JPS5663953A - Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide - Google Patents

Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide

Info

Publication number
JPS5663953A
JPS5663953A JP14093579A JP14093579A JPS5663953A JP S5663953 A JPS5663953 A JP S5663953A JP 14093579 A JP14093579 A JP 14093579A JP 14093579 A JP14093579 A JP 14093579A JP S5663953 A JPS5663953 A JP S5663953A
Authority
JP
Japan
Prior art keywords
methoxy
ethyl
methyl
raw materials
sulfamoylbenzamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14093579A
Other languages
Japanese (ja)
Inventor
Dotaro Fujimoto
Takeshi Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Pharmaceutical Corp
Original Assignee
Fujimoto Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimoto Pharmaceutical Corp filed Critical Fujimoto Pharmaceutical Corp
Priority to JP14093579A priority Critical patent/JPS5663953A/en
Publication of JPS5663953A publication Critical patent/JPS5663953A/en
Pending legal-status Critical Current

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  • Pyrrole Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound used for tranquilizing and treating duodenal ulcer directly at about room temperature in a short time without forming by-products, by condensing raw materials benzoic acid with pyrrolidine in the presence of a specific pyrrolidinium derivative.
CONSTITUTION: 2-Methoxy-5-sulfamoylbenzoic acid is reacted with N-ethyl-2- aminomethylpyrrolidine in the presence of 1-methyl-2-chloropyridinium iodied in a solvent, e.g. acetone or pyridine, preferably in the presence of a small amount of a reaction accelerator, e.g. a tertiary amine such as triethylamine, at 10W80°C, preferably 20W40°C, to give the compound of the formula. The amount of the 1-methyl-2-chloropyridinium iodide is preferably a slight excess of both the main raw materials.
COPYRIGHT: (C)1981,JPO&Japio
JP14093579A 1979-10-30 1979-10-30 Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide Pending JPS5663953A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14093579A JPS5663953A (en) 1979-10-30 1979-10-30 Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14093579A JPS5663953A (en) 1979-10-30 1979-10-30 Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide

Publications (1)

Publication Number Publication Date
JPS5663953A true JPS5663953A (en) 1981-05-30

Family

ID=15280233

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14093579A Pending JPS5663953A (en) 1979-10-30 1979-10-30 Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide

Country Status (1)

Country Link
JP (1) JPS5663953A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100432587B1 (en) * 2001-06-02 2004-05-24 화일약품주식회사 Method of preparing levosulpiride and intermediates used therein
JP2007278623A (en) * 2006-04-07 2007-10-25 Denso Corp Exhaust heat recovery system
CN103804265A (en) * 2012-11-08 2014-05-21 江苏天士力帝益药业有限公司 Synthesis and post-processing method of sulpiride or optical isomer thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53135968A (en) * 1977-05-02 1978-11-28 Teikoku Chem Ind Corp Ltd Preparation of 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl) pyrrolidine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53135968A (en) * 1977-05-02 1978-11-28 Teikoku Chem Ind Corp Ltd Preparation of 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl) pyrrolidine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100432587B1 (en) * 2001-06-02 2004-05-24 화일약품주식회사 Method of preparing levosulpiride and intermediates used therein
JP2007278623A (en) * 2006-04-07 2007-10-25 Denso Corp Exhaust heat recovery system
CN103804265A (en) * 2012-11-08 2014-05-21 江苏天士力帝益药业有限公司 Synthesis and post-processing method of sulpiride or optical isomer thereof

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