AU634965B2 - Process for obtaining crystalline cefuroxime 1-acetoxyethyl ester - Google Patents

Process for obtaining crystalline cefuroxime 1-acetoxyethyl ester

Info

Publication number
AU634965B2
AU634965B2 AU36601/89A AU3660189A AU634965B2 AU 634965 B2 AU634965 B2 AU 634965B2 AU 36601/89 A AU36601/89 A AU 36601/89A AU 3660189 A AU3660189 A AU 3660189A AU 634965 B2 AU634965 B2 AU 634965B2
Authority
AU
Australia
Prior art keywords
obtaining crystalline
acetoxyethyl ester
crystalline cefuroxime
cefuroxime
acetoxyethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU36601/89A
Other versions
AU3660189A (en
Inventor
Harold Alfred Crisp
John Francis Oughton
John Peter Turnbull
Michael Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU3660189A publication Critical patent/AU3660189A/en
Application granted granted Critical
Publication of AU634965B2 publication Critical patent/AU634965B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU36601/89A 1983-07-29 1989-06-16 Process for obtaining crystalline cefuroxime 1-acetoxyethyl ester Ceased AU634965B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8320521 1983-07-29
GB838320521A GB8320521D0 (en) 1983-07-29 1983-07-29 Chemical process

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU31256/84A Division AU582121B2 (en) 1983-07-29 1984-07-27 Improvements in or relating to cephalosporins

Publications (2)

Publication Number Publication Date
AU3660189A AU3660189A (en) 1989-10-05
AU634965B2 true AU634965B2 (en) 1993-03-11

Family

ID=10546505

Family Applications (2)

Application Number Title Priority Date Filing Date
AU31256/84A Ceased AU582121B2 (en) 1983-07-29 1984-07-27 Improvements in or relating to cephalosporins
AU36601/89A Ceased AU634965B2 (en) 1983-07-29 1989-06-16 Process for obtaining crystalline cefuroxime 1-acetoxyethyl ester

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU31256/84A Ceased AU582121B2 (en) 1983-07-29 1984-07-27 Improvements in or relating to cephalosporins

Country Status (21)

Country Link
JP (1) JPH0613526B2 (en)
KR (1) KR910008377B1 (en)
AT (1) AT392470B (en)
AU (2) AU582121B2 (en)
BE (1) BE900241A (en)
CA (1) CA1265511A (en)
CH (1) CH662121A5 (en)
DE (1) DE3427828A1 (en)
DK (1) DK165505C (en)
ES (1) ES8601869A1 (en)
FI (1) FI76808C (en)
FR (1) FR2549837B1 (en)
GB (2) GB8320521D0 (en)
IE (1) IE57726B1 (en)
IL (1) IL72536A (en)
NL (1) NL8402372A (en)
NO (1) NO167292C (en)
NZ (1) NZ209046A (en)
PT (1) PT78985B (en)
SE (1) SE463263B (en)
ZA (1) ZA845830B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
GB8524001D0 (en) * 1985-09-30 1985-11-06 Glaxo Group Ltd Pharmaceutical composition
US5063224A (en) * 1990-07-09 1991-11-05 Eli Lilly And Company R-cefuroxime axetil
IT1277426B1 (en) * 1995-08-03 1997-11-10 Acs Dobfar Spa BIOAVAILABLE CRYSTALLINE FORM OF CEFUROXIMA AXETIL
CN1111537C (en) * 1997-05-15 2003-06-18 第一制糖株式会社 The preparation method of highly pure crystalline form of cefuroxime axetil
KR100228264B1 (en) * 1997-08-02 1999-11-01 김선진 The synthetic method of crystalline cefuroxime axetil
CA2209868C (en) * 1997-08-15 2001-08-14 Bernard Charles Sherman Pharmaceutical compositions comprising cefuroxime axetil
IN186539B (en) * 1997-09-29 2001-09-29 Ranbaxy Lab Ltd
ES2171056T3 (en) * 1998-02-20 2002-08-16 Fako Ilaclari A S PROCEDURE FOR THE MANUFACTURE OF SOLUBLE CRYSTALLINE AXETIL CEFUROXIMA.
IN190849B (en) 2000-07-17 2003-08-23 Ranbaxy Lab Ltd
AT411996B (en) 2000-09-11 2004-08-26 Sandoz Ag METHOD FOR PRODUCING CEFUROXIME IN THE FORM OF ITS N-BUTYL LAMONIUM SALTS
ITMI20011763A1 (en) * 2001-08-10 2003-02-10 Antibioticos Spa HIGH-PURITY CEFUROXIME AXELITE PREPARATION PROCESS
ITMI20011925A1 (en) * 2001-09-14 2003-03-14 Antibioticos Spa METHOD APPLICABLE ON INDUSTRIAL SCALE FOR THE PREPARATION OF CEFUROXIME AXETILE CRISTALLINO
TWI328006B (en) * 2003-12-26 2010-08-01 Nissan Chemical Ind Ltd Crystal form of quinoline compound and process for its production
CN100448879C (en) * 2004-07-22 2009-01-07 北京化工大学 Method for preparing unformed cefuroxime axetil
DE102005019458A1 (en) 2005-04-25 2006-10-26 Grünenthal GmbH Composition, useful in the preparation of pellets and the multi-particular-presentation form, comprises cefuroximaxetil and carrageenan of the group of lambda carrageenan, tau carrageenan and kappa carrageenan

