JPS56166158A - Novel benzyloxycarbonyl-leucyl-leucyl-valyl-4-amino-3- hydroxy-6-methyl-heptanoyl-alanine and its preparation - Google Patents

Novel benzyloxycarbonyl-leucyl-leucyl-valyl-4-amino-3- hydroxy-6-methyl-heptanoyl-alanine and its preparation

Info

Publication number
JPS56166158A
JPS56166158A JP6956080A JP6956080A JPS56166158A JP S56166158 A JPS56166158 A JP S56166158A JP 6956080 A JP6956080 A JP 6956080A JP 6956080 A JP6956080 A JP 6956080A JP S56166158 A JPS56166158 A JP S56166158A
Authority
JP
Japan
Prior art keywords
leucyl
formula
heptanoyl
valyl
alanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6956080A
Other languages
Japanese (ja)
Other versions
JPS6332800B2 (en
Inventor
Noriaki Kuwana
Yoshikazu Hasegawa
Yukio Nozu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP6956080A priority Critical patent/JPS56166158A/en
Publication of JPS56166158A publication Critical patent/JPS56166158A/en
Publication of JPS6332800B2 publication Critical patent/JPS6332800B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:The titled compound of formula I.
USE: A drug substance usefuel for the prevention and remedy of various diseases caused by hypersecretion of pepsin, e.g. peptic ulcer, having a powerful antipepsin activity without antirenin activity.
PROCESS: Valyl-4-amino-3-hydroxyl-6-methyl-heptanoyl-alanine of formula II is reacted with an N-protected leucine ester to remove the protecting group of the N atom. The resultant leucyl-valyl-4-amino-3-hydroxy-6-methyl-heptanoyl-alanine is then reacted with a benzyloxycarbonylleucine ester to give the compound of formula I. The starting material compound of formula II is a novel substance and obtained by treating a desacylvalylpepsidin with a strongly acidic ion exchange resin.
COPYRIGHT: (C)1981,JPO&Japio
JP6956080A 1980-05-27 1980-05-27 Novel benzyloxycarbonyl-leucyl-leucyl-valyl-4-amino-3- hydroxy-6-methyl-heptanoyl-alanine and its preparation Granted JPS56166158A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6956080A JPS56166158A (en) 1980-05-27 1980-05-27 Novel benzyloxycarbonyl-leucyl-leucyl-valyl-4-amino-3- hydroxy-6-methyl-heptanoyl-alanine and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6956080A JPS56166158A (en) 1980-05-27 1980-05-27 Novel benzyloxycarbonyl-leucyl-leucyl-valyl-4-amino-3- hydroxy-6-methyl-heptanoyl-alanine and its preparation

Publications (2)

Publication Number Publication Date
JPS56166158A true JPS56166158A (en) 1981-12-21
JPS6332800B2 JPS6332800B2 (en) 1988-07-01

Family

ID=13406252

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6956080A Granted JPS56166158A (en) 1980-05-27 1980-05-27 Novel benzyloxycarbonyl-leucyl-leucyl-valyl-4-amino-3- hydroxy-6-methyl-heptanoyl-alanine and its preparation

Country Status (1)

Country Link
JP (1) JPS56166158A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007062003A (en) * 2005-09-01 2007-03-15 Kowa Co Ltd Wheel brush

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007062003A (en) * 2005-09-01 2007-03-15 Kowa Co Ltd Wheel brush

Also Published As

Publication number Publication date
JPS6332800B2 (en) 1988-07-01

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