JPS55153782A - Dibenzo (b,f) thiepin derivative - Google Patents
Dibenzo (b,f) thiepin derivativeInfo
- Publication number
- JPS55153782A JPS55153782A JP6089379A JP6089379A JPS55153782A JP S55153782 A JPS55153782 A JP S55153782A JP 6089379 A JP6089379 A JP 6089379A JP 6089379 A JP6089379 A JP 6089379A JP S55153782 A JPS55153782 A JP S55153782A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- thiepin
- dibenzo
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A dibenzo [b, f] thiepin derivative of formula I [R is H or 2-(2- hydroxyethoxy)ethyl group].
EXAMPLE: 2-(8-Methyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin-2-yl)propionic acid.
USE: An anti-inflammatory, analgesic, and antipyretic agent having a powerful pharmacological effect and remarkably improved safety.
PROCESS: A novel compound of formula II is cyclized by the well-known method to give the compound of formula I (R is H). The resulting compound or its reactive derivative is esterified with a compound of formula III (X is halogen of atomic number ≥17) by the conventional method to form the compound of formula I [R is 2-(2-hydroxyethoxy)ethyl group]. The compound of formula II can be prepared from the compounds of formulas IV and V (R' is 1W6C alkyl group).
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6089379A JPS55153782A (en) | 1979-05-17 | 1979-05-17 | Dibenzo (b,f) thiepin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6089379A JPS55153782A (en) | 1979-05-17 | 1979-05-17 | Dibenzo (b,f) thiepin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55153782A true JPS55153782A (en) | 1980-11-29 |
JPS6245869B2 JPS6245869B2 (en) | 1987-09-29 |
Family
ID=13155483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6089379A Granted JPS55153782A (en) | 1979-05-17 | 1979-05-17 | Dibenzo (b,f) thiepin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55153782A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57106678A (en) * | 1980-12-23 | 1982-07-02 | Nippon Chemiphar Co Ltd | Preparation of dibenzothiepinpropionic acid derivative |
WO2008096755A1 (en) * | 2007-02-07 | 2008-08-14 | Nippon Suisan Kaisha, Ltd. | Vanilloid receptor (vr1) inhibitor and use thereof |
-
1979
- 1979-05-17 JP JP6089379A patent/JPS55153782A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57106678A (en) * | 1980-12-23 | 1982-07-02 | Nippon Chemiphar Co Ltd | Preparation of dibenzothiepinpropionic acid derivative |
JPH0129793B2 (en) * | 1980-12-23 | 1989-06-14 | Nippon Chemiphar Co | |
WO2008096755A1 (en) * | 2007-02-07 | 2008-08-14 | Nippon Suisan Kaisha, Ltd. | Vanilloid receptor (vr1) inhibitor and use thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS6245869B2 (en) | 1987-09-29 |
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