JPS56158754A - Preparation of p-ethoxycarbonylphenyl epsilon-guanidinocaproate - Google Patents

Preparation of p-ethoxycarbonylphenyl epsilon-guanidinocaproate

Info

Publication number
JPS56158754A
JPS56158754A JP6249980A JP6249980A JPS56158754A JP S56158754 A JPS56158754 A JP S56158754A JP 6249980 A JP6249980 A JP 6249980A JP 6249980 A JP6249980 A JP 6249980A JP S56158754 A JPS56158754 A JP S56158754A
Authority
JP
Japan
Prior art keywords
ethyl
formula
titled compound
hydroxybenzoate
benzoate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6249980A
Other languages
Japanese (ja)
Inventor
Kunio Takahashi
Original Assignee
Shiratori Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiratori Seiyaku Kk filed Critical Shiratori Seiyaku Kk
Priority to JP6249980A priority Critical patent/JPS56158754A/en
Publication of JPS56158754A publication Critical patent/JPS56158754A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound useful as an anticallicrein agent in high yield, by reacting a specific compound with ethyl p-hydroxybenzoate in the presence or absence of a condensing agent, and reducing the resultant ethyl p-(ε-nitroguanidinohexanyloxy)benzoate.
CONSTITUTION: ε-Nitroguanidinocaproic acid of formula II or a reactive derivative thereof, e.g. an acid halogenide, is reacted with ethyl p-hydroxybenzoate of formula III in the presence or absence of a condensing agent, e.g. N,N'-dicyclohexylcarbodiimide, to give ethyl p-(ε-nitroguanidinohexanoyloxy)benzoate of formula IV, which is then reduced to afford the titled compound of formula I. The reducing reaction is preferably carried out catalytically by using Pd, etc. as a catalyst.
EFFECT: The titled compound has an inhibitory action on the hydrolysis of tosyl- L-arginine methyl ester by callicrein.
COPYRIGHT: (C)1981,JPO&Japio
JP6249980A 1980-05-12 1980-05-12 Preparation of p-ethoxycarbonylphenyl epsilon-guanidinocaproate Pending JPS56158754A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6249980A JPS56158754A (en) 1980-05-12 1980-05-12 Preparation of p-ethoxycarbonylphenyl epsilon-guanidinocaproate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6249980A JPS56158754A (en) 1980-05-12 1980-05-12 Preparation of p-ethoxycarbonylphenyl epsilon-guanidinocaproate

Publications (1)

Publication Number Publication Date
JPS56158754A true JPS56158754A (en) 1981-12-07

Family

ID=13201912

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6249980A Pending JPS56158754A (en) 1980-05-12 1980-05-12 Preparation of p-ethoxycarbonylphenyl epsilon-guanidinocaproate

Country Status (1)

Country Link
JP (1) JPS56158754A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59134773A (en) * 1983-01-24 1984-08-02 Paamakemu Asia:Kk Preparation of 6-guanidinocaproic acid p-alkoxy-carbonylphenyl ester

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59134773A (en) * 1983-01-24 1984-08-02 Paamakemu Asia:Kk Preparation of 6-guanidinocaproic acid p-alkoxy-carbonylphenyl ester
JPS6338346B2 (en) * 1983-01-24 1988-07-29 Paamakemu Ajia Kk

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