SU609464A3 - Method of obtaining n-(2-pyrrolidinylmethyl)-benzamides or salts thereof - Google Patents
Method of obtaining n-(2-pyrrolidinylmethyl)-benzamides or salts thereofInfo
- Publication number
- SU609464A3 SU609464A3 SU2112487A SU2112487A SU609464A3 SU 609464 A3 SU609464 A3 SU 609464A3 SU 2112487 A SU2112487 A SU 2112487A SU 2112487 A SU2112487 A SU 2112487A SU 609464 A3 SU609464 A3 SU 609464A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- filtered
- washed
- water
- methoxy
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
II
Изобретение относитс к способу получени новых производных N -(2-пирролидинилметил )-бензамидов или их солей, который может найти применение в хю4ико-фармацевтической промьниленнрсти .This invention relates to a process for the preparation of new derivatives of N - (2-pyrrolidinylmethyl) -benzamides or their salts, which can be used in the chemical and pharmaceutical industry.
Известен способ получени производньк 1-замещенных N -(2-пирролидииилметил )-бензги4идов путем взаимодействи N -алкил-2-аминометилпйрролидйна с соответствующей бензойной кислотой, ее ангидридом или галогёнангидфидом в среде инертного р&створктел l .A method is known for producing 1-substituted N- (2-pyrrolidiylmethyl) -benzene4ide derivatives by reacting N-alkyl-2-aminomethylpyrrolidine with the corresponding benzoic acid, its anhydride or its halo-anhydride in an inert environment of an inert l.
С целью синтеза новых производных N -(2-пиррр идинилметил) - бензамидов или их солей, обладающих ценными фар макологнчёскифш свойствами, предлагаеетс способ их получени ,основанный на известной в органической химий реакции.In order to synthesize new N - (2-pyrrr dinilmethyl) -benzamides or their salts, which possess valuable headlights with macroscopic properties, a method is proposed for their preparation, based on the reaction known in organic chemistry.
Производные N -(2-пирролидинилметил )-бензамидов общей формулыDerivatives of N - (2-pyrrolidinylmethyl) -benzamides of the general formula
cowHdHj-k ДcowHdHj-k D
YOYO
т (,)t (,)
где А - алкил с 1-5 атомами углерода;where a is alkyl with 1-5 carbon atoms;
у. - водород или алкоксигруппа с 1-5 атомами углерода;y - hydrogen or alkoxy group with 1-5 carbon atoms;
Y - водород или ё1миногруппа; Z - водород, галоген,1 сульфамоил или алкилсульфамоил, алкил содержит 1-5 атомов углерода, или их соли, получают путем взаимодействи соединени общей формулы СОВY is hydrogen or εminogroup; Z is hydrogen, halogen, 1 sulfamoyl or alkyl sulfamoyl, alkyl contains 1-5 carbon atoms, or their salts, is prepared by reacting a compound of the general formula COB
-ОА-OA
Y (inY (in
где А, X, Y, 2 юлеют указанные значени , а В - галоген, оксигруппа, алкоксил с 1-5 атомами углерода или имидазольный остаток, с соединением общей формулыwhere A, X, Y, 2 bile the indicated values, and B - halogen, hydroxy group, alkoxy with 1-5 carbon atoms or imidazole residue, with a compound of the general formula
,,
(III)(Iii)
иand
Claims (4)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7407535A FR2262966A1 (en) | 1974-03-05 | 1974-03-05 | N-(2-azacycloalkyl-alkyl)-benzamide derivs. - with antiemetic, antiulcer and CNS activity |
FR7503800A FR2299863B1 (en) | 1975-02-07 | 1975-02-07 | Novel substituted N- (Z-pyrrolidiny alkyl) benzamides, their derivatives and process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
SU609464A1 SU609464A1 (en) | 1978-05-30 |
SU609464A3 true SU609464A3 (en) | 1978-05-30 |
Family
ID=26218210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU2112487A SU609464A3 (en) | 1974-03-05 | 1975-03-04 | Method of obtaining n-(2-pyrrolidinylmethyl)-benzamides or salts thereof |
Country Status (27)
Country | Link |
---|---|
JP (1) | JPS6015616B2 (en) |
AR (1) | AR206621A1 (en) |
AT (1) | AT358570B (en) |
BG (1) | BG24666A3 (en) |
CA (1) | CA1047504A (en) |
CH (1) | CH605794A5 (en) |
CS (1) | CS189692B2 (en) |
DD (1) | DD119420A5 (en) |
DE (1) | DE2507989A1 (en) |
DK (1) | DK145377C (en) |
EG (1) | EG12577A (en) |
ES (1) | ES435274A1 (en) |
