JPS5639092A - Penicillin derivative - Google Patents
Penicillin derivativeInfo
- Publication number
- JPS5639092A JPS5639092A JP11281079A JP11281079A JPS5639092A JP S5639092 A JPS5639092 A JP S5639092A JP 11281079 A JP11281079 A JP 11281079A JP 11281079 A JP11281079 A JP 11281079A JP S5639092 A JPS5639092 A JP S5639092A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- penicillin
- compound
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A penicillin derivative of formula I [R1 is H, alkyl, cycloalkyl, aralkyl, etc. ; X is H or OH; A is a group of formula II (R2 and R3 are H, alkyl, phenyl, etc.) or formula III (R4 is H or thiophenoxymethyl; R5 is H, alkyl, etc.)].
EXAMPLE: Benzyl 6-[N-[5(2H)-oxazolon-4-yl]-D-α-phenylglycylamido]-penicillate.
USE: An antimicrobial agent having an antimicrobial activity against a wide variety of pathogenic microorganisms, particularly mycobacteria against which the existing penicillin is ineffective. Characterized by the amidinolactone or amidinecarboxylic acid introduced into the side chain of the penicillin.
PROCESS: A compound of formula IV is reacted with a compound of formula V (R' is alkyl, benzyl, etc.), and if necessary the reaction product is catalytically reduced to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11281079A JPS6058238B2 (en) | 1979-09-05 | 1979-09-05 | penicillin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11281079A JPS6058238B2 (en) | 1979-09-05 | 1979-09-05 | penicillin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5639092A true JPS5639092A (en) | 1981-04-14 |
JPS6058238B2 JPS6058238B2 (en) | 1985-12-19 |
Family
ID=14596092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11281079A Expired JPS6058238B2 (en) | 1979-09-05 | 1979-09-05 | penicillin derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6058238B2 (en) |
-
1979
- 1979-09-05 JP JP11281079A patent/JPS6058238B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6058238B2 (en) | 1985-12-19 |
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