JPS57192383A - New piperidine derivative and its preparation - Google Patents
New piperidine derivative and its preparationInfo
- Publication number
- JPS57192383A JPS57192383A JP7412781A JP7412781A JPS57192383A JP S57192383 A JPS57192383 A JP S57192383A JP 7412781 A JP7412781 A JP 7412781A JP 7412781 A JP7412781 A JP 7412781A JP S57192383 A JPS57192383 A JP S57192383A
- Authority
- JP
- Japan
- Prior art keywords
- preparation
- derivative
- formulai
- methylene
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A derivative of formulaI(m, n are 0, 1, when m is 1, n is 0 and when m is 0, n is 1; R2 is hydroxyl, lower alkoxy; n' is 0 or 1W4; X is O, S, carboxyl, hydroxymethylene, methylene; R is 1W4C alkylene; R1 is H, lower alkyl; D is hydroxyl, halogen, lower alkyl; m' is 0, 1W5) and its acid adduct.
EXAMPLE: 1-(3, 4-Dimethoxybenzoylmethyl)-4-[3, 4-dihydro-2(1H)-quinazolinon-3- yl)piperidine.
USE: Hypotensor; some of derivatives have antiulcerative and blood platelet coagulation inhibing activities.
PREPARATION: The reaction of a piperizing derivative of formula II with a compound of formula III (X' is O, S, carbonyl, methylene; X is easily releasable ester residue) gives or the reaction is followed by reduction to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7412781A JPS57192383A (en) | 1981-05-19 | 1981-05-19 | New piperidine derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7412781A JPS57192383A (en) | 1981-05-19 | 1981-05-19 | New piperidine derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57192383A true JPS57192383A (en) | 1982-11-26 |
Family
ID=13538213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7412781A Pending JPS57192383A (en) | 1981-05-19 | 1981-05-19 | New piperidine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57192383A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5656642A (en) * | 1993-04-07 | 1997-08-12 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
US8445516B2 (en) | 2004-01-29 | 2013-05-21 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical composition for promoting angiogenesis |
-
1981
- 1981-05-19 JP JP7412781A patent/JPS57192383A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5656642A (en) * | 1993-04-07 | 1997-08-12 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
US5760058A (en) * | 1993-04-07 | 1998-06-02 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
US8445516B2 (en) | 2004-01-29 | 2013-05-21 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical composition for promoting angiogenesis |
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