JPS56147757A - Amino acid derivative - Google Patents

Amino acid derivative

Info

Publication number
JPS56147757A
JPS56147757A JP5138680A JP5138680A JPS56147757A JP S56147757 A JPS56147757 A JP S56147757A JP 5138680 A JP5138680 A JP 5138680A JP 5138680 A JP5138680 A JP 5138680A JP S56147757 A JPS56147757 A JP S56147757A
Authority
JP
Japan
Prior art keywords
formula
compound
amino acid
acid derivative
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5138680A
Other languages
Japanese (ja)
Inventor
Shigeru Toyoshima
Hirokazu Ryono
Tadashi Suyama
Kenichi Fukuhara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP5138680A priority Critical patent/JPS56147757A/en
Publication of JPS56147757A publication Critical patent/JPS56147757A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:An amino acid derivative of formula I (R is 1W5C alkyl; n is an integer 1W5).
EXAMPLE: Nω-n-Butoxycarbonylaminomethyl-L-citrulline.
USE: Useful as a carcinostatic agent having a carcinostatic activity with low toxicity (LD50 value ≥1.5g/kg in a mouse orally).
PROCESS: An amino acid of formula II is reacted with a copper salt, e.g. copper sulfate, and an isocyanate to give a reaction product, which is treated with a cation exchange resin to afford a compound of formula III. The resultant compound of formula III is then reacted with HCHO and a carbamic ester to give a compound of formula IV, which is then heated in an aqueous solution containing a lower alcohol e.g. methanol, to afford the compound of formula I. Preferably, the carbamic ester in which the alcohol part is 1W5C alcohol is used as the carbamic ester, and 30W40% formalin is used as the HCHO.
COPYRIGHT: (C)1981,JPO&Japio
JP5138680A 1980-04-18 1980-04-18 Amino acid derivative Pending JPS56147757A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5138680A JPS56147757A (en) 1980-04-18 1980-04-18 Amino acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5138680A JPS56147757A (en) 1980-04-18 1980-04-18 Amino acid derivative

Publications (1)

Publication Number Publication Date
JPS56147757A true JPS56147757A (en) 1981-11-16

Family

ID=12885500

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5138680A Pending JPS56147757A (en) 1980-04-18 1980-04-18 Amino acid derivative

Country Status (1)

Country Link
JP (1) JPS56147757A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7030214B2 (en) 1993-06-18 2006-04-18 Solvay (Societe Anonyme) Ureins derived from α, ω, diamino acids and process for their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7030214B2 (en) 1993-06-18 2006-04-18 Solvay (Societe Anonyme) Ureins derived from α, ω, diamino acids and process for their preparation

Similar Documents

Publication Publication Date Title
JPS5668674A (en) 5-fluorouracil derivative
JPS5227721A (en) Process for preparation of substituted phosphonic acid derivatives
JPS56147757A (en) Amino acid derivative
JPS57118555A (en) Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component
JPS5655359A (en) Halogenated alpha-amino acid, and its preparation
JPS5740496A (en) Low toxic derivative of istamycin antibiotic
JPS56158797A (en) Novel d-allose derivative and antitumor agnet comprising it as active ingredient
JPS5748971A (en) Novel alkylimidazole derivative
JPS54151985A (en) Preparation of aminocarbostyril derivative
JPS5557578A (en) Carbamoylpiperazine derivative
JPS557225A (en) Preparation of propionic acid derivative
JPS5721400A (en) Novel fortimicin derivative
JPS5716877A (en) Production of polyalkyl-2- 2,4-dihydroxyphenyl -7-hydroxy- chroman
JPS579749A (en) Acyl derivative and its preparation
JPS56128769A (en) Amino-5-fluorouracil derivative and its preparation
JPS552638A (en) Cyanopyrazinecarboxylic ester and its preparation
JPS54112862A (en) N-(omega-substituted alkyl)imidazole
JPS5673069A (en) Pyrazolecarboxylic acid derivative
JPS54109974A (en) Novel imidazolecarboxylic ester derivative
JPS56158786A (en) Novel camptothecin derivative and its preparation
JPS55136239A (en) Z-10-alkenal
JPS56161388A (en) Novel vincamine derivative
JPS56118070A (en) 1,3,8,9-tetraalkoxyphenanthridinium salt
JPS5770860A (en) Carboxylic acid derivative and its salt
JPS54122281A (en) 5-fluorouracil derivative and its preparation