JPS57163383A - Neplanocin a derivative - Google Patents

Neplanocin a derivative

Info

Publication number
JPS57163383A
JPS57163383A JP17640180A JP17640180A JPS57163383A JP S57163383 A JPS57163383 A JP S57163383A JP 17640180 A JP17640180 A JP 17640180A JP 17640180 A JP17640180 A JP 17640180A JP S57163383 A JPS57163383 A JP S57163383A
Authority
JP
Japan
Prior art keywords
neplanocin
benzoyl
acetyl
compound
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17640180A
Other languages
Japanese (ja)
Other versions
JPS6232195B2 (en
Inventor
Seishi Fukukawa
Takao Hirano
Masatoshi Tsujino
Toru Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP17640180A priority Critical patent/JPS57163383A/en
Priority to DE19813148363 priority patent/DE3148363A1/en
Priority to FR8123093A priority patent/FR2500838B1/en
Priority to GB08137634A priority patent/GB2100721B/en
Publication of JPS57163383A publication Critical patent/JPS57163383A/en
Priority to US06/776,093 priority patent/US4613666A/en
Publication of JPS6232195B2 publication Critical patent/JPS6232195B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formulaI(R1 is H, benzoyl; R2 is H, benzoyl; R3, R4 are H, acetyl or incorporate to form benzylidine; R5 is H, acetyl, benzoyl; at least one of R3WR5 is not H).
EXAMPLE: 2',3',5'-O-Triacetylneplanocin A.
USE: Carcinostatic agent: it has an activity of inhibiting the growth of L5178Y cells and shows carcinostatic effect equal to or more than neplanocin A.
PREPARATION: The acetylation of neplanocin A of formula II is effected by reaction of neplanocin A with acetic anhydride, usually in the presence of a tertiary organic amine such as pyridine, N-methylmorpholine, dimethylaniline to give the objective compound of formulaIwhere R1, R2 are H; R3, R4 are acetyl.
COPYRIGHT: (C)1982,JPO&Japio
JP17640180A 1980-12-12 1980-12-12 Neplanocin a derivative Granted JPS57163383A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP17640180A JPS57163383A (en) 1980-12-12 1980-12-12 Neplanocin a derivative
DE19813148363 DE3148363A1 (en) 1980-12-12 1981-12-07 NEPLANOCIN A DERIVATIVES
FR8123093A FR2500838B1 (en) 1980-12-12 1981-12-10 NEPLANOCIN A DERIVATIVES
GB08137634A GB2100721B (en) 1980-12-12 1981-12-14 Neplanocin a derivatives with antitumor activity
US06/776,093 US4613666A (en) 1980-12-12 1985-09-16 Neplanocin A derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17640180A JPS57163383A (en) 1980-12-12 1980-12-12 Neplanocin a derivative

Publications (2)

Publication Number Publication Date
JPS57163383A true JPS57163383A (en) 1982-10-07
JPS6232195B2 JPS6232195B2 (en) 1987-07-13

Family

ID=16013021

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17640180A Granted JPS57163383A (en) 1980-12-12 1980-12-12 Neplanocin a derivative

Country Status (1)

Country Link
JP (1) JPS57163383A (en)

Also Published As

Publication number Publication date
JPS6232195B2 (en) 1987-07-13

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