JPS6473A - Novel aminoacridine derivative - Google Patents

Novel aminoacridine derivative

Info

Publication number
JPS6473A
JPS6473A JP62276238A JP27623887A JPS6473A JP S6473 A JPS6473 A JP S6473A JP 62276238 A JP62276238 A JP 62276238A JP 27623887 A JP27623887 A JP 27623887A JP S6473 A JPS6473 A JP S6473A
Authority
JP
Japan
Prior art keywords
alkyl
halogen
phenyl
formula
expressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62276238A
Other languages
Japanese (ja)
Other versions
JPH0173A (en
Inventor
Hajime Kawakami
Renzo Ouchi
Masashi Kitano
Keiichi Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Priority to JP62276238A priority Critical patent/JPS6473A/en
Publication of JPH0173A publication Critical patent/JPH0173A/en
Publication of JPS6473A publication Critical patent/JPS6473A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound expressed by formula I [R3 is H, alkyl, aralkyl, etc.; (i) R5WR7 are H, halogen, alkyl, phenyl, etc.; in R1WR4, R3' and R4' any two thereof linked to C which is not adjacent is mutually linked to form methylene, ethylene, etc., and the remainder is H, alkyl, phenyl, etc.; (ii) R5 is F, I, NO2, phenyl, etc.; R6 and R7 are H, halogen, CF3, alkyl, etc.; R1WR4, R3 and R4 are H, alkyl, alkoxy, halogen, phenyl, etc.] or acid addition salt thereof.
EXAMPLE: 9-Amino-6-fluoro-1,2,3,4-tetrahydroacridine.
USE: The above-mentioned compound has excellent acetylcholine esterase inhibiting action and useful as a remedy for senile dementia.
PREPARATION: An 2-aminobenzonitrile derivative expressed by formula II (R10WR12 are H, halogen, alkyl, etc.) is reacted with a cyclohexanone derivative expressed by formula III to provide the compound expressed by formula I wherein R8 is H.
COPYRIGHT: (C)1989,JPO&Japio
JP62276238A 1986-10-31 1987-10-31 Novel aminoacridine derivative Pending JPS6473A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62276238A JPS6473A (en) 1986-10-31 1987-10-31 Novel aminoacridine derivative

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP26158086 1986-10-31
JP61-261580 1986-10-31
JP62-78483 1987-03-30
JP62276238A JPS6473A (en) 1986-10-31 1987-10-31 Novel aminoacridine derivative

Publications (2)

Publication Number Publication Date
JPH0173A JPH0173A (en) 1989-01-05
JPS6473A true JPS6473A (en) 1989-01-05

Family

ID=26545141

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62276238A Pending JPS6473A (en) 1986-10-31 1987-10-31 Novel aminoacridine derivative

Country Status (1)

Country Link
JP (1) JPS6473A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63203664A (en) * 1987-02-13 1988-08-23 ヘキスト・マリオン・ルセル・インコーポレイテツド 9-amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds
JPH01132566A (en) * 1987-10-05 1989-05-25 Pfizer Inc 4-aminopyridine derivative
JPH032166A (en) * 1989-05-31 1991-01-08 Mitsubishi Kasei Corp 9-acylamino-tetrahydroacridine derivative and dysmnesia-improving drug containing the same derivative as active ingredient
US5241345A (en) * 1990-11-17 1993-08-31 Mita Industrial Co., Ltd. Optical system-driving device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS=1989 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63203664A (en) * 1987-02-13 1988-08-23 ヘキスト・マリオン・ルセル・インコーポレイテツド 9-amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds
JPH01132566A (en) * 1987-10-05 1989-05-25 Pfizer Inc 4-aminopyridine derivative
JPH032166A (en) * 1989-05-31 1991-01-08 Mitsubishi Kasei Corp 9-acylamino-tetrahydroacridine derivative and dysmnesia-improving drug containing the same derivative as active ingredient
US5241345A (en) * 1990-11-17 1993-08-31 Mita Industrial Co., Ltd. Optical system-driving device

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