JPS5598171A - 5-fluorouracil derivative and its preparation - Google Patents
5-fluorouracil derivative and its preparationInfo
- Publication number
- JPS5598171A JPS5598171A JP399379A JP399379A JPS5598171A JP S5598171 A JPS5598171 A JP S5598171A JP 399379 A JP399379 A JP 399379A JP 399379 A JP399379 A JP 399379A JP S5598171 A JPS5598171 A JP S5598171A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- fluorouracil
- preparation
- oxidizing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 5-fluorouracil derivative of formula I (R is alkyl or aryl group) or formula II.
EXAMPLE: 1-Methylsulfinylmethyl-5-fluorouracil.
USE: Carcinostatic activities.
PROCESS: A 1-thiomethyl-5-fluorouracil (F), e.g. 1-methylthiomethyl-5-fluorouracil, is oxidized with an oxidizing agent (A), e.g. sodium periodate, in a solvent of preferably water, to give the objective compound of formula I or II. The compound of formula II is also obtained by the action of an oxidizing agent on the compound of formula I. The agent (A) is used in on equimolar amount or slight excess of F at a low temperature of 0W10°C for the compound of formula I, and in a molar amount of twice or more that of F at a higher temperature of 80W110°C for the compound of formula II.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP399379A JPS5598171A (en) | 1979-01-19 | 1979-01-19 | 5-fluorouracil derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP399379A JPS5598171A (en) | 1979-01-19 | 1979-01-19 | 5-fluorouracil derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5598171A true JPS5598171A (en) | 1980-07-25 |
JPS6231711B2 JPS6231711B2 (en) | 1987-07-09 |
Family
ID=11572531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP399379A Granted JPS5598171A (en) | 1979-01-19 | 1979-01-19 | 5-fluorouracil derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5598171A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989010361A1 (en) * | 1988-04-27 | 1989-11-02 | Kyowa Hakko Kogyo Co., Ltd. | Novel compound and medicine containing same |
-
1979
- 1979-01-19 JP JP399379A patent/JPS5598171A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989010361A1 (en) * | 1988-04-27 | 1989-11-02 | Kyowa Hakko Kogyo Co., Ltd. | Novel compound and medicine containing same |
Also Published As
Publication number | Publication date |
---|---|
JPS6231711B2 (en) | 1987-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5297950A (en) | Chalconeether derivatives | |
JPS53119844A (en) | Optically active amino acid-mandelic acid complexes and theire preparation | |
JPS5395977A (en) | 1,4-dihydropyrimidine compounds and process for their preparation | |
JPS53119866A (en) | 5-aryloxy-oxazoleakanoic acid derivatives and their preparation | |
JPS5598171A (en) | 5-fluorouracil derivative and its preparation | |
JPS5424882A (en) | Novel heterocyclic compounds and their preparation | |
JPS5344572A (en) | 5-alkoxy-picolic acid, its preparation and hypotensives containing the same | |
JPS5359674A (en) | 1-piperidinoalkane-1,1-diphosphonic acid derivatives and herbicidescontaining the same as active agent | |
JPS527946A (en) | Preparation of indanylpropionic acid derivatives | |
JPS52100473A (en) | Novel azimidebenzamide derivative and its production | |
JPS5350182A (en) | Carbostyril derivatives | |
JPS5359656A (en) | Silacyclopropene derivatives and process for preparation of the same | |
JPS5353652A (en) | Novel imidazole derivatives | |
JPS5365882A (en) | 1,4-dihydro-4-oxonicotinic acids and process for preparation of the same | |
JPS52148036A (en) | Lysinol derivatives | |
JPS5328183A (en) | 1-carbamoyl-5-fluorouracil derivatives and thier preparation | |
JPS5350194A (en) | 77 44*alkanesulfoneamidephenyl**55oxoimidazolidinyl 33methyll 33cephemm44ca rboxlic acid derivatives | |
JPS5269491A (en) | Preparation of high polymeric selenium compounds | |
JPS525785A (en) | Preparation of s-containing penicillines | |
JPS52122387A (en) | 7alpha-methoxycephalosporin derivatives and their preparation | |
JPS5278868A (en) | Preparation of 5-(2-substituted phenyl-1-hydroxyethyl)-2-thenylacetic acids | |
JPS5321148A (en) | Stable cholesteric compound | |
JPS5356620A (en) | Cyanomethyl aminomethyl phosphonate derivatives and herbicides containingthe same as active constituents | |
JPS545976A (en) | 7-glycylprolylamino-4-methylcoumalin | |
JPS5279081A (en) | Preparation of novel 7-methoxycephalosporins |