JPS5663953A - Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide - Google Patents
Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamideInfo
- Publication number
- JPS5663953A JPS5663953A JP14093579A JP14093579A JPS5663953A JP S5663953 A JPS5663953 A JP S5663953A JP 14093579 A JP14093579 A JP 14093579A JP 14093579 A JP14093579 A JP 14093579A JP S5663953 A JPS5663953 A JP S5663953A
- Authority
- JP
- Japan
- Prior art keywords
- methoxy
- ethyl
- methyl
- raw materials
- sulfamoylbenzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrrole Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound used for tranquilizing and treating duodenal ulcer directly at about room temperature in a short time without forming by-products, by condensing raw materials benzoic acid with pyrrolidine in the presence of a specific pyrrolidinium derivative.
CONSTITUTION: 2-Methoxy-5-sulfamoylbenzoic acid is reacted with N-ethyl-2- aminomethylpyrrolidine in the presence of 1-methyl-2-chloropyridinium iodied in a solvent, e.g. acetone or pyridine, preferably in the presence of a small amount of a reaction accelerator, e.g. a tertiary amine such as triethylamine, at 10W80°C, preferably 20W40°C, to give the compound of the formula. The amount of the 1-methyl-2-chloropyridinium iodide is preferably a slight excess of both the main raw materials.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14093579A JPS5663953A (en) | 1979-10-30 | 1979-10-30 | Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14093579A JPS5663953A (en) | 1979-10-30 | 1979-10-30 | Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5663953A true JPS5663953A (en) | 1981-05-30 |
Family
ID=15280233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14093579A Pending JPS5663953A (en) | 1979-10-30 | 1979-10-30 | Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5663953A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100432587B1 (en) * | 2001-06-02 | 2004-05-24 | 화일약품주식회사 | Method of preparing levosulpiride and intermediates used therein |
JP2007278623A (en) * | 2006-04-07 | 2007-10-25 | Denso Corp | Exhaust heat recovery system |
CN103804265A (en) * | 2012-11-08 | 2014-05-21 | 江苏天士力帝益药业有限公司 | Synthesis and post-processing method of sulpiride or optical isomer thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53135968A (en) * | 1977-05-02 | 1978-11-28 | Teikoku Chem Ind Corp Ltd | Preparation of 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl) pyrrolidine |
-
1979
- 1979-10-30 JP JP14093579A patent/JPS5663953A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53135968A (en) * | 1977-05-02 | 1978-11-28 | Teikoku Chem Ind Corp Ltd | Preparation of 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl) pyrrolidine |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100432587B1 (en) * | 2001-06-02 | 2004-05-24 | 화일약품주식회사 | Method of preparing levosulpiride and intermediates used therein |
JP2007278623A (en) * | 2006-04-07 | 2007-10-25 | Denso Corp | Exhaust heat recovery system |
CN103804265A (en) * | 2012-11-08 | 2014-05-21 | 江苏天士力帝益药业有限公司 | Synthesis and post-processing method of sulpiride or optical isomer thereof |
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