JPS57192383A - New piperidine derivative and its preparation - Google Patents

New piperidine derivative and its preparation

Info

Publication number
JPS57192383A
JPS57192383A JP7412781A JP7412781A JPS57192383A JP S57192383 A JPS57192383 A JP S57192383A JP 7412781 A JP7412781 A JP 7412781A JP 7412781 A JP7412781 A JP 7412781A JP S57192383 A JPS57192383 A JP S57192383A
Authority
JP
Japan
Prior art keywords
preparation
derivative
formulai
methylene
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7412781A
Other languages
Japanese (ja)
Inventor
Haruki Takai
Masayuki Teranishi
Yoshihiro Nakamizo
Kazuhiro Kubo
Yutaka Kasuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP7412781A priority Critical patent/JPS57192383A/en
Publication of JPS57192383A publication Critical patent/JPS57192383A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A derivative of formulaI(m, n are 0, 1, when m is 1, n is 0 and when m is 0, n is 1; R2 is hydroxyl, lower alkoxy; n' is 0 or 1W4; X is O, S, carboxyl, hydroxymethylene, methylene; R is 1W4C alkylene; R1 is H, lower alkyl; D is hydroxyl, halogen, lower alkyl; m' is 0, 1W5) and its acid adduct.
EXAMPLE: 1-(3, 4-Dimethoxybenzoylmethyl)-4-[3, 4-dihydro-2(1H)-quinazolinon-3- yl)piperidine.
USE: Hypotensor; some of derivatives have antiulcerative and blood platelet coagulation inhibing activities.
PREPARATION: The reaction of a piperizing derivative of formula II with a compound of formula III (X' is O, S, carbonyl, methylene; X is easily releasable ester residue) gives or the reaction is followed by reduction to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP7412781A 1981-05-19 1981-05-19 New piperidine derivative and its preparation Pending JPS57192383A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7412781A JPS57192383A (en) 1981-05-19 1981-05-19 New piperidine derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7412781A JPS57192383A (en) 1981-05-19 1981-05-19 New piperidine derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS57192383A true JPS57192383A (en) 1982-11-26

Family

ID=13538213

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7412781A Pending JPS57192383A (en) 1981-05-19 1981-05-19 New piperidine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57192383A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656642A (en) * 1993-04-07 1997-08-12 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing piperidine derivative as active ingredient
US8445516B2 (en) 2004-01-29 2013-05-21 Otsuka Pharmaceutical Co., Ltd. Pharmaceutical composition for promoting angiogenesis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656642A (en) * 1993-04-07 1997-08-12 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing piperidine derivative as active ingredient
US5760058A (en) * 1993-04-07 1998-06-02 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing piperidine derivative as active ingredient
US8445516B2 (en) 2004-01-29 2013-05-21 Otsuka Pharmaceutical Co., Ltd. Pharmaceutical composition for promoting angiogenesis

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