JPS5576853A - Preparation of derivative of terephthalic acid amide - Google Patents

Preparation of derivative of terephthalic acid amide

Info

Publication number
JPS5576853A
JPS5576853A JP14969678A JP14969678A JPS5576853A JP S5576853 A JPS5576853 A JP S5576853A JP 14969678 A JP14969678 A JP 14969678A JP 14969678 A JP14969678 A JP 14969678A JP S5576853 A JPS5576853 A JP S5576853A
Authority
JP
Japan
Prior art keywords
derivative
alcohol
formula
preparation
terephthalic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14969678A
Other languages
Japanese (ja)
Other versions
JPS6125022B2 (en
Inventor
Sakae Takaku
Mutsuji Mori
Yasushi Murakami
Yoshiyuki Oosugi
Shigeyuki Kataoka
Yasuhisa Takeda
Riku Matsuno
Yoshimitsu Iida
Akiko Fujita
Akira Okazaki
Kazuo Igusa
Toshichika Ogasawara
Minoru Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP14969678A priority Critical patent/JPS5576853A/en
Priority to DK214679A priority patent/DK214679A/en
Priority to IT7968172A priority patent/IT1165210B/en
Priority to US06/044,687 priority patent/US4221814A/en
Priority to NL7904466A priority patent/NL7904466A/en
Priority to AR276872A priority patent/AR225896A1/en
Priority to HU79CU163A priority patent/HU176077B/en
Priority to CS644181A priority patent/CS226196B2/en
Priority to CA000329379A priority patent/CA1140571A/en
Priority to DE19792923298 priority patent/DE2923298A1/en
Priority to CH540379A priority patent/CH642059A5/en
Priority to GB7920005A priority patent/GB2023576B/en
Priority to ES481416A priority patent/ES481416A1/en
Priority to FR7914734A priority patent/FR2428026A1/en
Priority to SE7905025A priority patent/SE445830B/en
Priority to SU792860202A priority patent/SU1026651A3/en
Priority to ES489475A priority patent/ES489475A0/en
Publication of JPS5576853A publication Critical patent/JPS5576853A/en
Priority to AR284485A priority patent/AR225072A1/en
Publication of JPS6125022B2 publication Critical patent/JPS6125022B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To obtain the title derivative having an excellent pharmaceutical activity, extremely easily in an industrial scale, by the reaction of a derivative of benzoxazine with an alcohol.
CONSTITUTION: The title derivative of formula III is obtained by heating a derivative of benzoxazine of formula I (R is lower alkyl) and an alcohol of formula II (R' is lower alkyl) at 50W100°C for 1W50hr, using this alcohol in a large excess amount as a starting material as well as a solvent, or using an inert solvent. The presence of 1W4 times mol of a tertiary amine, e.g. triethylamine, as a reaction assistant gives better result. For example, a lower aliphatic alcohol such as methanol, can be used as the alcohol of formula III.
COPYRIGHT: (C)1980,JPO&Japio
JP14969678A 1978-06-09 1978-12-05 Preparation of derivative of terephthalic acid amide Granted JPS5576853A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
JP14969678A JPS5576853A (en) 1978-12-05 1978-12-05 Preparation of derivative of terephthalic acid amide
DK214679A DK214679A (en) 1978-06-09 1979-05-23 TEREPHTHALIC ACID MONOAMIDE DERIVATIVES PROCEDURE FOR THEIR PREPARATION AND ANTIALLERGIC MEASURES CONTAINING THESE
IT7968172A IT1165210B (en) 1978-06-09 1979-05-31 MONO AMIDE DERIVATIVES OF TEREPHTHALIC ACID PROCEDURE FOR THEIR PREPARATION AND ANTI-ALLERGIC AGENT OBTAINED FROM THESE DERIVATIVES
US06/044,687 US4221814A (en) 1978-06-09 1979-06-01 Terephthalic acid monoamide derivatives, process for preparing the same, and an anti-allergic agent prepared from the same
NL7904466A NL7904466A (en) 1978-06-09 1979-06-07 PROCESS FOR THE PREPARATION OF AN ANTI-ALLERGIC AGENT WITH A MONOAMIDE DERIVATIVE OF TERFHTALIC ACID AS THE ACTIVE SUBSTANCE AND THE PREPARATION OF THE ACTIVE SUBSTANCE, AND THE MEDICINED PRODUCT
DE19792923298 DE2923298A1 (en) 1978-06-09 1979-06-08 TEREPHTHALIC ACID MONOAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN THE TREATMENT OF ALLERGIC DISEASES
ES481416A ES481416A1 (en) 1978-06-09 1979-06-08 Terephthalic acid monoamide derivatives, process for preparing the same, and an anti-allergic agent prepared from the same
CS644181A CS226196B2 (en) 1978-12-05 1979-06-08 Method of preparing monoamide derivative of terephtalic acid
CA000329379A CA1140571A (en) 1978-06-09 1979-06-08 Terephthalic acid monoamide derivatives, process for preparing the same, and an anti-allergic agent prepared from the same
AR276872A AR225896A1 (en) 1978-06-09 1979-06-08 PROCEDURE FOR THE PREPARATION OF A 2-MONOTEREFTALAMIDO-4-ALCANOMIDOBENZOIC ACID DERIVATIVE
CH540379A CH642059A5 (en) 1978-06-09 1979-06-08 TEREPHTHALIC ACID MONOAMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIALLERGIC PHARMACEUTICAL PREPARATION CONTAINING THEM.
GB7920005A GB2023576B (en) 1978-06-09 1979-06-08 Terephthalic acid amides
HU79CU163A HU176077B (en) 1978-06-09 1979-06-08 Process for preparing terephtalic acid monoamide derivatives
FR7914734A FR2428026A1 (en) 1978-06-09 1979-06-08 MONOAMIDE DERIVATIVES OF TEREPHTHALIC ACID, PREPARATION METHOD THEREOF AND THERAPEUTIC APPLICATION THEREOF
SE7905025A SE445830B (en) 1978-06-09 1979-06-08 TERPHALETIC ACRYMONOAMIDE DERIVATIVES, PROCEDURES FOR PREPARING IT AND ANTI-ALLERGIC AGENT
SU792860202A SU1026651A3 (en) 1978-12-05 1979-12-04 Process for preparing monoamide derivatives of therephthalic acid or their pharmaceutically acceptable salts
ES489475A ES489475A0 (en) 1978-06-09 1980-03-12 A PROCEDURE FOR THE PREPARATION OF A MONOAMIDE DERIVATIVE OF TEREFTALIC ACID
AR284485A AR225072A1 (en) 1978-06-09 1981-02-27 PROCEDURE FOR THE PREPARATION OF A 2-MONOTEREFTALAMIDO-4-ALCANAMIDOBENZOIC ACID DERIVATIVE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14969678A JPS5576853A (en) 1978-12-05 1978-12-05 Preparation of derivative of terephthalic acid amide

Publications (2)

Publication Number Publication Date
JPS5576853A true JPS5576853A (en) 1980-06-10
JPS6125022B2 JPS6125022B2 (en) 1986-06-13

Family

ID=15480808

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14969678A Granted JPS5576853A (en) 1978-06-09 1978-12-05 Preparation of derivative of terephthalic acid amide

Country Status (3)

Country Link
JP (1) JPS5576853A (en)
CS (1) CS226196B2 (en)
SU (1) SU1026651A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63162667U (en) * 1987-04-14 1988-10-24

Also Published As

Publication number Publication date
SU1026651A3 (en) 1983-06-30
JPS6125022B2 (en) 1986-06-13
CS226196B2 (en) 1984-03-19

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