SE8403897L - CEPHALOSPORINS - Google Patents
CEPHALOSPORINSInfo
- Publication number
- SE8403897L SE8403897L SE8403897A SE8403897A SE8403897L SE 8403897 L SE8403897 L SE 8403897L SE 8403897 A SE8403897 A SE 8403897A SE 8403897 A SE8403897 A SE 8403897A SE 8403897 L SE8403897 L SE 8403897L
- Authority
- SE
- Sweden
- Prior art keywords
- product
- cefuroxime axetil
- crystallisation
- admixture
- isomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for obtaining highly pure crystalline cefuroxime axetil comprises crystallising cefuroxime axetil from a solution thereof in an organic or aqueous solvent or a mixture thereof and then drying and isolating the product. Preferred solvents are alkyl acetates in admixture with ethers or aliphatic or aromatic hydrocarbons. The higher the yield from crystallisation, the closer to a 1:1 stoichiometric ratio of R:S isomers the product will contain, this being most desirable for an antibiotic product which is to be administered orally.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838320521A GB8320521D0 (en) | 1983-07-29 | 1983-07-29 | Chemical process |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8403897D0 SE8403897D0 (en) | 1984-07-27 |
SE8403897L true SE8403897L (en) | 1985-01-30 |
SE463263B SE463263B (en) | 1990-10-29 |
Family
ID=10546505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8403897A SE463263B (en) | 1983-07-29 | 1984-07-27 | PROCEDURES FOR THE PREPARATION OF CRYSTALLINE CEFUROXIM-1 ACETOXYTHYLESTER |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPH0613526B2 (en) |
KR (1) | KR910008377B1 (en) |
AT (1) | AT392470B (en) |
AU (2) | AU582121B2 (en) |
BE (1) | BE900241A (en) |
CA (1) | CA1265511A (en) |
CH (1) | CH662121A5 (en) |
DE (1) | DE3427828A1 (en) |
DK (1) | DK165505C (en) |
ES (1) | ES534695A0 (en) |
FI (1) | FI76808C (en) |
FR (1) | FR2549837B1 (en) |
GB (2) | GB8320521D0 (en) |
IE (1) | IE57726B1 (en) |
IL (1) | IL72536A (en) |
NL (1) | NL8402372A (en) |
NO (1) | NO167292C (en) |
NZ (1) | NZ209046A (en) |
PT (1) | PT78985B (en) |
SE (1) | SE463263B (en) |
ZA (1) | ZA845830B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8400024D0 (en) * | 1984-01-03 | 1984-02-08 | Glaxo Group Ltd | Cephalosporin antibiotics |
GB8524001D0 (en) * | 1985-09-30 | 1985-11-06 | Glaxo Group Ltd | Pharmaceutical composition |
US5063224A (en) * | 1990-07-09 | 1991-11-05 | Eli Lilly And Company | R-cefuroxime axetil |
IT1277426B1 (en) * | 1995-08-03 | 1997-11-10 | Acs Dobfar Spa | BIOAVAILABLE CRYSTALLINE FORM OF CEFUROXIMA AXETIL |
CN1111537C (en) * | 1997-05-15 | 2003-06-18 | 第一制糖株式会社 | The preparation method of highly pure crystalline form of cefuroxime axetil |
KR100228264B1 (en) * | 1997-08-02 | 1999-11-01 | 김선진 | The synthetic method of crystalline cefuroxime axetil |
CA2209868C (en) * | 1997-08-15 | 2001-08-14 | Bernard Charles Sherman | Pharmaceutical compositions comprising cefuroxime axetil |
IN186539B (en) * | 1997-09-29 | 2001-09-29 | Ranbaxy Lab Ltd | |
ATE212638T1 (en) * | 1998-02-20 | 2002-02-15 | Fako Ilaclari A S | METHOD FOR PRODUCING SOLUBLE CRYSTALLINE CEFUROXIM AXETIL |
IN190849B (en) | 2000-07-17 | 2003-08-23 | Ranbaxy Lab Ltd | |
AT411996B (en) | 2000-09-11 | 2004-08-26 | Sandoz Ag | METHOD FOR PRODUCING CEFUROXIME IN THE FORM OF ITS N-BUTYL LAMONIUM SALTS |
