JPS5576866A - Preparation of 5-fluorouracil derivative - Google Patents

Preparation of 5-fluorouracil derivative

Info

Publication number
JPS5576866A
JPS5576866A JP15123278A JP15123278A JPS5576866A JP S5576866 A JPS5576866 A JP S5576866A JP 15123278 A JP15123278 A JP 15123278A JP 15123278 A JP15123278 A JP 15123278A JP S5576866 A JPS5576866 A JP S5576866A
Authority
JP
Japan
Prior art keywords
fluoro
formula
oxopyrimidine
derivative
substituted benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15123278A
Other languages
Japanese (ja)
Inventor
Masakatsu Kaneko
Bunji Shimizu
Yorio Arakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP15123278A priority Critical patent/JPS5576866A/en
Publication of JPS5576866A publication Critical patent/JPS5576866A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 4-substituted benzyl-5-fluoro-1H-2-oxopyrimidine derivative of formula I: (R1, R2, and R3 are H or lower alkoxy groups, except when they are H atoms, one of them is H and the adjacent two others form a lower alkylenedioxy group).
EXAMPLE: 5-Fluoro-4-piperonyloxy-1H-2-oxopyrimidine.
USE: Carcinostatics.
PROCESS: An 4-alkylthio-5-fluoro-pyrimidine derivative of formula III: (R4 is alkyl group) is reacted with a metallic salt of a substituted benzyl alcohol of formula IV: (M is alkali metal) to give the objective compound of formula I. The starting compound of formula III stable to acids and alkalis, is obtained by reacting 4-thio-5- fluoro-uracil with an alkyl halide in the presence of an alkali.
COPYRIGHT: (C)1980,JPO&Japio
JP15123278A 1978-12-06 1978-12-06 Preparation of 5-fluorouracil derivative Pending JPS5576866A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15123278A JPS5576866A (en) 1978-12-06 1978-12-06 Preparation of 5-fluorouracil derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15123278A JPS5576866A (en) 1978-12-06 1978-12-06 Preparation of 5-fluorouracil derivative

Publications (1)

Publication Number Publication Date
JPS5576866A true JPS5576866A (en) 1980-06-10

Family

ID=15514124

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15123278A Pending JPS5576866A (en) 1978-12-06 1978-12-06 Preparation of 5-fluorouracil derivative

Country Status (1)

Country Link
JP (1) JPS5576866A (en)

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