JPS56147757A - Amino acid derivative - Google Patents
Amino acid derivativeInfo
- Publication number
- JPS56147757A JPS56147757A JP5138680A JP5138680A JPS56147757A JP S56147757 A JPS56147757 A JP S56147757A JP 5138680 A JP5138680 A JP 5138680A JP 5138680 A JP5138680 A JP 5138680A JP S56147757 A JPS56147757 A JP S56147757A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- amino acid
- acid derivative
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:An amino acid derivative of formula I (R is 1W5C alkyl; n is an integer 1W5).
EXAMPLE: Nω-n-Butoxycarbonylaminomethyl-L-citrulline.
USE: Useful as a carcinostatic agent having a carcinostatic activity with low toxicity (LD50 value ≥1.5g/kg in a mouse orally).
PROCESS: An amino acid of formula II is reacted with a copper salt, e.g. copper sulfate, and an isocyanate to give a reaction product, which is treated with a cation exchange resin to afford a compound of formula III. The resultant compound of formula III is then reacted with HCHO and a carbamic ester to give a compound of formula IV, which is then heated in an aqueous solution containing a lower alcohol e.g. methanol, to afford the compound of formula I. Preferably, the carbamic ester in which the alcohol part is 1W5C alcohol is used as the carbamic ester, and 30W40% formalin is used as the HCHO.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5138680A JPS56147757A (en) | 1980-04-18 | 1980-04-18 | Amino acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5138680A JPS56147757A (en) | 1980-04-18 | 1980-04-18 | Amino acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56147757A true JPS56147757A (en) | 1981-11-16 |
Family
ID=12885500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5138680A Pending JPS56147757A (en) | 1980-04-18 | 1980-04-18 | Amino acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56147757A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7030214B2 (en) | 1993-06-18 | 2006-04-18 | Solvay (Societe Anonyme) | Ureins derived from α, ω, diamino acids and process for their preparation |
-
1980
- 1980-04-18 JP JP5138680A patent/JPS56147757A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7030214B2 (en) | 1993-06-18 | 2006-04-18 | Solvay (Societe Anonyme) | Ureins derived from α, ω, diamino acids and process for their preparation |
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