JPS5576866A - Preparation of 5-fluorouracil derivative - Google Patents
Preparation of 5-fluorouracil derivativeInfo
- Publication number
- JPS5576866A JPS5576866A JP15123278A JP15123278A JPS5576866A JP S5576866 A JPS5576866 A JP S5576866A JP 15123278 A JP15123278 A JP 15123278A JP 15123278 A JP15123278 A JP 15123278A JP S5576866 A JPS5576866 A JP S5576866A
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- formula
- oxopyrimidine
- derivative
- substituted benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 4-substituted benzyl-5-fluoro-1H-2-oxopyrimidine derivative of formula I: (R1, R2, and R3 are H or lower alkoxy groups, except when they are H atoms, one of them is H and the adjacent two others form a lower alkylenedioxy group).
EXAMPLE: 5-Fluoro-4-piperonyloxy-1H-2-oxopyrimidine.
USE: Carcinostatics.
PROCESS: An 4-alkylthio-5-fluoro-pyrimidine derivative of formula III: (R4 is alkyl group) is reacted with a metallic salt of a substituted benzyl alcohol of formula IV: (M is alkali metal) to give the objective compound of formula I. The starting compound of formula III stable to acids and alkalis, is obtained by reacting 4-thio-5- fluoro-uracil with an alkyl halide in the presence of an alkali.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15123278A JPS5576866A (en) | 1978-12-06 | 1978-12-06 | Preparation of 5-fluorouracil derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15123278A JPS5576866A (en) | 1978-12-06 | 1978-12-06 | Preparation of 5-fluorouracil derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5576866A true JPS5576866A (en) | 1980-06-10 |
Family
ID=15514124
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15123278A Pending JPS5576866A (en) | 1978-12-06 | 1978-12-06 | Preparation of 5-fluorouracil derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5576866A (en) |
-
1978
- 1978-12-06 JP JP15123278A patent/JPS5576866A/en active Pending
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