JPS56154439A - Ml-236c derivative - Google Patents

Ml-236c derivative

Info

Publication number
JPS56154439A
JPS56154439A JP5721080A JP5721080A JPS56154439A JP S56154439 A JPS56154439 A JP S56154439A JP 5721080 A JP5721080 A JP 5721080A JP 5721080 A JP5721080 A JP 5721080A JP S56154439 A JPS56154439 A JP S56154439A
Authority
JP
Japan
Prior art keywords
formula
carboxylic
reaction
metal salt
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5721080A
Other languages
Japanese (ja)
Other versions
JPS6253494B2 (en
Inventor
Akira Terahara
Minoru Kitami
Yoshio Tsujita
Kunio Nakano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP5721080A priority Critical patent/JPS56154439A/en
Publication of JPS56154439A publication Critical patent/JPS56154439A/en
Publication of JPS6253494B2 publication Critical patent/JPS6253494B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:ML-236C derivatives shown by formula I [R is alkyl, benzyl which may be substituted with alkyl, alkoxy or halogen, formula II (M is metallic element)].
EXAMPLE: ML-236C methyl ester.
USE: Cholesterol synthesis inhibitor in livers: they have stronger activity than ML- 236C and are used as a remedy for hyperlipemia or prophylactic for arteriosclerosis.
PREPARATION: ML-236C of formula III is saponified with a weak alkali to produce a carboxylic metal salt of formula I. Or, (a) the reaction of a compound of formula III with an alcohol, (b) the reaction of the carboxylic metal salt cited above with an alkyl halide or (c) the neutralization of the above carboxylic metal salt, followed by reaction of the resultant free ML-236C carboxylic acid with an alcohol, affords a carboxylic ester of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP5721080A 1980-04-30 1980-04-30 Ml-236c derivative Granted JPS56154439A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5721080A JPS56154439A (en) 1980-04-30 1980-04-30 Ml-236c derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5721080A JPS56154439A (en) 1980-04-30 1980-04-30 Ml-236c derivative

Publications (2)

Publication Number Publication Date
JPS56154439A true JPS56154439A (en) 1981-11-30
JPS6253494B2 JPS6253494B2 (en) 1987-11-10

Family

ID=13049146

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5721080A Granted JPS56154439A (en) 1980-04-30 1980-04-30 Ml-236c derivative

Country Status (1)

Country Link
JP (1) JPS56154439A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018505884A (en) * 2015-02-04 2018-03-01 ベイジン ペキン ユニバーシティ ダブリュビーエル バイオテック カンパニー，リミティド Compound, its separation method, synthesis method and use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018505884A (en) * 2015-02-04 2018-03-01 ベイジン ペキン ユニバーシティ ダブリュビーエル バイオテック カンパニー，リミティド Compound, its separation method, synthesis method and use

Also Published As

Publication number Publication date
JPS6253494B2 (en) 1987-11-10

Similar Documents

Publication Publication Date Title
JPS5520751A (en) Pyrrolidine derivative
JPS5559140A (en) 3,5-dihydroxypentanoic alkyl ester derivative, its preparation and remedy for hyperlipemia containing the same as the effective component
JPS5278848A (en) Preparation of novel propionic acid ester derivatives
JPS56142236A (en) Ml-236a and mb-530a derivative
JPS56154439A (en) Ml-236c derivative
JPS5547655A (en) N-substituted derivative of moranoline
JPS53135958A (en) Substituted phenylacetic acid derivatives and their preparation
JPS559060A (en) Thia(oxa)zolidinecarboxylic acid derivative and its prepatation
JPS5531022A (en) Hydroxamic acid derivative and its preparation
JPS55147257A (en) Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component
JPS57126427A (en) Preparation of 1-substituted-azulene derivative
JPS55143973A (en) Phenylacetic acid derivative
JPS5651441A (en) O- n-allyl-2,6-dichloroanilino phenylacetic acid derivative and its preparation
JPS5592363A (en) New 2-azetidinone derivative
JPS56158786A (en) Novel camptothecin derivative and its preparation
JPS5673064A (en) Isoquinoline derivative
JPS5384937A (en) Preparation of novel aromatic carboxylic acid amide derivatives
JPS55120591A (en) Phosphinoethylmalonic acid derivative, and preparation thereof
JPS53124288A (en) 7alpha-alkoxy-7beta-amino-3-trifluoromethyl-sephalosporin derivatives and their preparation
JPS53149924A (en) Beta-hydroxy-alpha-amino acid compound and its preparation
JPS53108951A (en) Cyclopropanecarboxylic acid derivative and its production
JPS56167622A (en) Hypolipemic
JPS55122784A (en) Novel acetic acid derivative and its preparation
JPS5545615A (en) Derivative of (n-allyl-o-(2,6-dichloroanilino) phenyl) acetic acid
JPS56145261A (en) Novel oxyacetic acid derivative, its preparation, and lowering agent of lipid in blood comprising it as active ingredient