SE7502342L - - Google Patents
Info
- Publication number
- SE7502342L SE7502342L SE7502342A SE7502342A SE7502342L SE 7502342 L SE7502342 L SE 7502342L SE 7502342 A SE7502342 A SE 7502342A SE 7502342 A SE7502342 A SE 7502342A SE 7502342 L SE7502342 L SE 7502342L
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- alkoxy
- benzamides
- feb
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Abstract
1466822 Benzamides SOC D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE DE FRANCE 26 Feb 1975 [5 March 1974 7 Feb 1975] 8095/75 Heading C2C Novel benzamides of the Formula I wherein A is H, C 1-5 alkyl or C 2-5 alkenyl; X is H, C 1-5 alkoxy, C 1-5 alkyl, C 2-5 alkenyloxy or C 2-5 alkenyl; Y is H, halogen, C 1-5 alkyl, C 1-5 alkoxy, amino, alkylamino, dialkylamino, carboxylic acylamino, phthalimido, benzylamino or alkoxycarbonylamino; Z is H, halogen, C 1-5 alkoxy, C 1-5 alkylsulphonyl or NR 1 R 2 , wherein R 1 and R 2 each are H or C 1-5 alkyl or R 1 and R 2 , together with the nitrogen atom to which they are attached, form a saturated heterocyclic ring optionally containing another heteroatom; W is C 1-4 alkylene and m is 1, 2 or 3; and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof are prepared by reacting the appropriate benzoic acids or reactive derivatives thereof with amines of the formula or reactive derivatives thereof, wherein R 3 is H or benzyl, followed if necessary by removal of R 3 when benzyl by reduction. Pharmaceutical compositions contain the above benzamides or acid addition or quaternary ammonium salts thereof together with pharmaceutically acceptable carriers or diluents. The compounds are anti-emetics, anti-ulcer agents and are capable of modifying the central nervous system.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7407535A FR2262966A1 (en) | 1974-03-05 | 1974-03-05 | N-(2-azacycloalkyl-alkyl)-benzamide derivs. - with antiemetic, antiulcer and CNS activity |
| FR7503800A FR2299863B1 (en) | 1975-02-07 | 1975-02-07 | Novel substituted N- (Z-pyrrolidiny alkyl) benzamides, their derivatives and process for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7502342L true SE7502342L (en) | 1975-09-06 |
| SE411754B SE411754B (en) | 1980-02-04 |
Family
ID=26218210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7502342A SE411754B (en) | 1974-03-05 | 1975-03-03 | PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE NEW DERIVATIVES OF N- (2-PYRROLIDINYLALKYL) -BENZAMIDE |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS6015616B2 (en) |
| AR (1) | AR206621A1 (en) |
| AT (1) | AT358570B (en) |
| BG (1) | BG24666A3 (en) |
| CA (1) | CA1047504A (en) |
| CH (1) | CH605794A5 (en) |
| CS (1) | CS189692B2 (en) |
| DD (1) | DD119420A5 (en) |
| DE (1) | DE2507989A1 (en) |
| DK (1) | DK145377C (en) |
| EG (1) | EG12577A (en) |
| ES (1) | ES435274A1 (en) |
| FI (1) | FI750620A (en) |
| GB (1) | GB1466822A (en) |
| HK (1) | HK14078A (en) |
| HU (1) | HU170637B (en) |
| IE (1) | IE40818B1 (en) |
| IL (1) | IL46696A (en) |
| LU (1) | LU71949A1 (en) |
| NL (1) | NL7502608A (en) |
| NO (1) | NO750713L (en) |
| OA (1) | OA04966A (en) |
| PH (1) | PH14197A (en) |
| PL (1) | PL97091B1 (en) |
| RO (2) | RO70647A (en) |
| SE (1) | SE411754B (en) |
| SU (1) | SU609464A3 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ186175A (en) * | 1977-01-27 | 1980-03-05 | Shionogi & Co | Meta-sulphonamidobenzamide derivatives |
| SE8503054D0 (en) * | 1985-06-19 | 1985-06-19 | Astra Laekemedel Ab | CATECHOLCARBOXAMIDES |
