JPS55122784A - Novel acetic acid derivative and its preparation - Google Patents

Novel acetic acid derivative and its preparation

Info

Publication number
JPS55122784A
JPS55122784A JP2999579A JP2999579A JPS55122784A JP S55122784 A JPS55122784 A JP S55122784A JP 2999579 A JP2999579 A JP 2999579A JP 2999579 A JP2999579 A JP 2999579A JP S55122784 A JPS55122784 A JP S55122784A
Authority
JP
Japan
Prior art keywords
acetic acid
compound
acid derivative
reducing
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2999579A
Other languages
Japanese (ja)
Other versions
JPS6347714B2 (en
Inventor
Shigeru Yamabe
Yasuo Fujimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP2999579A priority Critical patent/JPS55122784A/en
Publication of JPS55122784A publication Critical patent/JPS55122784A/en
Publication of JPS6347714B2 publication Critical patent/JPS6347714B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An acetic acid derivative of formula I (A is O or S).
EXAMPLE: (5,6-Dihydro-6-hydroxybenzo[b]pyrido[3,2-f]thiepin-8-yl)-acetic acid.
USE: Antiphlogistic agent effective at a lower dose than conventional antiphlogistics.
PROCESS: The compound I is prepared by reducing the compound II with a reducing agent such as sodium borohydride in an ether. The compound II can be prepared e.g. by (1) reacting 2-halogeno-3-pyridylacetic acid ester with p-mercapto- (or hydroxy-)benzaldehyde, (2) reducing, halogenating and cyanating the reaction product, (3) removing the ester residue by hydrolysis, (4) closing the ring of the resulting 2-(4-cyanomethylphenylthio-) (or phenyxy-)3-pyridylacetic acid, and (5) hydrolyzing the product.
COPYRIGHT: (C)1980,JPO&Japio
JP2999579A 1979-03-16 1979-03-16 Novel acetic acid derivative and its preparation Granted JPS55122784A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2999579A JPS55122784A (en) 1979-03-16 1979-03-16 Novel acetic acid derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2999579A JPS55122784A (en) 1979-03-16 1979-03-16 Novel acetic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS55122784A true JPS55122784A (en) 1980-09-20
JPS6347714B2 JPS6347714B2 (en) 1988-09-26

Family

ID=12291510

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2999579A Granted JPS55122784A (en) 1979-03-16 1979-03-16 Novel acetic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS55122784A (en)

Also Published As

Publication number Publication date
JPS6347714B2 (en) 1988-09-26

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