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2228877A (en) * 1976-02-16 1978-08-24 Glaxo Operations Uk Ltd. Cephalosporin antibiotics
AU1741783A (en) * 1982-07-30 1984-02-02 Glaxo Group Limited 1-acetoxyethyl ester of (6r, 7r)-3-carbamoyloxy-methyl-7- ((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em- carboxylic acid
AU3704684A (en) * 1984-01-03 1985-07-11 Glaxo Group Limited Cephalosporin antibiotics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1571683A (en) * 1976-02-16 1980-07-16 Glaxo Operations Ltd Ester derivatives of cefuroxime
GB1598568A (en) * 1977-04-19 1981-09-23 Glaxo Lab Ltd Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
JPS577485A (en) * 1980-06-13 1982-01-14 Takeda Chem Ind Ltd Cephalosporin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2228877A (en) * 1976-02-16 1978-08-24 Glaxo Operations Uk Ltd. Cephalosporin antibiotics
AU1741783A (en) * 1982-07-30 1984-02-02 Glaxo Group Limited 1-acetoxyethyl ester of (6r, 7r)-3-carbamoyloxy-methyl-7- ((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em- carboxylic acid
AU3704684A (en) * 1984-01-03 1985-07-11 Glaxo Group Limited Cephalosporin antibiotics

Also Published As

Publication number Publication date
DE3427828A1 (en) 1985-02-14
AU582121B2 (en) 1989-03-16
FR2549837A1 (en) 1985-02-01
SE8403897L (en) 1985-01-30
GB8419202D0 (en) 1984-08-30
FI76808B (en) 1988-08-31
IL72536A0 (en) 1984-11-30
AU3660189A (en) 1989-10-05
AT392470B (en) 1991-04-10
NL8402372A (en) 1985-02-18
KR910008377B1 (en) 1991-10-12
ATA244484A (en) 1990-09-15
FI843011A0 (en) 1984-07-27
FI76808C (en) 1988-12-12
ZA845830B (en) 1986-03-26
KR850001221A (en) 1985-03-16
CH662121A5 (en) 1987-09-15
NO167292B (en) 1991-07-15
CA1265511A (en) 1990-02-06
JPH0613526B2 (en) 1994-02-23
SE463263B (en) 1990-10-29
DK366684D0 (en) 1984-07-27
ES534695A0 (en) 1985-11-01
NZ209046A (en) 1988-02-29
PT78985A (en) 1984-08-01
JPS6075484A (en) 1985-04-27
GB2145409A (en) 1985-03-27
IE57726B1 (en) 1993-03-24
NO167292C (en) 1991-10-23
AU3125684A (en) 1985-01-31
NO843055L (en) 1985-01-30
GB2145409B (en) 1987-02-18
IL72536A (en) 1988-01-31
DK165505C (en) 1993-04-19
DK366684A (en) 1985-01-30
IE841938L (en) 1985-01-29
FR2549837B1 (en) 1986-12-26
SE8403897D0 (en) 1984-07-27
BE900241A (en) 1985-01-28
ES8601869A1 (en) 1985-11-01
PT78985B (en) 1986-10-23
FI843011A (en) 1985-01-30
GB8320521D0 (en) 1983-09-01
DK165505B (en) 1992-12-07

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired