JPS57163383A - Neplanocin a derivative - Google Patents
Neplanocin a derivativeInfo
- Publication number
- JPS57163383A JPS57163383A JP17640180A JP17640180A JPS57163383A JP S57163383 A JPS57163383 A JP S57163383A JP 17640180 A JP17640180 A JP 17640180A JP 17640180 A JP17640180 A JP 17640180A JP S57163383 A JPS57163383 A JP S57163383A
- Authority
- JP
- Japan
- Prior art keywords
- neplanocin
- benzoyl
- acetyl
- compound
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formulaI(R1 is H, benzoyl; R2 is H, benzoyl; R3, R4 are H, acetyl or incorporate to form benzylidine; R5 is H, acetyl, benzoyl; at least one of R3WR5 is not H).
EXAMPLE: 2',3',5'-O-Triacetylneplanocin A.
USE: Carcinostatic agent: it has an activity of inhibiting the growth of L5178Y cells and shows carcinostatic effect equal to or more than neplanocin A.
PREPARATION: The acetylation of neplanocin A of formula II is effected by reaction of neplanocin A with acetic anhydride, usually in the presence of a tertiary organic amine such as pyridine, N-methylmorpholine, dimethylaniline to give the objective compound of formulaIwhere R1, R2 are H; R3, R4 are acetyl.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17640180A JPS57163383A (en) | 1980-12-12 | 1980-12-12 | Neplanocin a derivative |
DE19813148363 DE3148363A1 (en) | 1980-12-12 | 1981-12-07 | NEPLANOCIN A DERIVATIVES |
FR8123093A FR2500838B1 (en) | 1980-12-12 | 1981-12-10 | NEPLANOCIN A DERIVATIVES |
GB08137634A GB2100721B (en) | 1980-12-12 | 1981-12-14 | Neplanocin a derivatives with antitumor activity |
US06/776,093 US4613666A (en) | 1980-12-12 | 1985-09-16 | Neplanocin A derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17640180A JPS57163383A (en) | 1980-12-12 | 1980-12-12 | Neplanocin a derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57163383A true JPS57163383A (en) | 1982-10-07 |
JPS6232195B2 JPS6232195B2 (en) | 1987-07-13 |
Family
ID=16013021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17640180A Granted JPS57163383A (en) | 1980-12-12 | 1980-12-12 | Neplanocin a derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57163383A (en) |
-
1980
- 1980-12-12 JP JP17640180A patent/JPS57163383A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6232195B2 (en) | 1987-07-13 |
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