ES435274A1 - Substituted benzamides - Google Patents

Substituted benzamides

Info

Publication number
ES435274A1
ES435274A1 ES435274A ES435274A ES435274A1 ES 435274 A1 ES435274 A1 ES 435274A1 ES 435274 A ES435274 A ES 435274A ES 435274 A ES435274 A ES 435274A ES 435274 A1 ES435274 A1 ES 435274A1
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
alcohol
formula
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES435274A
Other languages
Spanish (es)
Original Assignee
Ile De France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7407535A external-priority patent/FR2262966A1/en
Priority claimed from FR7503800A external-priority patent/FR2299863B1/en
Application filed by Ile De France filed Critical Ile De France
Publication of ES435274A1 publication Critical patent/ES435274A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Abstract

A process for the preparation of substituted N- (2-pyrrolidinyl alcohol) -benzamides, their pharmaceutically acceptable acid addition salts, their quaternary ammonium salts, their dextrorotatory and levorotatory isomers, substituted benzamides having the following general formula **(See formula)** wherein A represents a hydrogen atom, a C1-5 alcohol group, a C2-5 alkenyl group; X represents a hydrogen atom, a C1-5 alkoxy group, a C1-5 alcohol group, a C2-5 alkenyloxy group, a C2-5 alkenyl group; Y represents a hydrogen atom, a halogen atom, a C1-5 alcohol group, a C1-5 alkoxy group, an amino, substituted amino group, such as, for example, alkylamino, acylamino, benzylamino, alkoxycarbonylamino; Z represents a hydrogen atom, a halogen atom, a C1-5 alkoxy group, a C1-5 alkylsulfonyl group, a SO2NR1R2 group in which R1 and R2, which may be identical or different, are hydrogen or a group C1-5 lower alcohol, or together with the nitrogen atom to which they are attached, form a heterocycle possibly containing another heteroatom; W represents an alcoholic group of 1 to 4 carbon atoms, which can form a straight or branched chain, and m represents an integer equal to 1, 2 or 3, characterized by reacting a compound of the formula **(See formula)** wherein B represents a halogen atom, a hydroxyl group, or an organic moiety; and A, X, Y and Z have the aforementioned meanings, with a racemic, right-handed or left-handed amine of the formula **(See formula)** wherein W, and m have the above meanings, and R3 represents a benzyl group or a hydrogen atom, or their reactive derivatives, and eventually reduce the benzyl group. (Machine-translation by Google Translate, not legally binding)
ES435274A 1974-03-05 1975-03-04 Substituted benzamides Expired ES435274A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7407535A FR2262966A1 (en) 1974-03-05 1974-03-05 N-(2-azacycloalkyl-alkyl)-benzamide derivs. - with antiemetic, antiulcer and CNS activity
FR7503800A FR2299863B1 (en) 1975-02-07 1975-02-07 Novel substituted N- (Z-pyrrolidiny alkyl) benzamides, their derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
ES435274A1 true ES435274A1 (en) 1976-12-16

Family

ID=26218210

Family Applications (1)

Application Number Title Priority Date Filing Date
ES435274A Expired ES435274A1 (en) 1974-03-05 1975-03-04 Substituted benzamides

Country Status (27)

Country Link
JP (1) JPS6015616B2 (en)
AR (1) AR206621A1 (en)
AT (1) AT358570B (en)
BG (1) BG24666A3 (en)
CA (1) CA1047504A (en)
CH (1) CH605794A5 (en)
CS (1) CS189692B2 (en)
DD (1) DD119420A5 (en)
DE (1) DE2507989A1 (en)
DK (1) DK145377C (en)
EG (1) EG12577A (en)
ES (1) ES435274A1 (en)
FI (1) FI750620A (en)
GB (1) GB1466822A (en)
HK (1) HK14078A (en)
HU (1) HU170637B (en)
IE (1) IE40818B1 (en)
IL (1) IL46696A (en)
LU (1) LU71949A1 (en)
NL (1) NL7502608A (en)
NO (1) NO750713L (en)
OA (1) OA04966A (en)
PH (1) PH14197A (en)
PL (1) PL97091B1 (en)
RO (2) RO70647A (en)
SE (1) SE411754B (en)
SU (1) SU609464A3 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ186175A (en) * 1977-01-27 1980-03-05 Shionogi & Co Meta-sulphonamidobenzamide derivatives
SE8503054D0 (en) * 1985-06-19 1985-06-19 Astra Laekemedel Ab CATECHOLCARBOXAMIDES
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
EP0314483A1 (en) * 1987-10-29 1989-05-03 Erbamont, Inc. Preparation of benzamides
FR2699533A1 (en) * 1992-12-21 1994-06-24 Mouhtaram Mohamed N-2-piperazinyl 4-amino:benzamide derivs. having antiemetic and antipsychotic activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3078497A (en) * 1960-12-29 1963-02-26 Leeds And Mieallef Dispensing containers

Also Published As

Publication number Publication date
BG24666A3 (en) 1978-04-12
DK145377B (en) 1982-11-08
JPS50123668A (en) 1975-09-29
CA1047504A (en) 1979-01-30
NO750713L (en) 1975-09-08
IE40818L (en) 1975-09-05
JPS6015616B2 (en) 1985-04-20
DK145377C (en) 1983-04-11
AT358570B (en) 1980-09-25
HK14078A (en) 1978-03-23
LU71949A1 (en) 1976-02-04
ATA160775A (en) 1980-02-15
SE411754B (en) 1980-02-04
FI750620A (en) 1975-09-06
AR206621A1 (en) 1976-08-06
AU7874075A (en) 1976-09-09
RO72844A (en) 1981-09-24
DK86975A (en) 1975-11-03
SU609464A3 (en) 1978-05-30
DE2507989A1 (en) 1975-09-11
PH14197A (en) 1981-03-26
SE7502342L (en) 1975-09-06
CH605794A5 (en) 1978-10-13
CS189692B2 (en) 1979-04-30
PL97091B1 (en) 1978-02-28
IL46696A (en) 1978-07-31
DD119420A5 (en) 1976-04-20
HU170637B (en) 1977-07-28
SU609464A1 (en) 1978-05-30
RO70647A (en) 1980-04-15
OA04966A (en) 1980-10-31
EG12577A (en) 1979-09-30
GB1466822A (en) 1977-03-09
NL7502608A (en) 1975-09-09
IL46696A0 (en) 1975-04-25
IE40818B1 (en) 1979-08-29

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