JPS5639092A - Penicillin derivative - Google Patents

Penicillin derivative

Info

Publication number
JPS5639092A
JPS5639092A JP11281079A JP11281079A JPS5639092A JP S5639092 A JPS5639092 A JP S5639092A JP 11281079 A JP11281079 A JP 11281079A JP 11281079 A JP11281079 A JP 11281079A JP S5639092 A JPS5639092 A JP S5639092A
Authority
JP
Japan
Prior art keywords
formula
alkyl
penicillin
compound
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11281079A
Other languages
Japanese (ja)
Other versions
JPS6058238B2 (en
Inventor
Kiyotaka Ono
Hiroshi Nagase
Masaji Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP11281079A priority Critical patent/JPS6058238B2/en
Publication of JPS5639092A publication Critical patent/JPS5639092A/en
Publication of JPS6058238B2 publication Critical patent/JPS6058238B2/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A penicillin derivative of formula I [R1 is H, alkyl, cycloalkyl, aralkyl, etc. ; X is H or OH; A is a group of formula II (R2 and R3 are H, alkyl, phenyl, etc.) or formula III (R4 is H or thiophenoxymethyl; R5 is H, alkyl, etc.)].
EXAMPLE: Benzyl 6-[N-[5(2H)-oxazolon-4-yl]-D-α-phenylglycylamido]-penicillate.
USE: An antimicrobial agent having an antimicrobial activity against a wide variety of pathogenic microorganisms, particularly mycobacteria against which the existing penicillin is ineffective. Characterized by the amidinolactone or amidinecarboxylic acid introduced into the side chain of the penicillin.
PROCESS: A compound of formula IV is reacted with a compound of formula V (R' is alkyl, benzyl, etc.), and if necessary the reaction product is catalytically reduced to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP11281079A 1979-09-05 1979-09-05 penicillin derivatives Expired JPS6058238B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11281079A JPS6058238B2 (en) 1979-09-05 1979-09-05 penicillin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11281079A JPS6058238B2 (en) 1979-09-05 1979-09-05 penicillin derivatives

Publications (2)

Publication Number Publication Date
JPS5639092A true JPS5639092A (en) 1981-04-14
JPS6058238B2 JPS6058238B2 (en) 1985-12-19

Family

ID=14596092

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11281079A Expired JPS6058238B2 (en) 1979-09-05 1979-09-05 penicillin derivatives

Country Status (1)

Country Link
JP (1) JPS6058238B2 (en)

Also Published As

Publication number Publication date
JPS6058238B2 (en) 1985-12-19

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