FI (1) | FI750620A (en) |
GB (1) | GB1466822A (en) |
HK (1) | HK14078A (en) |
HU (1) | HU170637B (en) |
IE (1) | IE40818B1 (en) |
IL (1) | IL46696A (en) |
LU (1) | LU71949A1 (en) |
NL (1) | NL7502608A (en) |
NO (1) | NO750713L (en) |
OA (1) | OA04966A (en) |
PH (1) | PH14197A (en) |
PL (1) | PL97091B1 (en) |
RO (2) | RO72844A (en) |
SE (1) | SE411754B (en) |
SU (1) | SU609464A3 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ186175A (en) * | 1977-01-27 | 1980-03-05 | Shionogi & Co | Meta-sulphonamidobenzamide derivatives |
SE8503054D0 (en) * | 1985-06-19 | 1985-06-19 | Astra Laekemedel Ab | CATECHOLCARBOXAMIDES |
US4772459A (en) * | 1986-09-09 | 1988-09-20 | Erbamont, Inc. | Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein |
EP0314483A1 (en) * | 1987-10-29 | 1989-05-03 | Erbamont, Inc. | Preparation of benzamides |
FR2699533A1 (en) * | 1992-12-21 | 1994-06-24 | Mouhtaram Mohamed | N-2-piperazinyl 4-amino:benzamide derivs. having antiemetic and antipsychotic activity |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3078497A (en) * | 1960-12-29 | 1963-02-26 | Leeds And Mieallef | Dispensing containers |
-
1975
- 1975-02-24 IL IL46696A patent/IL46696A/en unknown
- 1975-02-25 DE DE19752507989 patent/DE2507989A1/en not_active Withdrawn
- 1975-02-26 GB GB809575A patent/GB1466822A/en not_active Expired
- 1975-03-03 LU LU71949A patent/LU71949A1/xx unknown
- 1975-03-03 EG EG109/75A patent/EG12577A/en active
- 1975-03-03 SE SE7502342A patent/SE411754B/en not_active IP Right Cessation
- 1975-03-03 AT AT160775A patent/AT358570B/en not_active IP Right Cessation
- 1975-03-04 OA OA55430A patent/OA04966A/en unknown
- 1975-03-04 NO NO750713A patent/NO750713L/no unknown
- 1975-03-04 BG BG029148A patent/BG24666A3/en unknown
- 1975-03-04 DK DK86975A patent/DK145377C/en active
- 1975-03-04 ES ES435274A patent/ES435274A1/en not_active Expired
- 1975-03-04 HU HUSO1137A patent/HU170637B/hu not_active IP Right Cessation
- 1975-03-04 IE IE457/75A patent/IE40818B1/en unknown
- 1975-03-04 SU SU2112487A patent/SU609464A3/en active
- 1975-03-04 CS CS751445A patent/CS189692B2/en unknown
- 1975-03-04 CA CA221,240A patent/CA1047504A/en not_active Expired
- 1975-03-04 FI FI750620A patent/FI750620A/fi not_active Application Discontinuation
- 1975-03-05 DD DD184579A patent/DD119420A5/xx unknown
- 1975-03-05 RO RO7581558A patent/RO72844A/en unknown
- 1975-03-05 NL NL7502608A patent/NL7502608A/en not_active Application Discontinuation
- 1975-03-05 PL PL1975178533A patent/PL97091B1/en unknown
- 1975-03-05 RO RO7588831A patent/RO70647A/en unknown
- 1975-03-05 JP JP50027573A patent/JPS6015616B2/en not_active Expired
- 1975-03-05 CH CH279975A patent/CH605794A5/xx not_active IP Right Cessation
- 1975-04-04 AR AR257837A patent/AR206621A1/en active
-
1977
- 1977-08-22 PH PH20152A patent/PH14197A/en unknown
-
1978
- 1978-03-16 HK HK140/78A patent/HK14078A/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE2507989A1 (en) | 1975-09-11 |
HU170637B (en) | 1977-07-28 |
PL97091B1 (en) | 1978-02-28 |
OA04966A (en) | 1980-10-31 |
RO70647A (en) | 1980-04-15 |
SE411754B (en) | 1980-02-04 |
CH605794A5 (en) | 1978-10-13 |
FI750620A (en) | 1975-09-06 |
RO72844A (en) | 1981-09-24 |
DK145377C (en) | 1983-04-11 |
CA1047504A (en) | 1979-01-30 |
ES435274A1 (en) | 1976-12-16 |
BG24666A3 (en) | 1978-04-12 |
DK86975A (en) | 1975-11-03 |
SU609464A1 (en) | 1978-05-30 |
NL7502608A (en) | 1975-09-09 |
DD119420A5 (en) | 1976-04-20 |
IE40818B1 (en) | 1979-08-29 |
AU7874075A (en) | 1976-09-09 |
HK14078A (en) | 1978-03-23 |
ATA160775A (en) | 1980-02-15 |
DK145377B (en) | 1982-11-08 |
EG12577A (en) | 1979-09-30 |
IL46696A0 (en) | 1975-04-25 |
AR206621A1 (en) | 1976-08-06 |
GB1466822A (en) | 1977-03-09 |
PH14197A (en) | 1981-03-26 |
IE40818L (en) | 1975-09-05 |
IL46696A (en) | 1978-07-31 |
NO750713L (en) | 1975-09-08 |
JPS50123668A (en) | 1975-09-29 |
JPS6015616B2 (en) | 1985-04-20 |
CS189692B2 (en) | 1979-04-30 |
SE7502342L (en) | 1975-09-08 |
LU71949A1 (en) | 1976-02-04 |
AT358570B (en) | 1980-09-25 |
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