JPS5655383A - Amizine derivative and its preparation - Google Patents
Amizine derivative and its preparationInfo
- Publication number
- JPS5655383A JPS5655383A JP13157779A JP13157779A JPS5655383A JP S5655383 A JPS5655383 A JP S5655383A JP 13157779 A JP13157779 A JP 13157779A JP 13157779 A JP13157779 A JP 13157779A JP S5655383 A JPS5655383 A JP S5655383A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- lower alkyl
- compound
- amizine
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ODCWYMIRDDJXKW-UHFFFAOYSA-N simazine Chemical class CCNC1=NC(Cl)=NC(NCC)=N1 ODCWYMIRDDJXKW-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000001412 amines Chemical class 0.000 abstract 2
- -1 2-guanidinothiazol-4-yl Chemical group 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 210000004051 gastric juice Anatomy 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An amizine derivative of formula I (R is H, lower alkyl, or OH; m and n are 1W3; R1 is lower alkyl, halogeno-lower alkyl, OH, etc.; R2 is H, lower alkyl, lower alkenyl, etc.) and its acid addition salt.
EXAMPLE: N-Sulfamoyl-3-[(2-guanidinothiazol-4-yl)methylthio]propionamizine.
USE: A gastric juice secretion suppressing agent. The mechanism of the action is not cholinergic. Administrable orally or parenterally.
PROCESS: The compound of formula I is prepared either by the reaction of a compound of formula II1 (R' is lower alkyl) with an amine of formula III1, or the reaction of a compound of formula II2 with an amine of formula III2. The reactions are carried out in a solvent such as alcohol, etc., at room temperature or with heating.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13157779A JPS5655383A (en) | 1979-10-12 | 1979-10-12 | Amizine derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13157779A JPS5655383A (en) | 1979-10-12 | 1979-10-12 | Amizine derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5655383A true JPS5655383A (en) | 1981-05-15 |
| JPS6256872B2 JPS6256872B2 (en) | 1987-11-27 |
Family
ID=15061298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13157779A Granted JPS5655383A (en) | 1979-10-12 | 1979-10-12 | Amizine derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5655383A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3644246A1 (en) * | 1986-06-20 | 1987-12-23 | Uriach & Cia Sa J | Process for the preparation of 3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulp honyl)propaneimideamide |
| JPS6399065A (en) * | 1986-08-05 | 1988-04-30 | リヒタ− ゲデオン ベジエセテイ ジヤ−ル ア−ル．テ−． | Method for producing morphologically homogeneous thiazole derivatives |
| US4748165A (en) * | 1981-05-18 | 1988-05-31 | Imperial Chemical Industries Plc | Amidine derivatives |
| US4942243A (en) * | 1988-03-11 | 1990-07-17 | Hanil Pharmaceutical Ind., Co., Ltd. | Process for preparing N"-[4-[[(2-cyanoethyl)thio]methyl]-2-thiazolyl]guanidine |
-
1979
- 1979-10-12 JP JP13157779A patent/JPS5655383A/en active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4748165A (en) * | 1981-05-18 | 1988-05-31 | Imperial Chemical Industries Plc | Amidine derivatives |
| DE3644246A1 (en) * | 1986-06-20 | 1987-12-23 | Uriach & Cia Sa J | Process for the preparation of 3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulp honyl)propaneimideamide |
| JPS6399065A (en) * | 1986-08-05 | 1988-04-30 | リヒタ− ゲデオン ベジエセテイ ジヤ−ル ア−ル．テ−． | Method for producing morphologically homogeneous thiazole derivatives |
| JPH07316141A (en) * | 1986-08-05 | 1995-12-05 | Richter Gedeon V G Rt | Method for producing morphologically homogeneous thiazole derivative |
| US4942243A (en) * | 1988-03-11 | 1990-07-17 | Hanil Pharmaceutical Ind., Co., Ltd. | Process for preparing N"-[4-[[(2-cyanoethyl)thio]methyl]-2-thiazolyl]guanidine |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6256872B2 (en) | 1987-11-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5432460A (en) | Cycloalkylidenemethylphenylacetic acid derivative and their preparation | |
| AU534361B2 (en) | Processes | |
| JPS5655383A (en) | Amizine derivative and its preparation | |
| JPS57163393A (en) | Novel anthracyclin derivative and its preparation | |
| JPS5540628A (en) | Novel hydroxamic acid compound, its preparation, and medicine containing the same | |
| JPS5528955A (en) | Novel glycerophosphoric acid derivative, its salt, their preparation, and carcinostatic agent containing the same. | |
| JPS5645454A (en) | Cyclohexanecarboxylic acid derivative and its preparation | |
| JPS56108777A (en) | Novel guanidinothiazole derivative and its preparation | |
| JPS565469A (en) | Novel amidine derivative and its preparation | |
| JPS5618971A (en) | Alpha-halogeno-beta-benzosulfimidopropionitrile and its preparation | |
| JPS5753469A (en) | 5-fluorouracil derivative, its preparation and use | |
| JPS554324A (en) | Novel glycopyranosidoamine derivative, its preparation, and antitumor agent comprising it as active constituent | |
| JPS54128583A (en) | Thiosemicarbazone derivative | |
| JPS55105681A (en) | Production of novel thienyltriazoles | |
| JPS57193444A (en) | Sulfonate derivative, its preparation and antilipemic agent containing the same | |
| JPS5217441A (en) | Process for preparation of p-cyanophenylester of 4-substituted- benzoi c acid | |
| JPS5262295A (en) | Preparation of n1-oxy-2-thioadenosines | |
| JPS5279081A (en) | Preparation of novel 7-methoxycephalosporins | |
| JPS5572151A (en) | Threo-(2rs)-3-amino-2-hydroxy-4-oxo-4-phenylbutyric acid, its ester, and their preparation | |
| JPS53108943A (en) | Pheganomycin antibiotics | |
| JPS54138544A (en) | Preparation of alpha-methylbenzyl isocyanate or its nuclear substitution product | |
| JPS57185283A (en) | Preparation of aminoalcohol derivative | |
| JPS55118487A (en) | Novel preparation of xanthine derivative | |
| JPS545043A (en) | Digestive ulcer remedy containing polyprenylcarboxylic | |
| JPS51141818A (en) | Process for preparation of 2-arylazocyanoacetylguanidine |