JPS5748971A - Novel alkylimidazole derivative - Google Patents
Novel alkylimidazole derivativeInfo
- Publication number
- JPS5748971A JPS5748971A JP55124974A JP12497480A JPS5748971A JP S5748971 A JPS5748971 A JP S5748971A JP 55124974 A JP55124974 A JP 55124974A JP 12497480 A JP12497480 A JP 12497480A JP S5748971 A JPS5748971 A JP S5748971A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- give
- aralkyl
- reacted
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- GFQBSQXXHYLABK-UHFFFAOYSA-N 2-aminopropanediamide Chemical class NC(=O)C(N)C(N)=O GFQBSQXXHYLABK-UHFFFAOYSA-N 0.000 abstract 1
- KDBUUJSOUXNTOE-UHFFFAOYSA-N 2-bromopropanediamide Chemical compound NC(=O)C(Br)C(N)=O KDBUUJSOUXNTOE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229940049964 oleate Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An imidazole derivative shown by the formula I(R1 is lower alkyl or aralkyl; R2 and R3 are H, lower alkyl or aralkyl) and its salt.
EXAMPLE: 5-Carbamoyl-1-methylimidazolium-4-oleate.
USE: An anti-inflammatory agent. Having improved inhibiting actions on calabar swelling.
PROCESS: An amine shown by the formula R1-NH2 is reacted with α-bromomalonamide shown by the formula II to give an α-aminomalonamide derivative shown by the formula III, which is reacted with an ortho-formate in the presence or absence of a catalyst to give a compound shown by the formula IV. If, necessary, this compound is reacted with an alkylating agent to give a compound shown by the formula V(R'2 is lower alkyl or aralkyl), and optionally treated with an alkali to give a rearranged reaction product shown by the formula VI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55124974A JPS5748971A (en) | 1980-09-08 | 1980-09-08 | Novel alkylimidazole derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55124974A JPS5748971A (en) | 1980-09-08 | 1980-09-08 | Novel alkylimidazole derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5748971A true JPS5748971A (en) | 1982-03-20 |
Family
ID=14898815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55124974A Pending JPS5748971A (en) | 1980-09-08 | 1980-09-08 | Novel alkylimidazole derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5748971A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008006432A1 (en) | 2006-07-13 | 2008-01-17 | Merck Patent Gmbh | Use of ampk-activating imidazole derivatives, preparation process therefor and pharmaceutical compositions comprising them |
| JP2015040826A (en) * | 2013-08-23 | 2015-03-02 | 日立Ｇｅニュークリア・エナジー株式会社 | Radioactive waste liquid disposal method, and radioactive waste liquid disposal device |
| JP2015059870A (en) * | 2013-09-19 | 2015-03-30 | 日立Ｇｅニュークリア・エナジー株式会社 | Radioactive waste liquid treatment method and radioactive waste liquid treatment apparatus |
| JP2015059852A (en) * | 2013-09-19 | 2015-03-30 | 日立Ｇｅニュークリア・エナジー株式会社 | Method for treating radioactive waste liquid and apparatus for treating radioactive waste liquid |
-
1980
- 1980-09-08 JP JP55124974A patent/JPS5748971A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008006432A1 (en) | 2006-07-13 | 2008-01-17 | Merck Patent Gmbh | Use of ampk-activating imidazole derivatives, preparation process therefor and pharmaceutical compositions comprising them |
| FR2903695A1 (en) * | 2006-07-13 | 2008-01-18 | Merck Sante Soc Par Actions Si | USE OF AMPAP ACTIVATOR IMIDAZOLE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| JP2009542734A (en) * | 2006-07-13 | 2009-12-03 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Use of AMPK-activated imidazole derivatives, process for their preparation and pharmaceutical compositions containing them |
| US8329738B2 (en) | 2006-07-13 | 2012-12-11 | MERCK Patent Gesellschaft mit beschränkter Haftung | Use of AMPK-activating imidazole derivatives, preparation process therefor and pharmaceutical compositions comprising them |
| JP2015040826A (en) * | 2013-08-23 | 2015-03-02 | 日立Ｇｅニュークリア・エナジー株式会社 | Radioactive waste liquid disposal method, and radioactive waste liquid disposal device |
| JP2015059870A (en) * | 2013-09-19 | 2015-03-30 | 日立Ｇｅニュークリア・エナジー株式会社 | Radioactive waste liquid treatment method and radioactive waste liquid treatment apparatus |
| JP2015059852A (en) * | 2013-09-19 | 2015-03-30 | 日立Ｇｅニュークリア・エナジー株式会社 | Method for treating radioactive waste liquid and apparatus for treating radioactive waste liquid |
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