| US4772459A (en) * | 1986-09-09 | 1988-09-20 | Erbamont, Inc. | Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein |
| EP0314483A1 (en) * | 1987-10-29 | 1989-05-03 | Erbamont, Inc. | Preparation of benzamides |
| FR2699533A1 (en) * | 1992-12-21 | 1994-06-24 | Mouhtaram Mohamed | N-2-piperazinyl 4-amino:benzamide derivs. having antiemetic and antipsychotic activity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3078497A (en) * | 1960-12-29 | 1963-02-26 | Leeds And Mieallef | Dispensing containers |
-
1975
- 1975-02-24 IL IL46696A patent/IL46696A/en unknown
- 1975-02-25 DE DE19752507989 patent/DE2507989A1/en not_active Withdrawn
- 1975-02-26 GB GB809575A patent/GB1466822A/en not_active Expired
- 1975-03-03 EG EG109/75A patent/EG12577A/en active
- 1975-03-03 AT AT160775A patent/AT358570B/en not_active IP Right Cessation
- 1975-03-03 SE SE7502342A patent/SE411754B/en not_active IP Right Cessation
- 1975-03-03 LU LU71949A patent/LU71949A1/xx unknown
- 1975-03-04 CA CA221,240A patent/CA1047504A/en not_active Expired
- 1975-03-04 NO NO750713A patent/NO750713L/no unknown
- 1975-03-04 OA OA55430A patent/OA04966A/en unknown
- 1975-03-04 HU HUSO1137A patent/HU170637B/hu not_active IP Right Cessation
- 1975-03-04 SU SU2112487A patent/SU609464A3/en active
- 1975-03-04 CS CS751445A patent/CS189692B2/en unknown
- 1975-03-04 ES ES435274A patent/ES435274A1/en not_active Expired
- 1975-03-04 BG BG7500029148A patent/BG24666A3/en unknown
- 1975-03-04 DK DK86975A patent/DK145377C/en active
- 1975-03-04 FI FI750620A patent/FI750620A/fi not_active Application Discontinuation
- 1975-03-04 IE IE457/75A patent/IE40818B1/en unknown
- 1975-03-05 RO RO7588831A patent/RO70647A/en unknown
- 1975-03-05 PL PL1975178533A patent/PL97091B1/en unknown
- 1975-03-05 DD DD184579A patent/DD119420A5/xx unknown
- 1975-03-05 NL NL7502608A patent/NL7502608A/en not_active Application Discontinuation
- 1975-03-05 JP JP50027573A patent/JPS6015616B2/en not_active Expired
- 1975-03-05 RO RO7581558A patent/RO72844A/en unknown
- 1975-03-05 CH CH279975A patent/CH605794A5/xx not_active IP Right Cessation
- 1975-04-04 AR AR257837A patent/AR206621A1/en active
-
1977
- 1977-08-22 PH PH20152A patent/PH14197A/en unknown
-
1978
- 1978-03-16 HK HK140/78A patent/HK14078A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BG24666A3 (en) | 1978-04-12 |
| DK145377B (en) | 1982-11-08 |
| JPS50123668A (en) | 1975-09-29 |
| CA1047504A (en) | 1979-01-30 |
| NO750713L (en) | 1975-09-08 |
| IE40818L (en) | 1975-09-05 |
| JPS6015616B2 (en) | 1985-04-20 |
| DK145377C (en) | 1983-04-11 |
| AT358570B (en) | 1980-09-25 |
| HK14078A (en) | 1978-03-23 |
| LU71949A1 (en) | 1976-02-04 |
| ATA160775A (en) | 1980-02-15 |
| SE411754B (en) | 1980-02-04 |
| FI750620A (en) | 1975-09-06 |
| AR206621A1 (en) | 1976-08-06 |
| AU7874075A (en) | 1976-09-09 |
| RO72844A (en) | 1981-09-24 |
| DK86975A (en) | 1975-11-03 |
| ES435274A1 (en) | 1976-12-16 |
| SU609464A3 (en) | 1978-05-30 |
| DE2507989A1 (en) | 1975-09-11 |
| PH14197A (en) | 1981-03-26 |
| CH605794A5 (en) | 1978-10-13 |
| CS189692B2 (en) | 1979-04-30 |
| PL97091B1 (en) | 1978-02-28 |
| IL46696A (en) | 1978-07-31 |
| DD119420A5 (en) | 1976-04-20 |
| HU170637B (en) | 1977-07-28 |
| SU609464A1 (en) | 1978-05-30 |
| RO70647A (en) | 1980-04-15 |
| OA04966A (en) | 1980-10-31 |
| EG12577A (en) | 1979-09-30 |
| GB1466822A (en) | 1977-03-09 |
| NL7502608A (en) | 1975-09-09 |
| IL46696A0 (en) | 1975-04-25 |
| IE40818B1 (en) | 1979-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7502342-4 Effective date: 19931008 Format of ref document f/p: F |