ITMI20011763A1 (en) * | 2001-08-10 | 2003-02-10 | Antibioticos Spa | HIGH-PURITY CEFUROXIME AXELITE PREPARATION PROCESS |
ITMI20011925A1 (en) * | 2001-09-14 | 2003-03-14 | Antibioticos Spa | METHOD APPLICABLE ON INDUSTRIAL SCALE FOR THE PREPARATION OF CEFUROXIME AXETILE CRISTALLINO |
TWI328006B (en) * | 2003-12-26 | 2010-08-01 | Nissan Chemical Ind Ltd | Crystal form of quinoline compound and process for its production |
CN100448879C (en) * | 2004-07-22 | 2009-01-07 | 北京化工大学 | Method for preparing unformed cefuroxime axetil |
DE102005019458A1 (en) | 2005-04-25 | 2006-10-26 | Grünenthal GmbH | Composition, useful in the preparation of pellets and the multi-particular-presentation form, comprises cefuroximaxetil and carrageenan of the group of lambda carrageenan, tau carrageenan and kappa carrageenan |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1571683A (en) * | 1976-02-16 | 1980-07-16 | Glaxo Operations Ltd | Ester derivatives of cefuroxime |
CA1094545A (en) * | 1976-02-16 | 1981-01-27 | Michael Gregson | Cephalosporin antibiotics |
GB1598568A (en) * | 1977-04-19 | 1981-09-23 | Glaxo Lab Ltd | Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid |
JPS577485A (en) * | 1980-06-13 | 1982-01-14 | Takeda Chem Ind Ltd | Cephalosporin |
YU44680B (en) * | 1982-07-30 | 1990-12-31 | Glaxo Lab Ltd | Process for obtaining very pure amorphous form of cephuroxim axetile |
GB8400024D0 (en) * | 1984-01-03 | 1984-02-08 | Glaxo Group Ltd | Cephalosporin antibiotics |
-
1983
- 1983-07-29 GB GB838320521A patent/GB8320521D0/en active Pending
-
1984
- 1984-07-27 IE IE1938/84A patent/IE57726B1/en not_active IP Right Cessation
- 1984-07-27 PT PT78985A patent/PT78985B/en unknown
- 1984-07-27 FI FI843011A patent/FI76808C/en not_active IP Right Cessation
- 1984-07-27 BE BE0/213398A patent/BE900241A/en not_active IP Right Cessation
- 1984-07-27 DE DE19843427828 patent/DE3427828A1/en not_active Ceased
- 1984-07-27 AT AT2444/84A patent/AT392470B/en not_active IP Right Cessation
- 1984-07-27 CA CA000459929A patent/CA1265511A/en not_active Expired - Fee Related
- 1984-07-27 NO NO843055A patent/NO167292C/en not_active IP Right Cessation
- 1984-07-27 DK DK366684A patent/DK165505C/en not_active IP Right Cessation
- 1984-07-27 JP JP59155694A patent/JPH0613526B2/en not_active Expired - Lifetime
- 1984-07-27 ES ES534695A patent/ES534695A0/en active Granted
- 1984-07-27 FR FR8412011A patent/FR2549837B1/en not_active Expired
- 1984-07-27 NL NL8402372A patent/NL8402372A/en not_active Application Discontinuation
- 1984-07-27 CH CH3672/84A patent/CH662121A5/en not_active IP Right Cessation
- 1984-07-27 SE SE8403897A patent/SE463263B/en not_active IP Right Cessation
- 1984-07-27 AU AU31256/84A patent/AU582121B2/en not_active Ceased
- 1984-07-27 ZA ZA845830A patent/ZA845830B/en unknown
- 1984-07-27 KR KR1019840004465A patent/KR910008377B1/en not_active IP Right Cessation
- 1984-07-27 GB GB08419202A patent/GB2145409B/en not_active Expired
- 1984-07-29 IL IL72536A patent/IL72536A/en not_active IP Right Cessation
- 1984-07-30 NZ NZ209046A patent/NZ209046A/en unknown
-
1989
- 1989-06-16 AU AU36601/89A patent/AU634965B2/en not_active Ceased
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Legal Events
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NAL | Patent in force |
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