I2-2-pyridylmethyl ester.
USE: Remedies such as antithrombic agent, antiulcer agent, antihypertension agent, etc., having improved stability under neutral or acidic conditions, keeping the strong pharmacological activity of the prostaglandin I2. It can be orally administered.
PROCESS: The compound of formula I is prepared by (1) esterifying the compound of formula V, (2) reacting the product with a halogenating reagent thereby effecting intramolecular cyclization, and (3) reacting the resulting compound of formula VI (X is Br or I) with various bases to effect dehydrohalogenation reaction.
COPYRIGHT: (C)1981,JPO&Japio
JP2227280A 1980-02-26 1980-02-26 Prostaglandin i2 derivative Granted JPS56120680A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2227280A JPS56120680A (en) 1980-02-26 1980-02-26 Prostaglandin i2 derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2227280A JPS56120680A (en) 1980-02-26 1980-02-26 Prostaglandin i2 derivative

Publications (2)

Publication Number Publication Date
JPS56120680A true JPS56120680A (en) 1981-09-22
JPH0122273B2 JPH0122273B2 (en) 1989-04-25

Family

ID=12078120

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2227280A Granted JPS56120680A (en) 1980-02-26 1980-02-26 Prostaglandin i2 derivative

Country Status (1)

Country Link
JP (1) JPS56120680A (en)

Also Published As

Publication number Publication date
JPH0122273B2 (en) 1989-04-25

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